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Drug ReportsMilnacipran
Milnacipran
Milnacipran, Savella (milnacipran) is a small molecule pharmaceutical. Milnacipran was first approved as Savella on 2009-01-14. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter.
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Savella (discontinued: Milnacipran)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Milnacipran hydrochloride
Tradename
Company
Number
Date
Products
SAVELLAAbbVieN-022256 RX2009-01-14
4 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
milnacipran hclANDA2024-07-30
savellaNew Drug Application2025-03-04
savella savellaNew Drug Application2017-12-31
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Milnacipran Hydrochloride, Savella, Abbvie
79942202029-09-19U-819
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AX: Other antidepressants in atc
— N06AX17: Milnacipran
HCPCS
No data
Clinical
Clinical Trials
72 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myofascial pain syndromesD009209EFO_1001054—————11
FibromyalgiaD005356EFO_0005687M79.1————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMilnacipran
INNmilnacipran
Description
(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide is a member of acetamides.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)C(=O)C1(c2ccccc2)CC1CN
Identifiers
PDB—
CAS-ID92623-85-3
RxCUI—
ChEMBL IDCHEMBL259209
ChEBI ID—
PubChem CID65833
DrugBankDB04896
UNII IDG56VK1HF36 (ChemIDplus, GSRS)
Target
Agency Approved
SLC6A4
SLC6A4
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Savella – Allergan
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Savella – Warner Chilcott
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Estimated US medical usage
Milnacipran
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,384 documents
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Safety
Black-box Warning
Black-box warning for: Milnacipran hcl, Savella, Savella savella
Adverse Events
Top Adverse Reactions
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3,107 adverse events reported
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