Modafinil
Modafinil, Provigil (modafinil) is a small molecule pharmaceutical. Modafinil was first approved as Provigil on 1998-12-24. It is used to treat attention deficit disorder with hyperactivity, fatigue, narcolepsy, and obstructive sleep apnea in the USA. It is known to target sodium-dependent dopamine transporter.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Modafinil, Provigil (discontinued: Modafinil)
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Clinical
Clinical Trials
211 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleepiness | D000077260 | — | R40.0 | — | 1 | 14 | 4 | 1 | 19 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | 7 | 1 | 1 | 9 |
| Depression | D003863 | — | F33.9 | — | 3 | 5 | 2 | — | 9 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | — | — | 7 | 1 | — | 8 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 2 | 5 | 2 | — | 8 |
| Disorders of excessive somnolence | D006970 | — | G47.1 | — | — | 4 | 2 | 1 | 7 |
| Apnea | D001049 | HP_0002104 | R06.81 | — | — | 6 | 1 | — | 7 |
| Sleep wake disorders | D012893 | — | G47 | — | — | 4 | 1 | 1 | 6 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 2 | — | 2 | 1 | 5 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | 2 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Narcolepsy | D009290 | HP_0030050 | G47.4 | — | — | 7 | — | 1 | 8 |
| Fatigue | D005221 | HP_0012378 | R53.83 | — | 4 | 2 | — | 2 | 7 |
| Circadian rhythm sleep disorders | D020178 | — | G47.2 | — | — | 4 | — | 1 | 5 |
| Parasomnias | D020447 | — | G47.5 | — | — | 4 | — | — | 4 |
| Hyperkinesis | D006948 | HP_0000752 | — | — | 1 | 2 | — | — | 3 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | 1 | 2 | — | — | 3 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | 2 | — | 1 | 3 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | 2 | — | 1 | 3 |
| Brain injuries | D001930 | — | S06.9 | — | — | 2 | — | 1 | 3 |
| Syndrome | D013577 | — | — | — | — | 2 | — | — | 2 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioma | D005910 | EFO_0000520 | — | — | 2 | — | — | — | 2 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 1 | — | — | — | 1 |
| Cognition disorders | D003072 | — | — | — | 1 | — | — | — | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | — | — | — | 1 |
| Sleep deprivation | D012892 | — | F51.12 | — | 1 | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Drug therapy | D004358 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | — | — | — | — | 1 | 1 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | — | — | — | — | 1 | 1 |
| Myeloid leukemia | D007951 | — | C92 | — | — | — | — | 1 | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 1 | 1 |
| Central nervous system neoplasms | D016543 | — | — | — | — | — | — | 1 | 1 |
| Nervous system neoplasms | D009423 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Modafinil |
| INN | modafinil |
| Description | 2-[(diphenylmethyl)sulfinyl]acetamide is a sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group. It is a sulfoxide and a monocarboxylic acid amide. |
| Classification | Small molecule |
| Drug class | CNS stimulanteugeroic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 112111-43-0 |
| RxCUI | 30125 |
| ChEMBL ID | CHEMBL1373 |
| ChEBI ID | 77585 |
| PubChem CID | 4236 |
| DrugBank | DB00745 |
| UNII ID | R3UK8X3U3D (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
SLC6A3
SLC6A3
Organism
Homo sapiens
Gene name
SLC6A3
Gene synonyms
DAT1
NCBI Gene ID
Protein name
sodium-dependent dopamine transporter
Protein synonyms
DA transporter, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, Solute carrier family 6 member 3
Uniprot ID
Mouse ortholog
Slc6a3 (13162)
sodium-dependent dopamine transporter (Q9R1I2)
Variants
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Financial
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Provigil – Cephalon
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Modafinil
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Trends
PubMed Central
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Additional graphs summarizing 6,930 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8,172 adverse events reported
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