Arranon, Atriance(nelarabine)
Arranon, Atriance, Nelarabine (nelarabine) is a small molecule pharmaceutical. Nelarabine was first approved as Arranon on 2005-10-28. It is used to treat t-cell leukemia in the USA. It has been approved in Europe to treat precursor t-cell lymphoblastic leukemia-lymphoma.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Arranon, Nelarabine
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w... | Biologic Licensing Application | 2011-03-11 |
| 3ce drawing lip pen mayhap | OTC monograph not final | 2016-10-13 |
| arranon | New Drug Application | 2025-03-31 |
| center-al - acacia longifolia pollen center-al - acer negundo pollen center-al - acer saccharum pollen center-al - agrostis gigantea center-al - al... | Biologic Licensing Application | 2009-06-12 |
| cybercy mayer /kang du qing | OTC monograph not final | 2022-12-13 |
| eton q | unapproved drug other | 2021-07-12 |
| kang du qing | OTC monograph not final | 2020-12-09 |
| may medic clean sanitizer gel | OTC monograph not final | 2020-05-27 |
| may medic premium hand sanitisergel | OTC monograph not final | 2020-03-30 |
| may medic premium hand sanitizer | OTC monograph not final | 2020-03-30 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| t-cell leukemia | — | D015458 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9261 | Injection, nelarabine, 50 mg |
Clinical
Clinical Trials
31 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | — | — | — | 1 | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nelarabine |
| INN | nelarabine |
| Description | Nelarabine is a purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G). It has a role as an antineoplastic agent, a DNA synthesis inhibitor and a prodrug. It is a purine nucleoside, a beta-D-arabinoside and a monosaccharide derivative. It is functionally related to a guanine and a 9-beta-D-arabinofuranosylguanine. |
| Classification | Small molecule |
| Drug class | antineoplastics (arabinofuranosyl derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 121032-29-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201112 |
| ChEBI ID | 63612 |
| PubChem CID | 3011155 |
| DrugBank | DB01280 |
| UNII ID | 60158CV180 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 11,791 documents
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Safety
Black-box Warning
Black-box warning for: 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w..., Arranon, Center-al - acacia longifolia pollen center-al - acer negundo pollen center-al - acer saccharum pollen center-al - agrostis gigantea center-al - al..., Nelarabine, Nelearbine, Pollens - trees, sycamore, american (eastern) platanus occidentallis animal allergens, ap cattle hair and dander animal allergens, ap dog hair and ...
Adverse Events
Top Adverse Reactions
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8,934 adverse events reported
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