Moxonidine
Moxonidine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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FDA approval date
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Study first post date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nucynta | New Drug Application | 2025-12-30 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02A: Antiadrenergic agents, centrally acting
— C02AC: Imidazoline receptor agonists
— C02AC05: Moxonidine
— C02L: Antihypertensives and diuretics in combination
— C02LC: Imidazoline receptor agonists in combination with diuretics
— C02LC05: Moxonidine and diuretics
HCPCS
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Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | 1 | 5 | 4 | 11 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | 4 | — | 5 |
| Abdominal obesity | D056128 | — | — | — | — | — | 2 | — | 2 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | 2 | — | 2 |
| Syndrome | D013577 | — | — | — | — | — | 2 | — | 2 |
| Depression | D003863 | — | F33.9 | — | — | — | 1 | — | 1 |
| Overweight | D050177 | — | E66.3 | — | — | — | 1 | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | 1 | — | 1 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | — | — | — | 1 | — | 1 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
| Vascular surgical procedures | D014656 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 2 | — | — | — | — | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Left ventricular hypertrophy | D017379 | EFO_0003896 | — | — | — | — | — | 1 | 1 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | — | — | — | 1 | 1 |
| Microvascular angina | D017566 | — | — | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Metabolic bone diseases | D001851 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Moxonidine |
| INN | moxonidine |
| Description | Moxonidine is an organohalogen compound and a member of pyrimidines. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1nc(C)nc(Cl)c1NC1=NCCN1 |
Identifiers
| PDB | — |
| CAS-ID | 75438-57-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19236 |
| ChEBI ID | 7009 |
| PubChem CID | 4810 |
| DrugBank | — |
| UNII ID | CC6X0L40GW (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Nucynta – Assertio Therapeutics
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Nucynta – Assertio Therapeutics
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Nucynta – Collegium Pharmaceutical
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Tabular view
Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 1,408 documents
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Safety
Black-box Warning
Black-box warning for: Nucynta
Adverse Events
Top Adverse Reactions
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28,692 adverse events reported
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