Metyrapone
Metopirone (metyrapone) is a small molecule pharmaceutical. Metyrapone was first approved as Metopirone on 1982-01-01. The pharmaceutical is active against cytochrome P450 11B1, mitochondrial. In addition, it is known to target cytochrome P450 11B2, mitochondrial.
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Commercial
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Trade Name
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Metopirone (discontinued: Metopirone)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metyrapone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| METOPIRONE | HRA Pharma | N-012911 RX | 1996-08-09 | 1 products, RLD, RS |
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| metopirone | New Drug Application | 2023-11-13 |
Indications
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Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cushing syndrome | D003480 | EFO_0003099 | E24 | — | — | 1 | — | 1 | 2 |
| Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adrenocortical hyperfunction | D000308 | EFO_1000797 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Metyrapone |
| INN | metyrapone |
| Description | Metyrapone is an aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency. It has a role as a diagnostic agent, an antimetabolite and an EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(C(=O)c1cccnc1)c1cccnc1 |
Identifiers
| PDB | — |
| CAS-ID | 54-36-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL934 |
| ChEBI ID | 44241 |
| PubChem CID | 4174 |
| DrugBank | DB01011 |
| UNII ID | ZS9KD92H6V (ChemIDplus, GSRS) |
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Safety
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603 adverse events reported
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