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Drug ReportsMupirocin
Mupirocin
Centany, Mupirocin (mupirocin) is a small molecule pharmaceutical. Mupirocin was first approved as Bactroban on 1987-12-31. It is used to treat bacterial infections and impetigo in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Centany, Mupirocin (discontinued: Bactroban, Mupirocin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mupirocin
Tradename
Company
Number
Date
Products
CENTANYPadagisN-050788 RX2002-12-04
1 products
Show 1 discontinued
Mupirocin calcium
Tradename
Company
Number
Date
Products
BACTROBANGSKN-050703 DISCN1995-09-18
1 products, RLD
BACTROBANGSKN-050746 DISCN1997-12-11
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
bactrobanNew Drug Application2012-10-24
centany2007-02-13
dermacinrx clorhexacinunapproved drug other2024-12-13
dermawerx surgical plus pakANDA2015-12-09
levocetirizine dihydrochloride 2% / mupirocin 2% / triamcinolone acetonide 0.025%unapproved drug other2019-05-14
lidocaine 2% / mupirocin 2%unapproved drug other2019-05-14
metronidazole 1% / mupirocin 2% /unapproved drug other2019-05-14
metronidazole 1% / mupirocin 2%unapproved drug other2019-05-14
mupirocinANDA2025-03-25
nusurgepak surgical prep/carepakANDA2020-06-22
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial infections—D001424A49
impetigoEFO_1000714D007169L01
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06A: Antibiotics for topical use
— D06AX: Other antibiotics for topical use in atc
— D06AX09: Mupirocin
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AX: Other nasal preparations in atc
— R01AX06: Mupirocin
HCPCS
No data
Clinical
Clinical Trials
100 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544————213
Communicable diseasesD003141—————213
Staphylococcal infectionsD013203—A49.01———213
Hiv infectionsD015658EFO_0000764B20———1—1
Acquired immunodeficiency syndromeD000163EFO_0000765B20———1—1
Staphylococcus aureusD013211NCBITaxon_1280————1—1
Cross infectionD003428—————1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CellulitisD002481EFO_0003035L03.90————22
Wound healingD014945GO_0042060—————11
Bacterial infectionsD001424—A49————11
Infectious skin diseasesD012874——————11
Bacterial skin diseasesD017192——————11
ImpetigoD007169EFO_1000714L01————11
Community-acquired infectionsD017714——————11
AbscessD000038EFO_0003030—————11
FolliculitisD005499——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMupirocin
INNmupirocin
Description
Mupirocin is an alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections. It has a role as a bacterial metabolite, an antibacterial drug and a protein synthesis inhibitor. It is a monocarboxylic acid, a member of oxanes, an epoxide, a secondary alcohol, a triol and an alpha,beta-unsaturated carboxylic ester. It is a conjugate acid of a mupirocin(1-).
Classification
Small molecule
Drug classt-RNA synthetase inhibitors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C/C(=C\C(=O)OCCCCCCCCC(=O)O)C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O
Identifiers
PDB—
CAS-ID12650-69-0
RxCUI—
ChEMBL IDCHEMBL719
ChEBI ID7025
PubChem CID446596
DrugBankDB00410
UNII IDD0GX863OA5 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Mupirocin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,454 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,096 adverse events reported
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