Moexipril - PharmaKB

Moexipril

Moexipril (moexipril) is a small molecule pharmaceutical. Moexipril was first approved as Univasc on 1995-04-19. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.

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Clinical

Drug

Target

Variants

Financial

Trends

Safety

Events Timeline

YTD

Max

Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

Start date

Primary completion date

Completion date

Results first post date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
urogenital diseases	D000091642
cardiovascular diseases	D002318
endocrine system diseases	D004700

Trade Name

FDA

EMA

Moexipril (discontinued: Moexipril, Univasc)

Combinations

Moexipril hydrochlorothiazide (discontinued: Moexipril hydrochlorothiazide, Uniretic)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Hydrochlorothiazide

Moexipril hydrochloride

Tradename	Company	Number	Date	Products
UNIRETIC	UCB	N-020729 DISCN	1997-06-27	3 products

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Moexipril hydrochloride

Tradename	Company	Number	Date	Products
UNIVASC	UCB	N-020312 DISCN	1995-04-19	2 products

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Labels

FDA

EMA

Brand Name	Status	Last Update
moexipril hydrochloride	ANDA	2025-03-10
univasc	New Drug Application	2016-02-23

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
heart failure	EFO_0003144	D006333	I50
diabetic nephropathies	EFO_0000401	D003928	—
hypertension	EFO_0000537	D006973	I10
left ventricular dysfunction	—	D018487	—
nephrotic syndrome	EFO_0004255	D009404	N04
edema	—	D004487	R60.9

Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

C: Cardiovascular system drugs

— C09: Agents acting on the renin-angiotensin system

— C09A: Ace inhibitors, plain

— C09AA: Ace inhibitors, plain

— C09AA13: Moexipril

— C09B: Ace inhibitors, combinations

— C09BA: Ace inhibitors and diuretics

— C09BA13: Moexipril and diuretics

HCPCS

No data

Clinical

Clinical Trials

10 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Hypotension	D007022	EFO_0005251	I95	—	—	—	1	1	2

Indications Phases 3

No data

Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Liver cirrhosis	D008103	EFO_0001422	K74.0	—	1	—	—	—	1
Fibrosis	D005355	—	—	—	1	—	—	—	1
Biliary liver cirrhosis	D008105	—	K74.3	—	1	—	—	—	1

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Healthy volunteers/patients	—	—	—	4	—	—	—	—	4

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Hypertension	D006973	EFO_0000537	I10	—	—	—	—	3	3
Covid-19	D000086382	—	U07.1	—	—	—	—	1	1
Obesity	D009765	EFO_0001073	E66.9	—	—	—	—	1	1

Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Moexipril
INN	moexipril
Description	Moexipril is a peptide.
Classification	Small molecule
Drug class	antihypertensives (ACE inhibitors)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1Cc2cc(OC)c(OC)cc2C[C@H]1C(=O)O

Identifiers

PDB	—
CAS-ID	103775-10-6
RxCUI	—
ChEMBL ID	CHEMBL1165
ChEBI ID	6960
PubChem CID	91270
DrugBank	DB00691
UNII ID	WT87C52TJZ (ChemIDplus, GSRS)

Target

Agency Approved

ACE

Organism

Homo sapiens

Gene name

ACE

Gene synonyms

DCP, DCP1

NCBI Gene ID

1636

Protein name

angiotensin-converting enzyme

Protein synonyms

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P

Uniprot ID

Q7M4L4

Mouse ortholog

Ace (11421)

angiotensin-converting enzyme (P09470)

Alternate

No data

Variants

No data

Financial

Revenue by drug

€

₣

No data

Estimated US medical usage

Moexipril

Hydrochlorothiazide

Total medical expenditures per year (USD, in millions)

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Number of persons purchased

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Number of purchases

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Refill frequency

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Price per prescription (USD)

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Moexipril

Total medical expenditures per year (USD, in millions)

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Number of persons purchased

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Number of purchases

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Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Additional graphs summarizing 443 documents

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Safety

Black-box Warning

Black-box warning for: Moexipril hydrochloride, Univasc

Adverse Events

Top Adverse Reactions

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101 adverse events reported

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