Moxifloxacin
Moxifloxacin, Vigamox (moxifloxacin) is a small molecule pharmaceutical. Moxifloxacin was first approved as Avelox on 1999-12-10. It is used to treat bacterial infections, bacterial pneumonia, bacteroides infections, bronchitis, and cystitis amongst others in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Vigamox (generic drugs available since 2014-02-18, discontinued: Avelox, Moxeza)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Moxifloxacin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MOXIFLOXACIN HYDROCHLORIDE | Fresenius Kabi | N-205572 RX | 2015-04-03 | 1 products, RLD, RS |
| VIGAMOX | Harrow | N-021598 RX | 2003-04-15 | 1 products, RLD, RS |
Show 3 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| avelox | New Drug Application | 2011-12-13 |
| avelox abc pack | New Drug Application | 2009-10-25 |
| dex-moxi | unapproved drug other | 2020-02-10 |
| dex-moxi pf | unapproved drug other | 2018-05-08 |
| dex-moxi-ketor | unapproved drug other | 2020-02-10 |
| dexmoxiketor pf | unapproved drug other | 2018-05-08 |
| ixoba m | unapproved drug other | 2021-11-03 |
| moxeza | New Drug Application | 2021-08-11 |
| moxifloxacin | ANDA | 2024-09-26 |
| moxifloxacin hydrochloride | ANDA | 2024-09-18 |
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01M: Quinolone antibacterials
— J01MA: Fluoroquinolone antibacterials, systemic
— J01MA14: Moxifloxacin
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AE: Fluoroquinolone antiinfectives, ophthalmologic
— S01AE07: Moxifloxacin
Clinical
Clinical Trials
644 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 175 | 1 | — | 4 | 2 | 182 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 7 | 28 | 21 | 6 | 9 | 62 |
| Infections | D007239 | EFO_0000544 | — | 6 | 2 | 14 | 6 | 6 | 34 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | 1 | 19 | 17 | 1 | 2 | 33 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 5 | 14 | 5 | 7 | 31 |
| Cataract | D002386 | HP_0000518 | H26.9 | 2 | 2 | 3 | 19 | 4 | 29 |
| Communicable diseases | D003141 | — | — | — | 2 | 13 | 6 | 1 | 22 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | — | 6 | 8 | 3 | 4 | 16 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 5 | 1 | 4 | 4 | — | 13 |
| Bacterial infections | D001424 | — | A49 | 3 | — | 2 | 5 | 2 | 12 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 8 | — | 1 | — | 2 | 11 |
| Keratitis | D007634 | HP_0000491 | H16 | — | 1 | 7 | — | 2 | 9 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 2 | 6 | — | — | 8 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 5 | — | 1 | — | — | 6 |
| Community-acquired infections | D017714 | — | — | — | 2 | 4 | — | — | 6 |
| Neoplasms | D009369 | — | C80 | 2 | 1 | 1 | — | 1 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | 3 | — | — | 5 |
| Keratoconus | D007640 | EFO_0004223 | H18.6 | 1 | 1 | 1 | — | 3 | 5 |
| Otitis media | D010033 | EFO_0004992 | H66.9 | — | 1 | 2 | — | 1 | 4 |
| Mycobacterium infections | D009164 | — | A31.9 | 1 | 1 | 3 | — | — | 4 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 13 | 1 | — | — | — | 14 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 3 | 1 | — | — | — | 4 |
| Pharmacological phenomena | D000069437 | — | — | 2 | 1 | — | — | — | 3 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | — | — | — | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 1 | — | — | — | 2 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | 1 | — | — | — | 2 |
| Cholangitis | D002761 | HP_0030151 | K83.0 | — | 1 | — | — | — | 1 |
| Amenorrhea | D000568 | — | N91.2 | — | 1 | — | — | — | 1 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | — | 1 | — | — | — | 1 |
| H1n1 subtype influenza a virus | D053118 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | 4 | — | — | — | 3 | 7 |
| Hepatitis c | D006526 | — | B19.2 | 6 | — | — | — | — | 6 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 5 | — | — | — | — | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 5 | — | — | — | — | 5 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 5 | — | — | — | — | 5 |
| Hypertension | D006973 | EFO_0000537 | I10 | 4 | — | — | — | — | 4 |
| Asthma | D001249 | EFO_0000270 | J45 | 4 | — | — | — | — | 4 |
| Therapeutic equivalency | D013810 | — | — | 4 | — | — | — | — | 4 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 4 | — | — | — | — | 4 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 3 | — | — | — | — | 3 |
Show 77 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | — | — | 4 | 4 |
| Pathologic dilatation | D004108 | — | — | — | — | — | — | 3 | 3 |
| Regeneration | D012038 | — | — | — | — | — | — | 3 | 3 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 2 | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 2 | 2 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | — | — | 2 | 2 |
| Pneumococcal pneumonia | D011018 | EFO_1001474 | J13 | — | — | — | — | 1 | 1 |
| Pneumococcal infections | D011008 | EFO_0000772 | J13 | — | — | — | — | 1 | 1 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | — | 1 | 1 |
| Aortic dissection | D000784 | — | I71.0 | — | — | — | — | 1 | 1 |
Show 24 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Moxifloxacin |
| INN | moxifloxacin |
| Description | Moxifloxacin is a quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents. It has a role as an antibacterial drug. It is a quinolinemonocarboxylic acid, a quinolone, a member of cyclopropanes, a pyrrolidinopiperidine, an aromatic ether, a quinolone antibiotic and a fluoroquinolone antibiotic. It is a conjugate base of a moxifloxacinium(1+). |
| Classification | Small molecule |
| Drug class | antibacterials (quinolone derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12 |
Identifiers
| PDB | — |
| CAS-ID | 151096-09-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL32 |
| ChEBI ID | 63611 |
| PubChem CID | 152946 |
| DrugBank | DB00218 |
| UNII ID | U188XYD42P (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Moxifloxacin
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Dexamethasone
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Moxifloxacin
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Trends
PubMed Central
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Additional graphs summarizing 23,706 documents
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Safety
Black-box Warning
Black-box warning for: Avelox, Avelox abc pack, Moxifloxacin hydrochloride, Moxifloxacin hydrochloride tablets, 400 mg, Trimipramine maleate
Adverse Events
Top Adverse Reactions
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29,390 adverse events reported
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