Nafcillin
Nafcillin, Nallpen (nafcillin) is a small molecule pharmaceutical. Nafcillin was first approved as Unipen on 1982-01-01. It is used to treat bacterial endocarditis, bacterial infections, bacterial meningitis, bacterial skin diseases, and cellulitis amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Nafcillin, Nallpen (discontinued: Nafcillin, Nallpen, Unipen)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nafcillin | New Drug Application | 2024-12-06 |
| nafcillin sodium | ANDA | 2023-11-01 |
Indications
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| S0032 | Injection, nafcillin sodium, 2 grams |
Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 4 | — | 3 | 1 | 8 |
| Communicable diseases | D003141 | — | — | — | 3 | — | 3 | 1 | 7 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | 2 | 1 | — | 5 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | 3 | 1 | 1 | — | 5 |
| Infectious arthritis | D001170 | EFO_1001351 | M00 | — | 1 | — | 1 | — | 2 |
| Bacterial skin diseases | D017192 | — | — | — | 1 | — | 1 | — | 2 |
| Infectious skin diseases | D012874 | — | — | — | — | — | 1 | — | 1 |
| Skin diseases | D012871 | — | L00-L99 | — | — | — | 1 | — | 1 |
| Prosthesis-related infections | D016459 | EFO_1001406 | — | — | — | — | 1 | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gram-positive bacterial infections | D016908 | — | — | — | 3 | — | — | — | 3 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | — | — | 1 | 2 |
| Bacterial infections | D001424 | — | A49 | — | 1 | — | — | 1 | 2 |
| Wound infection | D014946 | — | — | — | 1 | — | — | — | 1 |
| Abscess | D000038 | EFO_0003030 | — | — | 1 | — | — | — | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | — | 1 |
| Burns | D002056 | — | T30.0 | — | 1 | — | — | — | 1 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | — | — | — | 1 | 2 |
| Cerebral hemorrhage | D002543 | — | — | 1 | — | — | — | — | 1 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | 1 | — | — | — | — | 1 |
| Hydrocephalus | D006849 | HP_0000238 | G91 | 1 | — | — | — | — | 1 |
| Cerebral ventriculitis | D058565 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 1 | 1 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | — | 1 | 1 |
| Neutropenia | D009503 | — | D70 | — | — | — | — | 1 | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nafcillin |
| INN | nafcillin |
| Description | Nafcillin is a penicillin in which the substituent at position 6 of the penam ring is a (2-ethoxy-1-naphthoyl)amino group. It has a role as an antibacterial drug. It is a penicillin and a penicillin allergen. It is a conjugate acid of a nafcillin(1-). |
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOc1ccc2ccccc2c1C(=O)N[C@@H]1C(=O)N2[C@@H](C(=O)O)C(C)(C)S[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 147-52-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1443 |
| ChEBI ID | 7447 |
| PubChem CID | 8982 |
| DrugBank | DB00607 |
| UNII ID | 4CNZ27M7RV (ChemIDplus, GSRS) |
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Estimated US medical usage
Nafcillin
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Trends
PubMed Central
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Additional graphs summarizing 3,438 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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630 adverse events reported
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