Mitoguazone
Mitoguazone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 1 | 2 | 1 | — | 2 | 5 |
| Leukemia | D007938 | — | C95 | — | — | 1 | — | 1 | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | — | 1 | — | 1 | 2 |
| Myeloid leukemia | D007951 | — | C92 | — | — | 1 | — | 1 | 2 |
| Hodgkin disease | D006689 | — | C81 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | 1 | 2 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | — | — | 1 | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 1 | — | — | 1 | 2 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | 2 | 2 | — | — | — | 2 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | 2 | 2 | — | — | — | 2 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | 1 | — | — | — | 1 |
| Carcinoid tumor | D002276 | — | D3A.00 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sexually transmitted diseases | D012749 | — | A50-A64 | — | — | — | — | 1 | 1 |
| Gender identity | D005783 | — | — | — | — | — | — | 1 | 1 |
| Transsexualism | D014189 | — | F64.0 | — | — | — | — | 1 | 1 |
| Gender dysphoria | D000068116 | — | — | — | — | — | — | 1 | 1 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | — | — | 1 | 1 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | — | — | — | — | 1 | 1 |
| Apnea | D001049 | HP_0002104 | R06.81 | — | — | — | — | 1 | 1 |
| Health behavior | D015438 | — | — | — | — | — | — | 1 | 1 |
| Parenting | D016487 | — | — | — | — | — | — | 1 | 1 |
| Psychological distance | D012929 | — | — | — | — | — | — | 1 | 1 |
Show 6 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mitoguazone |
| INN | mitoguazone |
| Description | Mitoguazone is a hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor. It is a hydrazone and a member of guanidines. It is functionally related to a methylglyoxal and an aminoguanidine. It is a conjugate base of a mitoguazone(2+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(/C=N/NC(=N)N)=N\NC(=N)N |
Identifiers
| PDB | — |
| CAS-ID | 459-86-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL216913 |
| ChEBI ID | 43996 |
| PubChem CID | 5351154 |
| DrugBank | — |
| UNII ID | OD5Q0L447W (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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49 adverse events reported
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