Metyrosine
Demser, Metyrosine (metyrosine) is a small molecule pharmaceutical. Metyrosine was first approved as Demser on 1982-01-01. It is used to treat pheochromocytoma in the USA. The pharmaceutical is active against tyrosine 3-monooxygenase.
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Commercial
Trade Name
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EMA
Demser, Metyrosine
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metyrosine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DEMSER | Bausch Health Companies | N-017871 RX | 1982-01-01 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| demser | New Drug Application | 2021-07-01 |
| metyrosine | ANDA | 2023-01-11 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pheochromocytoma | — | D010673 | — |
Agency Specific
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Digeorge syndrome | D004062 | — | D82.1 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | — | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Metyrosine |
| INN | metirosine |
| Description | Alpha-methyl-L-tyrosine is an L-tyrosine derivative that consists of L-tyrosine bearing an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. It has a role as an antihypertensive agent and an EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor. It is a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@](N)(Cc1ccc(O)cc1)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 672-87-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200862 |
| ChEBI ID | 6912 |
| PubChem CID | 441350 |
| DrugBank | DB00765 |
| UNII ID | DOQ0J0TPF7 (ChemIDplus, GSRS) |
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Safety
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59 adverse events reported
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