Montelukast
Montelukast, Singulair (montelukast) is a small molecule pharmaceutical. Montelukast was first approved as Singulair on 1998-02-20. It is used to treat allergic rhinitis perennial and asthma in the USA. The pharmaceutical is active against cysteinyl leukotriene receptor 1. In addition, it is known to target uracil nucleotide/cysteinyl leukotriene receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Singulair (generic drugs available since 2012-08-03)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| allergic rhinitis perennial | EFO_1001417 | D012221 | J30.89 |
| asthma | EFO_0000270 | D001249 | J45 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
350 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | 13 | 29 | 40 | 46 | 30 | 153 |
| Allergic rhinitis | D065631 | — | J30.9 | 4 | 2 | 2 | 10 | 4 | 22 |
| Healthy volunteers/patients | — | — | — | 16 | — | — | 1 | 2 | 19 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | — | 1 | 12 | 4 | 1 | 18 |
| Allergic rhinitis perennial | D012221 | EFO_1001417 | J30.89 | — | — | 6 | 2 | — | 8 |
| Exercise-induced asthma | D001250 | — | J45.990 | 1 | — | 4 | 2 | 1 | 8 |
| Bronchiolitis obliterans | D001989 | EFO_0007183 | — | — | 4 | — | 1 | 1 | 6 |
| Cough | D003371 | HP_0012735 | R05 | — | 1 | — | 2 | 3 | 6 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | 2 | 2 | 1 | 5 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | 3 | 1 | 4 |
Show 26 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | 3 | 3 | — | 2 | 7 |
| Bronchiolitis | D001988 | HP_0011950 | — | — | 2 | 1 | — | 3 | 6 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 3 | 1 | 1 | — | — | 5 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | 2 | 1 | — | 2 | 4 |
| Status asthmaticus | D013224 | — | — | — | 3 | 2 | — | 1 | 4 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 1 | 1 | — | — | 3 |
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | 1 | — | 1 | — | 1 | 3 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 2 | 1 | — | — | 2 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | 1 | — | — | 1 |
| Dengue | D003715 | — | A90 | — | 1 | 1 | — | — | 1 |
Show 13 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bronchiolitis obliterans syndrome | D000092122 | — | D89.811 | — | 1 | — | — | 1 | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 2 | — | — | — | 2 |
| Bronchopulmonary dysplasia | D001997 | — | P27.8 | 1 | 1 | — | — | — | 2 |
| Interstitial lung diseases | D017563 | HP_0006530 | J84.89 | — | 1 | — | — | — | 1 |
| Cryptogenic organizing pneumonia | D018549 | EFO_1001300 | J84.116 | — | 1 | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | — | 1 |
| Fallopian tube neoplasms | D005185 | — | — | — | 1 | — | — | — | 1 |
| Peritoneal neoplasms | D010534 | — | — | — | 1 | — | — | — | 1 |
| Food-drug interactions | D018565 | — | — | — | 1 | — | — | — | 1 |
| Immune system diseases | D007154 | — | D89.9 | 1 | 1 | — | — | — | 1 |
Show 6 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 1 | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | — | — | — | 2 |
| Respiration disorders | D012120 | — | J00-J99 | 2 | — | — | — | — | 2 |
| Anterior cruciate ligament injuries | D000070598 | — | — | 1 | — | — | — | — | 1 |
| Neonatal sepsis | D000071074 | HP_0040187 | — | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Hepatitis c | D006526 | — | B19.2 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Eosinophilia | D004802 | HP_0001880 | D72.1 | — | — | — | — | 2 | 2 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | — | — | 2 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Nephrotic syndrome | D009404 | EFO_0004255 | N04 | — | — | — | — | 1 | 1 |
| Crest syndrome | D017675 | — | M34.1 | — | — | — | — | 1 | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 1 | 1 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | — | 1 | 1 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 1 | 1 |
| Conductive hearing loss | D006314 | HP_0000405 | H90.2 | — | — | — | — | 1 | 1 |
Show 5 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Montelukast |
| INN | montelukast |
| Description | Montelukast is a member of quinolines, a monocarboxylic acid and an aliphatic sulfide. It has a role as a leukotriene antagonist, an anti-asthmatic drug and an anti-arrhythmia drug. It is a conjugate acid of a montelukast(1-). |
| Classification | Small molecule |
| Drug class | antiasthmatics/antiallergics (not acting primarily as antihistamines): leukotriene receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 158966-92-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL787 |
| ChEBI ID | 50730 |
| PubChem CID | 5281040 |
| DrugBank | DB00471 |
| UNII ID | MHM278SD3E (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CYP2C8
CYP2C8
Organism
Homo sapiens
Gene name
CYP2C8
Gene synonyms
NCBI Gene ID
Protein name
cytochrome P450 2C8
Protein synonyms
CYPIIC8, Cytochrome P450 form 1, Cytochrome P450 IIC2, Cytochrome P450 MP-12, Cytochrome P450 MP-20, cytochrome P450, family 2, subfamily C, polypeptide 8, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8, flavoprotein-linked monooxygenase, microsomal monooxygenase, P450 form 1, S-mephenytoin 4-hydroxylase, xenobiotic monooxygenase
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Singulair – Organon
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Singulair – Merck Sharp & Dohme
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
Montelukast
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 8,394 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
28,056 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use