Nevanac(nepafenac)
Ilevro, Nevanac (nepafenac) is a small molecule pharmaceutical. Nepafenac was first approved as Nevanac on 2005-08-19. It is used to treat eye pain in the USA. It has been approved in Europe to treat ophthalmologic surgical procedures and postoperative pain.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Ilevro, Nevanac
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| eye pain | HP_0200026 | D058447 | H57.1 |
Agency Specific
FDA
EMA
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HCPCS
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Clinical
Clinical Trials
54 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cataract | D002386 | HP_0000518 | H26.9 | — | 5 | 8 | 11 | 2 | 26 |
| Macular edema | D008269 | — | — | — | 4 | 1 | 7 | 1 | 13 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | 4 | 4 | 1 | 10 |
| Edema | D004487 | HP_0000969 | R60.9 | — | 2 | 1 | 5 | — | 8 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | 1 | 2 | 4 |
| Intraocular pressure | D007429 | — | — | — | — | — | 2 | — | 2 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | 1 | 1 | 2 |
| Cataract extraction | D002387 | — | — | — | — | — | 2 | — | 2 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | — | — | 1 | — | 1 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | 2 | 3 | — | — | 5 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | 2 | 2 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Miosis | D015877 | HP_0000616 | H57.03 | — | 1 | — | — | — | 1 |
| Phacoemulsification | D018918 | — | — | — | 1 | — | — | — | 1 |
| Fuchs' endothelial dystrophy | D005642 | EFO_0003946 | H18.51 | — | 1 | — | — | — | 1 |
| Bacterial conjunctivitis | D003234 | EFO_1000829 | H10.0 | — | 1 | — | — | — | 1 |
| Conjunctivitis | D003231 | HP_0000509 | H10 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 1 | 1 |
| Angle-closure glaucoma | D015812 | — | — | — | — | — | — | 1 | 1 |
| Pain management | D059408 | — | — | — | — | — | — | 1 | 1 |
| Postoperative care | D011182 | — | — | — | — | — | — | 1 | 1 |
| Papilledema | D010211 | EFO_1001074 | H35.81 | — | — | — | — | 1 | 1 |
| Central serous chorioretinopathy | D056833 | — | H35.71 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nepafenac |
| INN | nepafenac |
| Description | Nepafenac is a monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery. It has a role as a prodrug, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (acetic acid derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)Cc1cccc(C(=O)c2ccccc2)c1N |
Identifiers
| PDB | — |
| CAS-ID | 78281-72-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1021 |
| ChEBI ID | 75922 |
| PubChem CID | 151075 |
| DrugBank | DB06802 |
| UNII ID | 0J9L7J6V8C (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Nepafenac
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 938 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,125 adverse events reported
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