Naphazoline
Albalon, Nafazair, Naphazoline / Pheniramine, Naphcon, Naphcon-a, Opcon, Opcon-a, Vasocon, Vasocon-a, Visine (naphazoline) is a small molecule pharmaceutical. Naphazoline was first approved as Naphcon forte on 1982-01-01. It is used to treat hyperemia, rhinitis, and sinusitis in the USA.
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Commercial
Therapeutic Areas
Trade Name
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Combinations
Naphazoline pheniramine, Naphcon-a, Opcon-a, Visine (discontinued: Vasocon-a)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Naphazoline hydrochloride
+
Pheniramine maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NAPHCON-A | Alcon Research | N-020226 OTC | 1994-06-08 | 1 products, RLD, RS |
| OPCON-A | Bausch Health Companies | N-020065 OTC | 1994-06-08 | 1 products, RLD, RS |
| VISINE | Johnson & Johnson | N-020485 OTC | 1996-01-31 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 7 select redness relief | C200263 | 2024-12-02 |
| advanced eye relief/ redness maximum relief | C200263 | 2024-09-25 |
| ak-con | ANDA | 2011-03-30 |
| alchemy 43 rescue redness relief | C200263 | 2024-03-08 |
| careone maximum redness relief eye drops | C200263 | 2023-12-23 |
| clear eyes complete 7 symptom relief | OTC monograph final | 2010-08-15 |
| clear eyes complete 7 sympton relief | C200263 | 2024-10-25 |
| clear eyes cooling itchy eye relief | C200263 | 2024-10-25 |
| clear eyes cooling redness relief | C200263 | 2024-10-25 |
| clear eyes maximum itchy eye relief | C200263 | 2024-08-21 |
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Indications
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Agency Specific
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ATC Codes
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AA: Sympathomimetics, plain
— R01AA08: Naphazoline
— R01AB: Sympathomimetics, combinations excl. corticosteroids
— R01AB02: Naphazoline
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01G: Decongestants and antiallergics
— S01GA: Sympathomimetics used as decongestants
— S01GA01: Naphazoline
— S01GA51: Naphazoline, combinations
HCPCS
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Clinical
Clinical Trials
31 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Naphazoline |
| INN | naphazoline |
| Description | Naphazoline is a medicine used as a decongestant. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion.
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| Classification | Small molecule |
| Drug class | antihistamines/local vasoconstrictors (antazoline type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | c1ccc2c(CC3=NCCN3)cccc2c1 |
Identifiers
| PDB | — |
| CAS-ID | 835-31-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL761 |
| ChEBI ID | — |
| PubChem CID | 4436 |
| DrugBank | DB06711 |
| UNII ID | H231GF11BV (ChemIDplus, GSRS) |
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Estimated US medical usage
Naphazoline
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Antazoline
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Naphazoline
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Naphazoline
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Pheniramine
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Trends
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Additional graphs summarizing 801 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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4,165 adverse events reported
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