NEPICASTAT
Nepicastat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target dopamine beta-hydroxylase.
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Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 2 | — | — | — | 2 |
| Traumatic stress disorders | D040921 | — | — | — | 2 | — | — | — | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NEPICASTAT |
| INN | nepicastat |
| Description | Nepicastat is a member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has a role as an EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor. It is a member of tetralins, an organofluorine compound, a primary amino compound and a member of 1,3-dihydroimidazole-2-thiones. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: dopamine b-hydrolase (DBH) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCc1c[nH]c(=S)n1[C@H]1CCc2c(F)cc(F)cc2C1 |
Identifiers
| PDB | — |
| CAS-ID | 173997-05-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1188395 |
| ChEBI ID | — |
| PubChem CID | 9796181 |
| DrugBank | DB12979 |
| UNII ID | VPG12K4540 (ChemIDplus, GSRS) |
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Safety
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0 adverse events reported
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