Mirtazapine
Mirtazapine, Remeron (mirtazapine) is a small molecule pharmaceutical. Mirtazapine was first approved as Remeron on 1996-06-14. It is used to treat depressive disorder in the USA. The pharmaceutical is active against alpha-2C adrenergic receptor, 5-hydroxytryptamine receptor 2C, alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 2A, and alpha-2A adrenergic receptor.
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FDA approval date
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Patent expiration date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Mirtazapine, Remeron, Remeron soltab (discontinued: Mirtazapine, Remeron)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| mirtazapine | ANDA | 2025-10-03 |
| remeron | New Drug Application | 2012-02-17 |
| remeron remeronsoltab | New Drug Application | 2025-08-06 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| depressive disorder | EFO_1002014 | D003866 | F32.A |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
138 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mirtazapine |
| INN | mirtazapine |
| Description | Mirtazapine is a benzazepine and a tetracyclic antidepressant. It has a role as an alpha-adrenergic antagonist, a serotonergic antagonist, a histamine antagonist, an anxiolytic drug, a H1-receptor antagonist and a oneirogen. |
| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN2c3ncccc3Cc3ccccc3C2C1 |
Identifiers
| PDB | — |
| CAS-ID | 61337-67-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL654 |
| ChEBI ID | 6950 |
| PubChem CID | 4205 |
| DrugBank | DB00370 |
| UNII ID | A051Q2099Q (ChemIDplus, GSRS) |
Target
Agency Approved
ADRA2C
ADRA2C
HTR2C
HTR2C
ADRA2B
ADRA2B
HTR2A
HTR2A
ADRA2A
ADRA2A
Organism
Homo sapiens
Gene name
ADRA2C
Gene synonyms
ADRA2L2, ADRA2RL2
NCBI Gene ID
Protein name
alpha-2C adrenergic receptor
Protein synonyms
adrenergic, alpha-2C-, receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR, alpha2-AR-C4
Uniprot ID
Mouse ortholog
Adra2c (11553)
alpha-2C adrenergic receptor (Q01337)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Remeron – Organon
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Estimated US medical usage
Mirtazapine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,845 documents
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Safety
Black-box Warning
Black-box warning for: Mirtazapine, Remeron, Remeron remeronsoltab
Adverse Events
Top Adverse Reactions
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41,562 adverse events reported
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