Methylcobalamin - PharmaKB

Methylcobalamin

Methylcobalamin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.

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Events

FDA approval date

EMA approval date

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Study first post date

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EMA

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Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

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Labels

FDA

EMA

Brand Name	Status	Last Update
healthy mamabe well rounded	unapproved drug other	2013-07-09
matervia	unapproved drug other	2025-06-11
methylcobalamin	unapproved drug other	2015-11-20

Indications

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EMA

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Agency Specific

FDA

EMA

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Patent Expiration

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ATC Codes

B: Blood and blood forming organ drugs

— B03: Antianemic preparations

— B03B: Vitamin b12 and folic acid

— B03BA: Vitamin b12 (cyanocobalamin and analogues)

— B03BA05: Mecobalamin

HCPCS

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Clinical

Clinical Trials

573 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Vitamin b 12 deficiency	D014806	EFO_0000734	E53.8	2	4	2	4	42	52
Anemia	D000740	EFO_0004272	D64.9	—	3	5	6	27	39
Peripheral nervous system diseases	D010523	—	G64	1	2	—	5	12	20
Iron deficiencies	D000090463	—	E61.1	—	—	—	4	14	18
Diabetic neuropathies	D003929	EFO_1000783	—	1	2	1	1	12	17
Iron-deficiency anemia	D018798	—	D50	—	—	—	4	11	15
Diabetes mellitus	D003920	EFO_0000400	E08-E13	—	4	3	2	7	14
Cognitive dysfunction	D060825	—	G31.84	1	2	—	1	10	14
Hyperhomocysteinemia	D020138	—	—	—	1	1	1	10	13
Avitaminosis	D001361	EFO_0005878	E56.9	—	2	3	1	8	12

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Non-small-cell lung carcinoma	D002289	—	—	1	13	7	—	2	21
Lung neoplasms	D008175	—	C34.90	—	13	5	—	2	19
Malnutrition	D044342	EFO_0008572	E40-E46	—	2	1	—	16	18
Syndrome	D013577	—	—	—	2	5	—	7	12
Type 2 diabetes mellitus	D003924	EFO_0001360	E11	—	4	2	—	7	11
Lymphoma	D008223	—	C85.9	5	6	2	—	—	10
T-cell lymphoma	D016399	—	—	5	5	2	—	—	9
Parkinson disease	D010300	EFO_0002508	G20	—	1	1	—	8	9
Pregnancy	D011247	EFO_0002950	Z33.1	1	—	1	—	7	9
Covid-19	D000086382	—	U07.1	1	2	3	—	3	8

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Healthy volunteers/patients	—	—	—	1	2	—	—	9	12
Stomatitis	D013280	EFO_1001904	K12.1	—	3	—	—	2	5
Breast neoplasms	D001943	EFO_0003869	C50	—	3	—	—	2	5
Diarrhea	D003967	—	R19.7	—	1	—	—	4	5
Mucositis	D052016	EFO_1001898	—	—	4	—	—	—	4
Micronutrients	D018977	—	—	—	1	—	—	3	4
Fibromyalgia	D005356	EFO_0005687	M79.1	2	1	—	—	2	4
Heart diseases	D006331	EFO_0003777	I51.9	—	2	—	—	1	3
Nasopharyngeal carcinoma	D000077274	—	—	—	3	—	—	—	3
Nasopharyngeal neoplasms	D009303	—	—	—	3	—	—	—	3

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Weight loss	D015431	—	—	1	—	—	—	4	5
Child development	D002657	—	—	1	—	—	—	2	3
Heart failure	D006333	EFO_0003144	I50	1	—	—	—	2	3
T-cell lymphoma cutaneous	D016410	—	C84.A	2	—	—	—	—	2
Multiple sclerosis	D009103	EFO_0003885	G35	1	—	—	—	1	2
Glioma	D005910	EFO_0000520	—	1	—	—	—	—	1
Colorectal neoplasms	D015179	—	—	1	—	—	—	—	1
Heart rate	D006339	EFO_0004326	—	1	—	—	—	—	1
Mycoses	D009181	—	B35-B49	1	—	—	—	—	1
Sezary syndrome	D012751	—	C84.1	1	—	—	—	—	1

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Folic acid deficiency	D005494	EFO_0001070	E53.8	—	—	—	—	10	10
Deglutition disorders	D003680	—	R13.1	—	—	—	—	8	8
Gyrate atrophy	D015799	—	—	—	—	—	—	6	6
Infertility	D007246	EFO_0000545	—	—	—	—	—	6	6
Gastroesophageal reflux	D005764	EFO_0003948	K21	—	—	—	—	6	6
Male infertility	D007248	EFO_0004248	N46	—	—	—	—	5	5
Vitamin a deficiency	D014802	EFO_1001237	E50	—	—	—	—	5	5
Metabolic syndrome	D024821	EFO_0000195	E88.810	—	—	—	—	4	4
Fatigue	D005221	—	R53.83	—	—	—	—	4	4
Cerebral palsy	D002547	—	G80	—	—	—	—	4	4

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Methylcobalamin
INN	mecobalamin
Description	Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin, a form of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of coordination chemistry, methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. Nickel–methyl intermediates have been proposed for the final step of methanogenesis.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	—