Modafinil
Modafinil, Provigil (modafinil) is a small molecule pharmaceutical. Modafinil was first approved as Provigil on 1998-12-24. It is used to treat attention deficit disorder with hyperactivity, fatigue, narcolepsy, and obstructive sleep apnea in the USA. It is known to target sodium-dependent dopamine transporter.
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Commercial
Therapeutic Areas
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Modafinil, Provigil (discontinued: Modafinil)
Indications
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Clinical
Clinical Trials
211 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fatigue | D005221 | HP_0012378 | R53.83 | 3 | 12 | 9 | 6 | 5 | 33 |
| Sleepiness | D000077260 | — | R40.0 | 1 | 6 | 20 | 5 | 3 | 33 |
| Disorders of excessive somnolence | D006970 | — | G47.1 | — | 7 | 9 | 3 | 5 | 23 |
| Healthy volunteers/patients | — | — | — | 14 | 1 | — | 1 | 4 | 19 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | 1 | 1 | 8 | 3 | 1 | 14 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | 1 | 8 | 3 | 1 | 13 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 3 | 4 | — | 5 | 1 | 12 |
| Sleep wake disorders | D012893 | — | G47 | — | 2 | 5 | 1 | 3 | 11 |
| Apnea | D001049 | HP_0002104 | R06.81 | 1 | 1 | 6 | 3 | — | 11 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 1 | 3 | 3 | 2 | 2 | 11 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | 4 | 15 | 1 | — | 3 | 22 |
| Narcolepsy | D009290 | HP_0030050 | G47.4 | 3 | 3 | 11 | — | 4 | 21 |
| Neoplasms | D009369 | — | C80 | 1 | 4 | 3 | — | 1 | 9 |
| Brain injuries | D001930 | — | S06.9 | 2 | 2 | 2 | — | 1 | 6 |
| Parasomnias | D020447 | — | G47.5 | — | 1 | 5 | — | — | 6 |
| Syndrome | D013577 | — | — | 1 | 1 | 3 | — | — | 5 |
| Circadian rhythm sleep disorders | D020178 | — | G47.2 | — | — | 4 | — | 1 | 5 |
| Cataplexy | D002385 | HP_0002524 | — | — | 1 | 2 | — | 1 | 4 |
| Traumatic brain injuries | D000070642 | — | S06 | 1 | — | 2 | — | 1 | 4 |
| Hyperkinesis | D006948 | HP_0000752 | — | — | 1 | 2 | — | — | 3 |
Show 25 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 3 | — | — | 2 | 5 |
| Sleep deprivation | D012892 | — | F51.12 | 2 | 2 | — | — | 1 | 5 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 2 | — | — | 2 | 4 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 2 | 1 | — | — | 1 | 4 |
| Nervous system neoplasms | D009423 | — | — | — | 3 | — | — | 1 | 4 |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 1 | 3 | — | — | — | 4 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | 2 | 3 |
| Cognition disorders | D003072 | — | — | — | 2 | — | — | 1 | 3 |
| Central nervous system neoplasms | D016543 | — | — | — | 2 | — | — | 1 | 3 |
| Tachycardia | D013610 | HP_0001649 | R00.0 | 2 | 1 | — | — | — | 2 |
Show 21 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Humans | D006801 | — | — | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 1 | — | — | — | — | 1 |
| Cannabis | D002188 | — | — | 1 | — | — | — | — | 1 |
| Neurobehavioral manifestations | D019954 | EFO_0004364 | — | 1 | — | — | — | — | 1 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | — | — | — | — | 1 | 1 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | — | — | — | — | 1 | 1 |
| Myeloid leukemia | D007951 | — | C92 | — | — | — | — | 1 | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | — | 1 | 1 |
| Glucose metabolism disorders | D044882 | — | — | — | — | — | — | 1 | 1 |
| Lymphoma | D008223 | — | C85.9 | — | — | — | — | 1 | 1 |
| B-cell lymphoma | D016393 | — | — | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | — | — | — | — | — | 1 | 1 |
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Creativity | D003405 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Modafinil |
| INN | modafinil |
| Description | 2-[(diphenylmethyl)sulfinyl]acetamide is a sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group. It is a sulfoxide and a monocarboxylic acid amide. |
| Classification | Small molecule |
| Drug class | CNS stimulanteugeroic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 112111-43-0 |
| RxCUI | 30125 |
| ChEMBL ID | CHEMBL1373 |
| ChEBI ID | 77585 |
| PubChem CID | 4236 |
| DrugBank | DB00745 |
| UNII ID | R3UK8X3U3D (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
SLC6A3
SLC6A3
Organism
Homo sapiens
Gene name
SLC6A3
Gene synonyms
DAT1
NCBI Gene ID
Protein name
sodium-dependent dopamine transporter
Protein synonyms
DA transporter, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, Solute carrier family 6 member 3
Uniprot ID
Mouse ortholog
Slc6a3 (13162)
sodium-dependent dopamine transporter (Q9R1I2)
Variants
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Financial
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Provigil – Cephalon
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Estimated US medical usage
Modafinil
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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7,967 adverse events reported
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