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AboutPricing
Drug ReportsNabumetone
Nabumetone
Nabumetone (nabumetone) is a small molecule pharmaceutical. Nabumetone was first approved as Relafen on 1991-12-24. It is used to treat inflammation, osteoarthritis, pain, and rheumatoid arthritis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Nabumetone (discontinued: Nabumetone, Relafen)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nabumetone
Tradename
Company
Number
Date
Products
RELAFENSmithkline BeechamN-019583 DISCN1991-12-24
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
nabumetoneANDA2025-11-13
nabumetone 1000 mg nabumetone 500 mg nabumetone 750 mgANDA2025-08-06
relafenANDA2020-11-25
relafen dsANDA2024-01-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
rheumatoid arthritisEFO_0000685D001172M06.9
painEFO_0003843D010146R52
inflammationMP_0001845D007249—
osteoarthritisEFO_0002506D010003M15-M19
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AX: Other antiinflammatory and antirheumatic agents, non-steroids in atc
— M01AX01: Nabumetone
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNabumetone
INNnabumetone
Description
Nabumetone is a methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a cyclooxygenase 2 inhibitor and a prodrug. It is a methoxynaphthalene and a methyl ketone.
Classification
Small molecule
Drug classcannabinol derivatives
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Structure (InChI/SMILES or Protein Sequence)
COc1ccc2cc(CCC(C)=O)ccc2c1
Identifiers
PDB—
CAS-ID42924-53-8
RxCUI—
ChEMBL IDCHEMBL1070
ChEBI ID7443
PubChem CID4409
DrugBankDB00461
UNII IDLW0TIW155Z (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Nabumetone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,308 documents
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Safety
Black-box Warning
Black-box warning for: Nabumetone, Nabumetone 1000 mg nabumetone 500 mg nabumetone 750 mg, Relafen ds
Adverse Events
Top Adverse Reactions
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1,413 adverse events reported
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