Methyldopa
Aldoclor, Aldoril, Methyldopa (methyldopa) is a small molecule pharmaceutical. Methyldopa was first approved as Aldoclor-150 on 1982-01-01. It is used to treat hypertension in the USA. It is known to target aromatic-L-amino-acid decarboxylase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Methyldopa (discontinued: Aldomet, Methyldopa)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorothiazide
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Methyldopa
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ALDOCLOR-150 | Merck & Co | N-016016 DISCN | 1982-01-01 | 1 products |
| ALDOCLOR-250 | Merck & Co | N-016016 DISCN | 1982-01-01 | 1 products |
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Methyldopa
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| METHYLDOPA | Chartwell Pharmaceuticals | N-018934 DISCN | 1984-06-29 | 2 products |
| ALDOMET | Merck & Co | N-013400 DISCN | 1982-01-01 | 3 products, RLD |
| ALDOMET | Merck & Co | N-018389 DISCN | 1982-01-01 | 1 products |
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Hydrochlorothiazide
+
Methyldopa
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ALDORIL 15 | Merck & Co | N-013402 DISCN | 1982-01-01 | 1 products |
| ALDORIL 25 | Merck & Co | N-013402 DISCN | 1982-01-01 | 1 products |
| ALDORIL D30 | Merck & Co | N-013402 DISCN | 1982-01-01 | 1 products |
| ALDORIL D50 | Merck & Co | N-013402 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| methyldopa | NDA authorized generic | 2025-03-26 |
Agency Specific
FDA
EMA
No data
Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02A: Antiadrenergic agents, centrally acting
— C02AB: Methyldopa, centrally acting adntiadrenergic agents
— C02AB01: Methyldopa (levorotatory)
— C02AB02: Methyldopa (racemic)
— C02L: Antihypertensives and diuretics in combination
— C02LB: Methyldopa and diuretics in combination
— C02LB01: Methyldopa (levorotatory) and diuretics
HCPCS
Code | Description |
|---|---|
| J0210 | Injection, methyldopate hcl, up to 250 mg |
Clinical
Clinical Trials
30 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 1 | 2 | — | 5 | 3 | 10 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | — | 4 | 4 | 9 |
| Pregnancy-induced hypertension | D046110 | — | O13 | 1 | 1 | — | 3 | 3 | 7 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 3 | — | 1 | 1 | 5 |
| Eclampsia | D004461 | — | O15 | — | — | — | 3 | 2 | 5 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | 1 | — | 1 | 1 | 4 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nervous system diseases | D009422 | — | G00-G99 | 1 | 3 | — | — | — | 4 |
| Central nervous system diseases | D002493 | — | G96.9 | — | 3 | — | — | — | 3 |
| Movement disorders | D009069 | EFO_0004280 | G25 | — | 3 | — | — | — | 3 |
| Dyskinesias | D020820 | — | G24 | — | 3 | — | — | — | 3 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | 1 | — | — | 1 | 3 |
| Brain diseases | D001927 | — | G93.40 | — | 2 | — | — | — | 2 |
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | 2 | — | — | — | 2 |
| Brain injuries | D001930 | — | S06.9 | 1 | 1 | — | — | — | 1 |
| Consciousness disorders | D003244 | — | — | 1 | 1 | — | — | — | 1 |
| Proteinuria | D011507 | — | R80 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Orthostatic intolerance | D054971 | — | — | 2 | — | — | — | — | 2 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Primary dysautonomias | D054969 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | — | — | — | — | 1 |
| Fatigue | D005221 | — | R53.83 | 1 | — | — | — | — | 1 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | 1 | — | — | — | — | 1 |
| Tachycardia | D013610 | — | R00.0 | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Hellp syndrome | D017359 | EFO_0007297 | O14.2 | — | — | — | — | 1 | 1 |
| Transcranial magnetic stimulation | D050781 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methyldopa |
| INN | methyldopa |
| Description | Alpha-methyl-L-dopa is a derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring. It has a role as a hapten, an antihypertensive agent, an alpha-adrenergic agonist, a peripheral nervous system drug and a sympatholytic agent. It is a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid. |
| Classification | Small molecule |
| Drug class | dopamine receptor agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 555-30-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL459 |
| ChEBI ID | 61058 |
| PubChem CID | 38853 |
| DrugBank | DB00968 |
| UNII ID | M4R0H12F6M (ChemIDplus, GSRS) |
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Estimated US medical usage
Methyldopa
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Chlorothiazide
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Methyldopa
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Hydrochlorothiazide
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Methyldopa
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Safety
Black-box Warning
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3,395 adverse events reported
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