Methylcobalamin
Methylcobalamin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| embriva | unapproved drug other | 2025-08-12 |
| healthy mamabe well rounded | unapproved drug other | 2013-07-09 |
| matervia | unapproved drug other | 2025-06-11 |
| methylcobalamin | unapproved drug other | 2015-11-20 |
Indications
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EMA
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Agency Specific
FDA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
584 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 3 | 2 | — | — | — | 4 |
| T-cell lymphoma peripheral | D016411 | — | — | 1 | 3 | — | — | — | 3 |
| Lymphoma | D008223 | — | C85.9 | 2 | 2 | — | — | — | 3 |
| T-cell lymphoma | D016399 | — | — | 2 | 2 | — | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | 1 | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | — | 1 | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sezary syndrome | D012751 | — | C84.1 | 2 | — | — | — | — | 2 |
| Mycosis fungoides | D009182 | — | C84.0 | 2 | — | — | — | — | 2 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 2 | — | — | — | — | 2 |
| Primary cutaneous anaplastic large cell lymphoma | D054446 | — | C86.6 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methylcobalamin |
| INN | mecobalamin |
| Description | Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin, a form of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of coordination chemistry, methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. Nickel–methyl intermediates have been proposed for the final step of methanogenesis.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 13422-55-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297672 |
| ChEBI ID | — |
| PubChem CID | 6436232 |
| DrugBank | DB03614 |
| UNII ID | BR1SN1JS2W (ChemIDplus, GSRS) |
Target
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Financial
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Estimated US medical usage
Methylcobalamin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 4,310 documents
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Safety
Black-box Warning
Black-box warning for: Healthy mamabe well rounded
Adverse Events
Top Adverse Reactions
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673 adverse events reported
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