Metoclopramide
Gimoti, Metoclopramide, Reglan (metoclopramide) is a small molecule pharmaceutical. Metoclopramide was first approved as Reglan on 1982-01-01. It is used to treat gastroesophageal reflux, gastroparesis, and postoperative nausea and vomiting in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 4 and D(2) dopamine receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Gimoti, Metoclopramide, Reglan (discontinued: Maxolon, Metoclopramide, Metozolv, Reglan)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metoclopramide hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| REGLAN | ANI Pharmaceuticals | N-017854 RX | 1982-01-01 | 2 products, RLD, RS |
| GIMOTI | Evoke Pharma | N-209388 RX | 2020-06-19 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| gimoti | New Drug Application | 2021-01-07 |
| metoclopramide | ANDA | 2025-05-07 |
| metoclopramide hydrochloride | ANDA | 2024-10-22 |
| reglan | New Drug Application | 2020-06-19 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| J2765 | Injection, metoclopramide hcl, up to 10 mg |
Clinical
Clinical Trials
206 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | — | R11.1 | — | — | 1 | 2 | — | 3 |
| Nausea | D009325 | — | R11.0 | — | — | 1 | 1 | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | 1 | — | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | 1 | — | 1 |
| Headache | D006261 | — | R51 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Metoclopramide |
| INN | metoclopramide |
| Description | Metoclopramide is a member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine. It has a role as an antiemetic, a dopaminergic antagonist, a gastrointestinal drug, a xenobiotic and an environmental contaminant. It is a tertiary amino compound, a substituted aniline, a member of benzamides and a member of monochlorobenzenes. It is a conjugate base of a metoclopramide(1+). |
| Classification | Small molecule |
| Drug class | D2 receptor antagonist; 5-HT3 receptor antagonist; 5-HT4 receptor agonist; Prolactin releaser |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 364-62-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL86 |
| ChEBI ID | 107736 |
| PubChem CID | 4168 |
| DrugBank | DB01233 |
| UNII ID | L4YEB44I46 (ChemIDplus, GSRS) |
Target
Agency Approved
HTR4
HTR4
DRD2
DRD2
Alternate
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Estimated US medical usage
Metoclopramide
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Trends
PubMed Central
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Additional graphs summarizing 14,378 documents
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Safety
Black-box Warning
Black-box warning for: Gimoti, Metoclopramide, Metoclopramide hydrochloride, Reglan
Adverse Events
Top Adverse Reactions
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33,757 adverse events reported
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