Nemolizumab
Nemluvio (nemolizumab) is an antibody pharmaceutical. Nemolizumab was first approved as Nemluvio on 2024-08-12. It is used to treat prurigo in the USA. The pharmaceutical is active against interleukin-31 receptor subunit alpha.
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Commercial
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Trade Name
FDA
EMA
Nemluvio
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nemluvio | Biologic Licensing Application | 2025-06-26 |
Agency Specific
FDA
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Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 5 | 4 | — | 1 | 10 |
| Dermatitis | D003872 | — | L30.9 | — | 5 | 4 | — | 1 | 10 |
| Eczema | D004485 | — | L30.9 | — | 4 | 4 | — | 1 | 9 |
| Prurigo | D011536 | — | L28.2 | — | 1 | 4 | — | 1 | 6 |
| Neurodermatitis | D009450 | — | L28.0 | — | — | 4 | — | 1 | 5 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | 1 | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | 1 | — | — | 1 |
| Pruritus | D011537 | — | L29 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | 1 | — | — | — | 1 |
| Interstitial lung diseases | D017563 | EFO_0004244 | J84.9 | — | 1 | — | — | — | 1 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | — | 1 | — | — | — | 1 |
| Limited scleroderma | D045745 | EFO_1001017 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nemolizumab |
| INN | nemolizumab |
| Description | Nemolizumab is an experimental drug for the treatment of itching in people with atopic dermatitis. It is a monoclonal antibody that blocks the interleukin-31 receptor A. Results of a Phase II clinical trial were published in March 2017.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297794 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB15252 |
| UNII ID | GN465U8B72 (ChemIDplus, GSRS) |
Target
Agency Approved
IL31RA
IL31RA
Organism
Homo sapiens
Gene name
IL31RA
Gene synonyms
CRL3, GPL
NCBI Gene ID
Protein name
interleukin-31 receptor subunit alpha
Protein synonyms
class I cytokine receptor, Cytokine receptor-like 3, GLM-R, Gp130-like monocyte receptor, Gp130-like receptor, hGLM-R, IL-31 receptor subunit alpha, IL-31R subunit alpha, soluble type I cytokine receptor CRL3, ZcytoR17
Uniprot ID
Mouse ortholog
Il31ra (218624)
interleukin-31 receptor subunit alpha (Q8R501)
Alternate
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Trends
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Safety
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2,307 adverse events reported
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