Nefopam
Nefopam is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
64 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 1 | 4 | 4 | 2 | 8 | 17 |
| Local anesthesia | D000772 | — | — | — | — | — | 1 | — | 1 |
| Breast feeding | D001942 | — | — | — | — | — | 1 | — | 1 |
| Tendon injuries | D013708 | — | — | — | — | — | 1 | — | 1 |
| Agnosia | D000377 | HP_0030222 | F88 | — | — | — | 1 | — | 1 |
| Anesthesia and analgesia | D000760 | — | — | — | — | — | 1 | — | 1 |
| Renal colic | D056844 | EFO_1001412 | N23 | — | — | — | 1 | — | 1 |
| Colic | D003085 | HP_0011848 | R10.83 | — | — | — | 1 | — | 1 |
| Shivering | D012768 | — | — | — | — | — | 1 | — | 1 |
| Cholecystitis | D002764 | HP_0001082 | K81 | — | — | — | 1 | — | 1 |
Show 4 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | 3 | 4 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 1 | — | 1 | 2 |
| Hyperalgesia | D006930 | — | — | — | 1 | 1 | — | 1 | 2 |
| Cardiac surgical procedures | D006348 | — | — | — | — | 1 | — | 1 | 2 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | 1 | — | — | 1 |
| Cholecystectomy | D002763 | — | — | — | — | 1 | — | — | 1 |
| Acute pain | D059787 | — | R52 | — | — | 1 | — | — | 1 |
| Wound infection | D014946 | — | — | — | 1 | 1 | — | — | 1 |
| Laparotomy | D007813 | — | — | — | 1 | 1 | — | — | 1 |
| Dyspnea | D004417 | HP_0002094 | R06.0 | — | — | 1 | — | — | 1 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 1 | — | — | 1 | 2 |
| Burns | D002056 | — | T30.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Cicatrix | D002921 | HP_0100699 | L90.5 | 1 | — | — | — | — | 1 |
| Pain management | D059408 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | — | — | — | 2 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 2 | 2 |
| Spinal fusion | D013123 | — | — | — | — | — | — | 1 | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 1 | 1 |
| Delirium | D003693 | — | R41.0 | — | — | — | — | 1 | 1 |
| Ileostomy | D007081 | EFO_0010681 | — | — | — | — | — | 1 | 1 |
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | — | 1 | 1 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | — | — | — | — | 1 | 1 |
| Retinal neoplasms | D019572 | — | C69.2 | — | — | — | — | 1 | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 1 | 1 |
Show 29 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nefopam |
| INN | nefopam |
| Description | 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine is a member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively. It is a benzoxazocine and a tertiary amino compound. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCOC(c2ccccc2)c2ccccc2C1 |
Identifiers
| PDB | — |
| CAS-ID | 110011-82-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL465026 |
| ChEBI ID | 88318 |
| PubChem CID | 4450 |
| DrugBank | — |
| UNII ID | 4UP8060B7J (ChemIDplus, GSRS) |
Target
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Trends
PubMed Central
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Additional graphs summarizing 997 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,601 adverse events reported
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