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AboutPricing
Drug ReportsMidodrine
Midodrine
Midodrine, Orvaten (midodrine) is a small molecule pharmaceutical. Midodrine was first approved as Proamatine on 1996-09-06. It is used to treat orthostatic hypotension and urinary incontinence in the USA.
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Midodrine, Orvaten (discontinued: Midodrine, Proamatine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Midodrine hydrochloride
Tradename
Company
Number
Date
Products
PROAMATINETakedaN-019815 DISCN1996-09-06
3 products, RLD
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FDA
EMA
Brand Name
Status
Last Update
midodrine hydrochlorideANDA2024-12-26
midodrine hclANDA2024-05-21
midodrine hydrochlorideANDA2025-03-06
proamatineNew Drug Application2010-05-26
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
orthostatic hypotension—D007024I95.1
urinary incontinence—D014549R32
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01C: Cardiac stimulants excl. cardiac glycosides
— C01CA: Adrenergic and dopaminergic cardiac stimulants
— C01CA17: Midodrine
HCPCS
No data
Clinical
Clinical Trials
92 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———3————3
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMidodrine
INNmidodrine
Description
Midodrine is an aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as a prodrug, an alpha-adrenergic agonist, a sympathomimetic agent and a vasoconstrictor agent. It is a secondary alcohol, an amino acid amide and an aromatic ether. It is functionally related to a glycinamide and a deglymidodrine. It is a conjugate base of a midodrine(1+).
Classification
Small molecule
Drug classsympathomimetics
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(OC)c(C(O)CNC(=O)CN)c1
Identifiers
PDB—
CAS-ID42794-76-3
RxCUI—
ChEMBL IDCHEMBL1201212
ChEBI ID6933
PubChem CID4195
DrugBankDB00211
UNII ID6YE7PBM15H (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Midodrine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,584 documents
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Safety
Black-box Warning
Black-box warning for: Midodrine hydrochloride, Midodrine hcl, Midodrine hydrochloride, Proamatine
Adverse Events
Top Adverse Reactions
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1,533 adverse events reported
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