Lunsumio(mosunetuzumab)
Lunsumio (mosunetuzumab) is an antibody pharmaceutical. Mosunetuzumab was first approved as Lunsumio on 2022-06-03. It is used to treat follicular lymphoma in the USA. It has been approved in Europe to treat follicular lymphoma. It is known to target B-lymphocyte antigen CD20.
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FDA approval date
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Study first post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Lunsumio
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| lunsumio | Biologic Licensing Application | 2024-12-04 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| follicular lymphoma | — | D008224 | C82 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
mosunetuzumab, Lunsumio, Genentech, Inc. | |||
| 2029-12-22 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 13 | 25 | 5 | — | — | 36 |
| B-cell lymphoma | D016393 | — | — | 11 | 13 | 1 | — | — | 20 |
| Follicular lymphoma | D008224 | — | C82 | 4 | 13 | 3 | — | — | 18 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 6 | 8 | 1 | — | — | 11 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | — | 5 | 1 | — | — | 6 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 6 | 6 | — | — | — | 10 |
| Lymphoid leukemia | D007945 | — | C91 | 3 | 3 | — | — | — | 5 |
| Leukemia | D007938 | — | C95 | 3 | 2 | — | — | — | 4 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 3 | — | — | — | 4 |
| Aggression | D000374 | EFO_0003015 | — | 2 | 1 | — | — | — | 3 |
| Recurrence | D012008 | — | — | — | 2 | — | — | — | 2 |
| Hodgkin disease | D006689 | — | C81 | — | 2 | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 1 | 1 | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | — | 1 |
| Reactive arthritis | D016918 | EFO_0007460 | M02.3 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | 1 | — | — | — | — | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 1 | — | — | — | — | 1 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mosunetuzumab |
| INN | mosunetuzumab |
| Description | Mosunetuzumab, sold under the brand name Lunsumio, is a monoclonal antibody used for the treatment of follicular lymphoma. It bispecifically binds CD20 and CD3 to engage T-cells. It was developed by Genentech.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1905409-39-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297788 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB15434 |
| UNII ID | LDJ89SS0YG (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
MS4A1
MS4A1
Organism
Homo sapiens
Gene name
MS4A1
Gene synonyms
CD20
NCBI Gene ID
Protein name
B-lymphocyte antigen CD20
Protein synonyms
B-lymphocyte cell-surface antigen B1, B-lymphocyte surface antigen B1, Bp35, CD20, CD20 antigen, CD20 receptor, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, membrane-spanning 4-domains, subfamily A, member 1
Uniprot ID
Mouse ortholog
Ms4a1 (12482)
B-lymphocyte antigen CD20 (P19437)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 604 documents
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Safety
Black-box Warning
Black-box warning for: Lunsumio
Adverse Events
Top Adverse Reactions
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586 adverse events reported
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