Milnacipran
Milnacipran, Savella (milnacipran) is a small molecule pharmaceutical. Milnacipran was first approved as Savella on 2009-01-14. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Savella (discontinued: Milnacipran)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| milnacipran hcl | ANDA | 2024-07-30 |
| savella | New Drug Application | 2025-09-10 |
| savella savella | New Drug Application | 2017-12-31 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| major depressive disorder | EFO_0003761 | D003865 | F22 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Milnacipran Hydrochloride, Savella, Abbvie | |||
| 7994220 | 2029-09-19 | U-819 | |
HCPCS
No data
Clinical
Clinical Trials
72 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | — | — | — | 1 | 1 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Milnacipran |
| INN | milnacipran |
| Description | (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide is a member of acetamides. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)C(=O)C1(c2ccccc2)CC1CN |
Identifiers
| PDB | — |
| CAS-ID | 92623-85-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL259209 |
| ChEBI ID | — |
| PubChem CID | 65833 |
| DrugBank | DB04896 |
| UNII ID | G56VK1HF36 (ChemIDplus, GSRS) |
Target
Agency Approved
SLC6A4
SLC6A4
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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€
£
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Savella – Allergan
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Savella – Warner Chilcott
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Estimated US medical usage
Milnacipran
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,457 documents
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Safety
Black-box Warning
Black-box warning for: Milnacipran hcl, Savella, Savella savella
Adverse Events
Top Adverse Reactions
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3,234 adverse events reported
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