Motesanib
Motesanib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against vascular endothelial growth factor receptor 2. In addition, it is known to target vascular endothelial growth factor receptor 3 and vascular endothelial growth factor receptor 1.
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FDA approval date
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Commercial
No data
Clinical
Clinical Trials
44 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | 2 | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Motesanib |
| INN | motesanib |
| Description | Motesanib is a pyridinecarboxamide. |
| Classification | Small molecule |
| Drug class | angiogenesis inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 |
Identifiers
| PDB | — |
| CAS-ID | 453562-69-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL572881 |
| ChEBI ID | 51098 |
| PubChem CID | 11667893 |
| DrugBank | — |
| UNII ID | U1JK633AYI (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
FLT1
FLT1
Organism
Homo sapiens
Gene name
FLT1
Gene synonyms
FLT, FRT, VEGFR1
NCBI Gene ID
Protein name
vascular endothelial growth factor receptor 1
Protein synonyms
FLT, FLT-1, fms related tyrosine kinase 1, Fms-like tyrosine kinase 1, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor
Uniprot ID
Mouse ortholog
Flt1 (14254)
vascular endothelial growth factor receptor 1 (P35969)
Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 979 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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49 adverse events reported
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