Nabiximols
Nabiximols is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
1444 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 106 | 130 | 27 | 18 | 253 | 499 |
| Cannabis | D002188 | — | — | 60 | 37 | 6 | 7 | 132 | 231 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 17 | 15 | 5 | 5 | 60 | 95 |
| Pain | D010146 | EFO_0003843 | R52 | 24 | 25 | 23 | 1 | 7 | 75 |
| Healthy volunteers/patients | — | — | — | 50 | 3 | — | 1 | 17 | 71 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 11 | 12 | 2 | 3 | 24 | 48 |
| Psychotic disorders | D011618 | — | F20.81 | 11 | 8 | 2 | 3 | 19 | 42 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 4 | 11 | 23 | 1 | 3 | 37 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 6 | 9 | 9 | 2 | 11 | 37 |
| Sclerosis | D012598 | — | — | 2 | 8 | 25 | 1 | 2 | 35 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | — | — | 8 | 16 | 12 | — | 22 | 55 |
| Marijuana use | D000074609 | — | — | 5 | 9 | 4 | — | 40 | 55 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 6 | 15 | 6 | — | 29 | 49 |
| Neoplasms | D009369 | — | C80 | 10 | 13 | 8 | — | 16 | 41 |
| Neuralgia | D009437 | EFO_0009430 | — | 4 | 10 | 16 | — | 6 | 32 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 3 | 7 | 2 | — | 17 | 28 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 6 | 12 | 3 | — | 7 | 26 |
| Marijuana smoking | D008385 | — | — | 1 | 10 | 2 | — | 11 | 21 |
| Peripheral nervous system diseases | D010523 | — | G64 | 3 | 6 | 9 | — | 1 | 17 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 1 | 7 | 2 | — | 8 | 17 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 4 | 5 | — | — | 9 | 16 |
| Driving under the influence | D000066448 | — | — | 8 | 4 | — | — | 4 | 14 |
| Addictive behavior | D016739 | EFO_0004347 | — | — | 1 | — | — | 13 | 14 |
| Tobacco use | D064424 | — | Z72.0 | 4 | 2 | — | — | 5 | 11 |
| Pharmacokinetics | D010599 | — | — | 9 | 1 | — | — | 1 | 10 |
| Hiv | D006678 | — | O98.7 | 2 | 3 | — | — | 5 | 10 |
| Sleep | D012890 | GO_0030431 | — | 1 | 3 | — | — | 6 | 10 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 5 | — | — | 1 | 9 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 2 | 7 | — | — | 1 | 9 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 2 | — | — | 6 | 9 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adolescent behavior | D000294 | — | — | 1 | — | — | — | 11 | 12 |
| Musculoskeletal pain | D059352 | — | — | 2 | — | — | — | 4 | 6 |
| Psychomotor disorders | D011596 | — | — | 2 | — | — | — | 2 | 4 |
| Drinking behavior | D004327 | EFO_0004315 | — | 1 | — | — | — | 2 | 3 |
| Neuroimaging | D059906 | — | — | 1 | — | — | — | 2 | 3 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 2 | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | 1 | 2 |
| Appetitive behavior | D001070 | — | — | 1 | — | — | — | 1 | 2 |
| Psychological codependency | D017004 | — | — | 2 | — | — | — | — | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | 1 | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 6 | 6 |
| Adolescent development | D041923 | — | — | — | — | — | — | 5 | 5 |
| Underage drinking | D000066608 | — | — | — | — | — | — | 5 | 5 |
| Recreational drug use | D000084783 | — | — | — | — | — | — | 4 | 4 |
| Cognition | D003071 | EFO_0003925 | — | — | — | — | — | 4 | 4 |
| Risk reduction behavior | D040242 | — | — | — | — | — | — | 3 | 3 |
| Personality disorders | D010554 | — | F60.6 | — | — | — | — | 3 | 3 |
| X-linked genetic diseases | D040181 | — | — | — | — | — | — | 2 | 2 |
| Intractable pain | D010148 | — | — | — | — | — | — | 2 | 2 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nabiximols |
| INN | _ |
| Description | Nabiximols (USAN, trade name Sativex) is a specific Cannabis extract that was approved in 2010 as a botanical drug in the United Kingdom. Nabiximols is sold as a mouth spray intended to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms of multiple sclerosis; it was developed by the UK company GW Pharmaceuticals. In 2019, it was proposed that following application of the spray, nabiximols is washed away from the oral mucosa by the saliva flow and ingested into the stomach, with subsequent absorption from the gastro-intestinal tract. Nabiximols is a combination drug standardized in composition, formulation, and dose. Its principal active components are the cannabinoids: tetrahydrocannabinol (THC) and cannabidiol (CBD). Each spray delivers a dose of 2.7 mg THC and 2.5 mg CBD.
|
| Classification | Small molecule |
| Drug class | cannabinol derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O.CCCCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 56575-23-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3833333 |
| ChEBI ID | — |
| PubChem CID | 44148067 |
| DrugBank | — |
| UNII ID | K4H93P747O (ChemIDplus, GSRS) |
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Safety
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202 adverse events reported
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