Mitoguazone
Mitoguazone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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25 clinical trials
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | — | 1 | — | — | — | 1 |
| Merkel cell carcinoma | D015266 | EFO_1001471 | C4A | — | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 1 | — | — | — | 1 |
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Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mitoguazone |
| INN | mitoguazone |
| Description | Mitoguazone is a hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor. It is a hydrazone and a member of guanidines. It is functionally related to a methylglyoxal and an aminoguanidine. It is a conjugate base of a mitoguazone(2+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(/C=N/NC(=N)N)=N\NC(=N)N |
Identifiers
| PDB | — |
| CAS-ID | 459-86-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL216913 |
| ChEBI ID | 43996 |
| PubChem CID | 5351154 |
| DrugBank | — |
| UNII ID | OD5Q0L447W (ChemIDplus, GSRS) |
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50 adverse events reported
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