Navitoclax
Navitoclax is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against apoptosis regulator Bcl-2 and bcl-2-like protein 1.
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Commercial
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Clinical
Clinical Trials
45 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Primary myelofibrosis | D055728 | — | D47.4 | 3 | 1 | 2 | — | 1 | 7 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 15 | 3 | — | — | — | 15 |
| Leukemia | D007938 | — | C95 | 9 | 8 | — | — | — | 13 |
| Lymphoid leukemia | D007945 | — | C91 | 8 | 9 | — | — | — | 12 |
| Lymphoma | D008223 | — | C85.9 | 6 | 5 | — | — | 1 | 10 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 7 | 5 | — | — | — | 10 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 4 | 4 | — | — | 2 | 7 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | 3 | — | — | — | 5 |
| Carcinoma | D002277 | — | C80.0 | 3 | 1 | — | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 3 | 2 | — | — | — | 3 |
| Recurrence | D012008 | — | — | 3 | 2 | — | — | — | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 3 | — | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | 3 | — | — | — | — | 3 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 2 | — | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | — | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | — | — | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
| Hepatitis c | D006526 | — | B19.2 | 1 | — | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Navitoclax |
| INN | navitoclax |
| Description | Navitoclax is a N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of 4-{4-[(4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro[biphenyl]-2-yl)methyl]piperazin-1-yl}benzoic acid with the amino group of 4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells. Currently under clinical investigation as treatment for solid tumors and hematologic malignancies. It has a role as a B-cell lymphoma 2 inhibitor, an apoptosis inducer and an antineoplastic agent. It is a member of piperazines, a member of monochlorobenzenes, a member of morpholines, an aryl sulfide, a N-sulfonylcarboxamide, a sulfone, an organofluorine compound, a secondary amino compound and a tertiary amino compound. |
| Classification | Small molecule |
| Drug class | bcl-2 (B-cell lymphoma 2) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 923564-51-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL443684 |
| ChEBI ID | — |
| PubChem CID | 24978538 |
| DrugBank | DB12340 |
| UNII ID | XKJ5VVK2WD (ChemIDplus, GSRS) |
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Safety
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174 adverse events reported
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