Nesiritide
Natrecor (nesiritide) is a protein pharmaceutical. Nesiritide was first approved as Natrecor on 2001-08-10. It is used to treat paroxysmal dyspnea in the USA. It is known to target atrial natriuretic peptide receptor 1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| paroxysmal dyspnea | — | D004418 | I50.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2325 | Injection, nesiritide, 0.1 mg |
Clinical
Clinical Trials
263 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | 8 | 19 | 13 | 20 | 51 | 105 |
| Hypertension | D006973 | EFO_0000537 | I10 | 4 | 2 | — | 9 | 8 | 21 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | 1 | 2 | 4 | 3 | 9 | 17 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | 1 | 1 | 10 | 13 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | 2 | 1 | 8 | 12 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 3 | 5 | 1 | 1 | 4 | 12 |
| Dyspnea | D004417 | HP_0002094 | R06.0 | — | 1 | 1 | 2 | 6 | 10 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 2 | 1 | 1 | 4 | 8 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | 5 | 3 | 8 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | — | — | 1 | 4 | 7 |
Show 27 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 1 | — | 7 | 8 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | — | 5 | 6 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | 1 | 1 | 1 | — | 3 | 5 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | 1 | 1 | — | 2 | 4 |
| Cardiopulmonary bypass | D002315 | — | — | 1 | 2 | 1 | — | 1 | 4 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | — | 1 | — | 2 | 3 |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | 1 | 1 | — | 1 | 3 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | — | 1 | 1 | — | 1 | 3 |
| Death | D003643 | PATO_0001422 | — | — | — | 1 | — | 1 | 2 |
| Heart disease risk factors | D000082742 | — | — | — | — | 1 | — | — | 1 |
Show 6 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 1 | 1 | — | — | 7 | 9 |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | 1 | 2 | — | — | 5 | 7 |
| Infarction | D007238 | EFO_0009463 | — | 1 | 1 | — | — | 4 | 6 |
| Ischemia | D007511 | EFO_0000556 | — | — | 1 | — | — | 3 | 4 |
| Syndrome | D013577 | — | — | 1 | 2 | — | — | 2 | 4 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 1 | — | — | 2 | 3 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 1 | 2 | — | — | 1 | 3 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | — | 1 | — | — | 1 | 2 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | 1 | — | — | 1 | 2 |
| Systolic murmurs | D054160 | — | R01.1 | 1 | 2 | — | — | — | 2 |
Show 3 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Insulin resistance | D007333 | HP_0000855 | — | 1 | — | — | — | — | 1 |
| Hyperinsulinism | D006946 | HP_0000842 | E16.1 | 1 | — | — | — | — | 1 |
| Cardiac resynchronization therapy | D058406 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 7 | 7 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 6 | 6 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 6 | 6 |
| Aortic valve stenosis | D001024 | HP_0001650 | — | — | — | — | — | 6 | 6 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 6 | 6 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 6 | 6 |
| Toxemia | D014115 | — | — | — | — | — | — | 6 | 6 |
| Cardiotoxicity | D066126 | EFO_1001482 | — | — | — | — | — | 5 | 5 |
| Covid-19 | D000086382 | — | — | — | — | — | — | 5 | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 4 | 4 |
Show 113 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nesiritide |
| INN | nesiritide |
| Description | Natriuretic peptides B [Precursor] |
| Classification | Protein |
| Drug class | peptides: atrial natriuretic type substances |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201668 |
| ChEBI ID | — |
| PubChem CID | 16134381 |
| DrugBank | DB04899 |
| UNII ID | P7WI8UL647 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NPR1
NPR1
Organism
Homo sapiens
Gene name
NPR1
Gene synonyms
ANPRA
NCBI Gene ID
Protein name
atrial natriuretic peptide receptor 1
Protein synonyms
ANP-A, ANPR-A, Atrial natriuretic peptide receptor type A, atrionatriuretic peptide receptor A, GC-A, Guanylate cyclase A, natriuretic peptide A type receptor, natriuretic peptide receptor A, natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), NPR-A, testicular tissue protein Li 20
Uniprot ID
Mouse ortholog
Npr1 (18160)
atrial natriuretic peptide receptor 1 (P18293)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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359 adverse events reported
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