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Drug ReportsMetoclopramide
Metoclopramide
Gimoti, Metoclopramide, Reglan (metoclopramide) is a small molecule pharmaceutical. Metoclopramide was first approved as Reglan on 1982-01-01. It is used to treat gastroesophageal reflux, gastroparesis, and postoperative nausea and vomiting in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 4 and D(2) dopamine receptor.
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Target
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Financial
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Gimoti, Metoclopramide, Reglan (discontinued: Maxolon, Metoclopramide, Metozolv, Reglan)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metoclopramide hydrochloride
Tradename
Company
Number
Date
Products
REGLANANI PharmaceuticalsN-017854 RX1982-01-01
2 products, RLD, RS
GIMOTIEvoke PharmaN-209388 RX2020-06-19
1 products, RLD, RS
Show 4 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
gimotiNew Drug Application2021-01-07
metoclopramideANDA2025-06-10
metoclopramide hydrochlorideANDA2024-10-22
reglanNew Drug Application2020-06-19
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
postoperative nausea and vomitingEFO_0004888D020250—
gastroparesisEFO_1000948D018589K31.84
gastroesophageal refluxEFO_0003948D005764K21
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Metoclopramide Hydrochloride, Gimoti, Evoke Pharma Inc
83342812030-05-16DPU-2843
110203612029-12-22U-2843
116281502029-12-22DPU-2843
118132312029-12-22DPU-2843
ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03F: Propulsives
— A03FA: Propulsives
— A03FA01: Metoclopramide
HCPCS
Code
Description
J2765
Injection, metoclopramide hcl, up to 10 mg
Clinical
Clinical Trials
208 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GastroparesisD018589EFO_1000948K31.84—12——3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E13—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMetoclopramide
INNmetoclopramide
Description
Metoclopramide is a member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine. It has a role as an antiemetic, a dopaminergic antagonist, a gastrointestinal drug, a xenobiotic and an environmental contaminant. It is a tertiary amino compound, a substituted aniline, a member of benzamides and a member of monochlorobenzenes. It is a conjugate base of a metoclopramide(1+).
Classification
Small molecule
Drug classD2 receptor antagonist; 5-HT3 receptor antagonist; 5-HT4 receptor agonist; Prolactin releaser
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
Identifiers
PDB—
CAS-ID364-62-5
RxCUI—
ChEMBL IDCHEMBL86
ChEBI ID107736
PubChem CID4168
DrugBankDB01233
UNII IDL4YEB44I46 (ChemIDplus, GSRS)
Target
Agency Approved
HTR4
HTR4
DRD2
DRD2
Organism
Homo sapiens
Gene name
HTR4
Gene synonyms
NCBI Gene ID
3360
Protein name
5-hydroxytryptamine receptor 4
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled, cardiac 5-HT4 receptor, Serotonin receptor 4
Uniprot ID
Q9UQR6
Mouse ortholog
Htr4 (15562)
5-hydroxytryptamine receptor 4 (Q9R2A4)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Metoclopramide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14,442 documents
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Safety
Black-box Warning
Black-box warning for: Gimoti, Metoclopramide, Metoclopramide hydrochloride, Reglan
Adverse Events
Top Adverse Reactions
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34,119 adverse events reported
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