Viracept(nelfinavir)
Viracept (nelfinavir) is a small molecule pharmaceutical. Nelfinavir was first approved as Viracept on 1997-03-14. It is used to treat acquired immunodeficiency syndrome in the USA. It has been approved in Europe to treat HIV infections.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Viracept (discontinued: Viracept)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nelfinavir mesylate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VIRACEPT | Agouron Pharmaceuticals | N-020779 RX | 1997-03-14 | 1 products, RLD, RS |
| VIRACEPT | Agouron Pharmaceuticals | N-021503 RX | 2003-04-30 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| viracept | New Drug Application | 2024-03-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acquired immunodeficiency syndrome | EFO_0000765 | D000163 | B20 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
147 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 17 | 33 | 22 | 7 | 30 | 105 |
| Lipodystrophy | D008060 | HP_0009125 | E88.1 | 1 | — | — | 3 | — | 4 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | 2 | — | 3 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | 1 | 1 | 3 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | 1 | — | 1 |
| Hiv-associated lipodystrophy syndrome | D039682 | EFO_1001348 | — | — | — | — | 1 | — | 1 |
| Hepatitis c | D006526 | — | B19.2 | — | — | — | 1 | — | 1 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | — | — | 1 | — | 1 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 10 | 3 | — | 8 | 21 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 7 | 4 | — | 8 | 18 |
| Communicable diseases | D003141 | — | — | — | 1 | 1 | — | 7 | 9 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | 1 | — | — | 3 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 1 | — | 1 | 3 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 2 | — | 1 | — | — | 3 |
| Immunologic deficiency syndromes | D007153 | HP_0002721 | D84.9 | — | 1 | 1 | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | — | — | 1 |
| Aids-associated nephropathy | D016263 | EFO_0007313 | — | — | — | 1 | — | — | 1 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 5 | 1 | — | — | — | 5 |
| Sarcoma | D012509 | — | — | 2 | 4 | — | — | — | 5 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 4 | — | — | — | 4 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 2 | — | — | — | 4 |
| Plasma cell neoplasms | D054219 | — | — | 3 | 2 | — | — | — | 4 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 2 | — | — | — | 4 |
| Kaposi sarcoma | D012514 | — | C46 | 1 | 3 | — | — | — | 4 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 3 | — | — | — | 3 |
| Hiv | D006678 | — | — | — | 1 | — | — | 1 | 2 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | 1 | — | — | — | 2 |
Show 18 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 3 | — | — | — | — | 3 |
| Glioblastoma | D005909 | EFO_0000515 | — | 3 | — | — | — | — | 3 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Plasmacytoma | D010954 | — | C90.3 | 1 | — | — | — | — | 1 |
| Hiv seronegativity | D018023 | — | — | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | 1 | — | — | — | — | 1 |
| Nervous system neoplasms | D009423 | — | — | 1 | — | — | — | — | 1 |
| Cardiopulmonary bypass | D002315 | — | — | 1 | — | — | — | — | 1 |
| Lymphopenia | D008231 | HP_0001888 | D72.810 | 1 | — | — | — | — | 1 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nelfinavir |
| INN | nelfinavir |
| Description | Nelfinavir is an aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties. It has a role as a HIV protease inhibitor and an antineoplastic agent. It is a member of benzamides, a member of phenols, an aryl sulfide, a secondary alcohol, a tertiary amino compound and an organic heterobicyclic compound. It is a conjugate base of a nelfinavir(1+). |
| Classification | Small molecule |
| Drug class | antivirals: HIV protease inhibitors (saquinavir type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C |
Identifiers
| PDB | — |
| CAS-ID | 159989-64-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL584 |
| ChEBI ID | 7496 |
| PubChem CID | 64143 |
| DrugBank | DB00220 |
| UNII ID | HO3OGH5D7I (ChemIDplus, GSRS) |
Target
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Variants
No data
Financial
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Estimated US medical usage
Nelfinavir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,779 adverse events reported
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