Nerofe
Nerofe is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
67 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 5 | 8 | 1 | — | 1 | 13 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 7 | 2 | — | — | 10 |
| Triple negative breast neoplasms | D064726 | — | — | 3 | 5 | 1 | — | — | 7 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | 2 | 3 | — | — | 6 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 4 | 1 | — | — | 5 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 3 | 3 | 1 | — | — | 4 |
| Uterine cervical neoplasms | D002583 | — | — | 1 | 3 | 1 | — | — | 4 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 1 | 1 | — | 2 | 4 |
| Biliary tract neoplasms | D001661 | — | C24.9 | — | 1 | 1 | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 11 | 6 | — | — | — | 13 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 3 | 4 | — | — | — | 5 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 3 | 5 | — | — | — | 5 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 2 | 4 | — | — | — | 5 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | 2 | 4 |
| Sarcoma | D012509 | — | — | 4 | 4 | — | — | — | 4 |
| Colorectal neoplasms | D015179 | — | — | 2 | 3 | — | — | — | 3 |
| Recurrence | D012008 | — | — | 1 | 2 | — | — | 1 | 3 |
| Squamous cell carcinoma | D002294 | — | — | — | 3 | — | — | — | 3 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 1 | — | — | 2 | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | — | — | — | 1 | 2 |
| Multiple endocrine neoplasia type 2a | D018813 | — | E31.22 | 1 | — | — | — | — | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 1 | — | — | — | — | 1 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 1 | — | — | — | — | 1 |
| Pseudomyxoma peritonei | D011553 | EFO_0007456 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Hypoxia | D000860 | — | R09.02 | — | — | — | — | 1 | 1 |
| Hyperoxia | D018496 | — | — | — | — | — | — | 1 | 1 |
| B-cell lymphoma | D016393 | — | — | — | — | — | — | 1 | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | — | — | — | — | 1 | 1 |
| Lung neoplasms | D008175 | — | C34.90 | — | — | — | — | 1 | 1 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 1 | 1 |
| Interstitial lung diseases | D017563 | EFO_0004244 | J84.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nerofe |
| INN | _ |
| Description | Nerofe is a protein pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C[C@@H](NC(=O)[C@H](NC(=O)[C@@H](CO)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(C)O)C(C)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297308 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | SR717JCM7M (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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