Methylergonovine
Methylergonovine (methylergonovine) is a small molecule pharmaceutical. Methylergonovine was first approved as Methergine on 1982-01-01. It is used to treat postpartum hemorrhage in the USA. It is known to target 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 1F, and 5-hydroxytryptamine receptor 2B.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Methylergonovine (discontinued: Methergine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methylergonovine maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| METHERGINE | Edison Pharmaceuticals | N-006035 DISCN | 1982-01-01 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| methergine | ANDA | 2024-03-20 |
| methylergonovine maleate | ANDA | 2025-07-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| postpartum hemorrhage | — | D006473 | O72 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2210 | Injection, methylergonovine maleate, up to 0.2 mg |
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postpartum hemorrhage | D006473 | — | O72 | 1 | — | — | 4 | 1 | 6 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | 4 | 1 | 5 |
| Uterine inertia | D014593 | EFO_1001863 | O62.2 | 1 | — | — | 3 | 1 | 5 |
| Cesarean section | D002585 | — | — | 1 | — | — | 1 | — | 2 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | 1 | — | 1 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | 1 | — | 1 |
| Pregnancy complications | D011248 | — | — | — | — | — | 1 | — | 1 |
| Twin pregnancy | D059285 | — | O30.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dystocia | D004420 | EFO_1000911 | O66.9 | — | — | — | — | 1 | 1 |
| Endometritis | D004716 | EFO_1001312 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methylergonovine |
| INN | methylergometrine |
| Description | (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide is an ergoline alkaloid. |
| Classification | Small molecule |
| Drug class | ergot alkaloid deriviatives; vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 |
Identifiers
| PDB | — |
| CAS-ID | 113-42-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201356 |
| ChEBI ID | — |
| PubChem CID | 8226 |
| DrugBank | DB00353 |
| UNII ID | W53L6FE61V (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Methylergonovine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 937 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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251 adverse events reported
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