Methylcobalamin
Methylcobalamin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Labels
FDA
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Brand Name | Status | Last Update |
|---|---|---|
| healthy mamabe well rounded | unapproved drug other | 2013-07-09 |
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Clinical
Clinical Trials
487 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | 2 | 4 | 2 | 4 | 32 | 42 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 3 | 4 | 4 | 21 | 30 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | 1 | 1 | 1 | 9 | 13 |
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | — | — | — | 3 | 6 | 9 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 1 | 1 | — | 1 | 5 | 8 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | 1 | 4 | 7 |
| Neoplasms | D009369 | — | C80 | 1 | — | 2 | 1 | 1 | 5 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | 1 | 1 | 3 | 5 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | 1 | 2 | 1 | 4 |
| Iron deficiencies | D000090463 | — | E61.1 | — | — | — | 1 | 3 | 4 |
Show 31 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 12 | 7 | — | 2 | 20 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 2 | 1 | — | 9 | 11 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 1 | — | 7 | 9 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 2 | 3 | — | 3 | 8 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 3 | 2 | — | 4 | 8 |
| Hyperhomocysteinemia | D020138 | — | — | — | 1 | 1 | — | 6 | 8 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 3 | 2 | — | 5 | 8 |
| T-cell lymphoma peripheral | D016411 | — | — | 2 | 4 | 2 | — | — | 6 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 5 | 1 | — | — | 5 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | 1 | 1 | — | 4 | 5 |
Show 49 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | 2 | — | — | 8 | 11 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | 1 | — | — | 3 | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | 1 | 3 |
| Nasopharyngeal neoplasms | D009303 | — | — | — | 3 | — | — | — | 3 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 2 | — | — | — | 2 |
| Malignant mesothelioma | D000086002 | — | — | — | 2 | — | — | — | 2 |
| B-cell lymphoma | D016393 | — | — | 1 | 2 | — | — | — | 2 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | 1 | 1 | — | — | 1 | 2 |
| Coronary disease | D003327 | — | — | — | 1 | — | — | — | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | — | 1 |
Show 27 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | 4 | 5 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | 2 | 3 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 2 | — | — | — | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | 1 | 2 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | — | 1 | 2 |
| Birth weight | D001724 | EFO_0004344 | — | 1 | — | — | — | 1 | 2 |
| Chordoma | D002817 | EFO_0000334 | — | 1 | — | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Heart rate | D006339 | EFO_0004326 | — | 1 | — | — | — | — | 1 |
| Sezary syndrome | D012751 | — | C84.1 | 1 | — | — | — | — | 1 |
Show 4 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | — | — | 5 | 5 |
| Gyrate atrophy | D015799 | — | — | — | — | — | — | 4 | 4 |
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | — | — | — | — | 3 | 3 |
| Folic acid deficiency | D005494 | EFO_0001070 | E53.8 | — | — | — | — | 3 | 3 |
| Diet therapy | D004035 | — | — | — | — | — | — | 2 | 2 |
| Diabetes complications | D048909 | — | — | — | — | — | — | 2 | 2 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | — | 2 | 2 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | — | — | 2 | 2 |
| Delirium | D003693 | — | R41.0 | — | — | — | — | 2 | 2 |
| Child development | D002657 | — | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methylcobalamin |
| INN | mecobalamin |
| Description | Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin, a form of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of coordination chemistry, methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. Nickel–methyl intermediates have been proposed for the final step of methanogenesis.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 13422-55-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297672 |
| ChEBI ID | — |
| PubChem CID | 6436232 |
| DrugBank | DB03614 |
| UNII ID | BR1SN1JS2W (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Methylcobalamin
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Trends
PubMed Central
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Additional graphs summarizing 3,431 documents
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Safety
Black-box Warning
Black-box warning for: Healthy mamabe well rounded
Adverse Events
Top Adverse Reactions
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352 adverse events reported
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