Nesiritide
Natrecor (nesiritide) is a protein pharmaceutical. Nesiritide was first approved as Natrecor on 2001-08-10. It is used to treat paroxysmal dyspnea in the USA. It is known to target atrial natriuretic peptide receptor 1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| paroxysmal dyspnea | — | D004418 | I50.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2325 | Injection, nesiritide, 0.1 mg |
Clinical
Clinical Trials
457 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | 2 | 8 | 9 | 5 | 1 | 23 |
| Renal insufficiency | D051437 | — | N19 | 1 | 4 | 6 | 1 | — | 11 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | 1 | 1 | 6 | 1 | — | 8 |
| Dyspnea | D004417 | — | R06.0 | — | — | 2 | 3 | — | 5 |
| Pulmonary edema | D011654 | EFO_1001134 | J81 | — | — | — | 1 | — | 1 |
| Aneurysm | D000783 | — | I72.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Paroxysmal dyspnea | D004418 | — | I50.1 | — | — | 3 | — | — | 3 |
| Cardiopulmonary bypass | D002315 | — | — | — | 1 | 1 | — | — | 2 |
| Coronary disease | D003327 | — | — | — | 1 | 1 | — | — | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | 1 | — | — | 2 |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | 1 | 1 | — | — | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | — | 1 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | — | 1 | — | — | 1 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | 1 | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart transplantation | D016027 | EFO_0010673 | — | — | 1 | — | — | — | 1 |
| Acute kidney injury | D058186 | — | N17 | 1 | 1 | — | — | — | 1 |
| Left ventricular dysfunction | D018487 | — | — | 1 | 1 | — | — | — | 1 |
| Diastolic heart failure | D054144 | EFO_1000899 | I50.30 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Dilated cardiomyopathy | D002311 | EFO_0000407 | I42.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nesiritide |
| INN | nesiritide |
| Description | Natriuretic peptides B [Precursor] |
| Classification | Protein |
| Drug class | peptides: atrial natriuretic type substances |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201668 |
| ChEBI ID | — |
| PubChem CID | 16134381 |
| DrugBank | DB04899 |
| UNII ID | P7WI8UL647 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NPR1
NPR1
Organism
Homo sapiens
Gene name
NPR1
Gene synonyms
ANPRA
NCBI Gene ID
Protein name
atrial natriuretic peptide receptor 1
Protein synonyms
ANP-A, ANPR-A, Atrial natriuretic peptide receptor type A, atrionatriuretic peptide receptor A, GC-A, Guanylate cyclase A, natriuretic peptide A type receptor, natriuretic peptide receptor A, natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), NPR-A, testicular tissue protein Li 20
Uniprot ID
Mouse ortholog
Npr1 (18160)
atrial natriuretic peptide receptor 1 (P18293)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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363 adverse events reported
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