Nesiritide
Natrecor (nesiritide) is a protein pharmaceutical. Nesiritide was first approved as Natrecor on 2001-08-10. It is used to treat paroxysmal dyspnea in the USA. It is known to target atrial natriuretic peptide receptor 1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| paroxysmal dyspnea | — | D004418 | I50.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2325 | Injection, nesiritide, 0.1 mg |
Clinical
Clinical Trials
445 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | 9 | 22 | 17 | 27 | 113 | 181 |
| Hypertension | D006973 | EFO_0000537 | I10 | 4 | 3 | — | 12 | 21 | 38 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | 1 | 1 | 1 | 20 | 24 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | 1 | 2 | 4 | 3 | 16 | 24 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | 2 | 2 | 14 | 19 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | 7 | 10 | 17 |
| Coronary artery disease | D003324 | — | I25.1 | — | 2 | 2 | 2 | 11 | 16 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 2 | 1 | 2 | 10 | 15 |
| Dyspnea | D004417 | — | R06.0 | — | 1 | 1 | 2 | 11 | 15 |
| Renal insufficiency | D051437 | — | N19 | 3 | 5 | 1 | 1 | 7 | 15 |
Show 43 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute kidney injury | D058186 | — | N17 | 1 | 2 | 1 | — | 7 | 10 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 1 | — | 8 | 9 |
| Duchenne muscular dystrophy | D020388 | EFO_0000429 | — | — | 1 | 1 | — | 3 | 4 |
| Muscular dystrophies | D009136 | EFO_0000757 | G71.0 | — | 1 | 1 | — | 3 | 4 |
| Cardiopulmonary bypass | D002315 | — | — | 1 | 2 | 1 | — | 1 | 4 |
| Obstructive lung diseases | D008173 | — | — | — | 1 | 1 | — | 2 | 4 |
| Death | D003643 | PATO_0001422 | — | — | — | 1 | — | 3 | 4 |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | 1 | 1 | — | 1 | 3 |
| Aneurysm | D000783 | — | I72.9 | — | — | 1 | — | 2 | 3 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | — | — | 1 | — | 2 | 3 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 1 | 1 | — | — | 14 | 16 |
| Infarction | D007238 | EFO_0009463 | — | 1 | 1 | — | — | 10 | 12 |
| Congenital heart defects | D006330 | — | Q24.9 | 1 | 2 | — | — | 7 | 9 |
| Systolic murmurs | D054160 | — | R01.1 | 1 | 2 | — | — | 2 | 4 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | — | — | 2 | 3 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | 1 | — | — | 2 | 3 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 1 | 2 | — | — | 1 | 3 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | 1 | — | — | 2 | 3 |
| Asymptomatic diseases | D058070 | — | — | 1 | 1 | — | — | — | 1 |
| Heart transplantation | D016027 | EFO_0010673 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | 1 | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | — | 1 |
| Hyperinsulinism | D006946 | — | E16.1 | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Hypophosphatemia | D017674 | HP_0002148 | — | 1 | — | — | — | — | 1 |
| Cardiac resynchronization therapy | D058406 | — | — | 1 | — | — | — | — | 1 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiotoxicity | D066126 | EFO_1001482 | — | — | — | — | — | 12 | 12 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 11 | 11 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 10 | 10 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | — | 10 | 10 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 8 | 8 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 8 | 8 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 8 | 8 |
| Toxemia | D014115 | — | — | — | — | — | — | 8 | 8 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 7 | 7 |
| Emergencies | D004630 | — | — | — | — | — | — | 6 | 6 |
Show 202 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nesiritide |
| INN | nesiritide |
| Description | Natriuretic peptides B [Precursor] |
| Classification | Protein |
| Drug class | peptides: atrial natriuretic type substances |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201668 |
| ChEBI ID | — |
| PubChem CID | 16134381 |
| DrugBank | DB04899 |
| UNII ID | P7WI8UL647 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NPR1
NPR1
Organism
Homo sapiens
Gene name
NPR1
Gene synonyms
ANPRA
NCBI Gene ID
Protein name
atrial natriuretic peptide receptor 1
Protein synonyms
ANP-A, ANPR-A, Atrial natriuretic peptide receptor type A, atrionatriuretic peptide receptor A, GC-A, Guanylate cyclase A, natriuretic peptide A type receptor, natriuretic peptide receptor A, natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), NPR-A, testicular tissue protein Li 20
Uniprot ID
Mouse ortholog
Npr1 (18160)
atrial natriuretic peptide receptor 1 (P18293)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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362 adverse events reported
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