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Drug ReportsMorphine
Morphine
Duramorph, Embeda, Infumorph, Mitigo, Morphine, Ms Contin (morphine) is a small molecule pharmaceutical. Morphine was first approved as Duramorph pf on 1984-09-18. It is used to treat dyspnea and intractable pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target delta-type opioid receptor and kappa-type opioid receptor.
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Events Timeline
5D
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3M
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YTD
1Y
2Y
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FDA approval date
EMA approval date
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Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Infumorph, Mitigo, Morphine, Ms contin (discontinued: Arymo, Astramorph, Avinza, Depodur, Kadian, Morphine, Oramorph)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Morphine sulfate
Tradename
Company
Number
Date
Products
MORPHINE SULFATEFresenius KabiN-204223 RX2013-10-30
3 products, RLD, RS
DURAMORPH PFHikma PharmaceuticalsN-018565 RX1984-09-18
2 products, RLD, RS
INFUMORPHHikma PharmaceuticalsN-018565 RX1991-07-19
2 products, RLD, RS
MORPHINE SULFATEHikma PharmaceuticalsN-022195 RX2008-03-17
3 products, RLD
MORPHINE SULFATEHikma PharmaceuticalsN-022207 RX2008-03-17
2 products, RLD, RS
MORPHINE SULFATEHospiraN-202515 RX2011-11-14
5 products, RLD
MS CONTINPurdue PharmaN-019516 RX1987-05-29
5 products, RLD
Show 12 discontinued
Morphine sulfate
+
Naltrexone hydrochloride
Tradename
Company
Number
Date
Products
EMBEDAAlpharmaN-022321 DISCN2009-08-13
6 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
avinzaNew Drug Application2011-09-22
depodur2008-01-10
duramorphNew Drug Application2024-04-09
embedaNew Drug Application2010-01-22
infumorph 200 infumorph 500New Drug Application2024-04-10
kadianNew Drug Application2011-06-15
mitigoANDA2024-09-06
morphine sulfateANDA2024-12-30
morphine sulfate extended-release2007-09-27
morphine sulfate morphine sulfateNew Drug Application2024-10-15
Show 2 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dyspnea—D004417R06.0
intractable pain—D010148—
alcoholismEFO_0003829D000437F10.1
opioid-related disordersEFO_0005611D009293F11
drug overdose—D062787—
Agency Specific
FDA
EMA
Expiration
Code
MORPHINE SULFATE, MORPHINE SULFATE, HIKMA
2024-06-02NPP
Patent Expiration
Patent
Expires
Flag
FDA Information
Morphine Sulfate, Morphine Sulfate, Fresenius Kabi Usa
90727812034-03-12DP
91926082034-03-12U-43, U-55
92482292034-03-12DP
Morphine Sulfate, Arymo Er, Zyla
90444022033-07-01DPU-1556
95498992033-07-01DPU-1556
Morphine Sulfate / Naltrexone Hydrochloride, Embeda, Alpharma Pharms
86234182029-11-07U-1640
78159342027-12-12DP
76826332027-06-19U-1510
76826342027-06-19DP
81581562027-06-19U-1510
88461042027-06-19DP
88772472027-06-19DP
86854432025-07-03U-1508
86854442025-07-03DP
Morphine Sulfate, Morphabond Er, Ohemo Life
79556192028-08-12DP
103147882028-08-12DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07D: Antipropulsives
— A07DA: Antipropulsives
— A07DA52: Morphine, combinations
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AA: Natural opium alkaloid analgesics
— N02AA01: Morphine
— N02AA51: Morphine, combinations
— N02AG: Opioids in combination with antispasmodics
— N02AG01: Morphine and antispasmodics
R: Respiratory system drugs
— R05: Cough and cold preparations
— R05D: Cough suppressants, excl. combinations with expectorants
— R05DA: Opium alkaloids and derivatives, cough suppressants
— R05DA05: Opium alkaloids with morphine
HCPCS
Code
Description
J0364
Injection, apomorphine hydrochloride, 1 mg
J2270
Injection, morphine sulfate, up to 10 mg
J2274
Injection, morphine sulfate, preservative-free for epidural or intrathecal use, 10 mg
S0093
Injection, morphine sulfate, 500 mg (loading dose for infusion pump)
Clinical
Clinical Trials
1969 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80—2———2
DyspneaD004417—R06.0—2———2
Paroxysmal dyspneaD004418—I50.1—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMorphine
INN—
Description
Morphine is a morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy). It has a role as an opioid analgesic, a mu-opioid receptor agonist, a plant metabolite, an environmental contaminant, a xenobiotic, a vasodilator agent, an anaesthetic, a drug allergen and a geroprotector. It is an organic heteropentacyclic compound, a tertiary amino compound and a morphinane alkaloid. It is a conjugate base of a morphine(1+). It derives from a hydride of a morphinan.
Classification
Small molecule
Drug classOpioid
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
Identifiers
PDB—
CAS-ID57-27-2
RxCUI—
ChEMBL IDCHEMBL70
ChEBI ID17303
PubChem CID5288826
DrugBankDB00295
UNII ID—
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
4988
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Q9UN57
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (P42866)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Arymo – Zyla Life Sciences
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Estimated US medical usage
Morphine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Morphine
+
Naltrexone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 23,614 documents
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Safety
Black-box Warning
Black-box warning for: Avinza, Duramorph, Embeda, Infumorph 200 infumorph 500, Kadian, Mitigo, Morphine sulfate, Morphine sulfate morphine sulfate, Ms contin
Adverse Events
Top Adverse Reactions
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156,131 adverse events reported
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