Tradename | Company | Number | Date | Products |
---|---|---|---|---|
RASUVO | Medexus Pharmaceuticals | N-205776 RX | 2014-07-10 | 9 products, RLD, RS |
JYLAMVO | Shorla Pharma | N-212479 RX | 2022-11-29 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
jylamvo | New Drug Application | 2025-04-28 |
methotrexate | ANDA | 2025-09-15 |
methotrexate sodium | ANDA | 2024-03-01 |
otrexup | New Drug Application | 2025-01-31 |
rasuvo | New Drug Application | 2024-12-06 |
trexall | ANDA | 2021-04-30 |
xatmep | New Drug Application | 2022-06-28 |
Expiration | Code | ||
---|---|---|---|
METHOTREXATE SODIUM, XATMEP, AZURITY | |||
2024-04-25 | ODE-137, ODE-138 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Methotrexate Sodium, Xatmep, Azurity | |||
9259427 | 2033-01-02 | DP | |
9855215 | 2033-01-02 | DP | |
10231927 | 2033-01-02 | U-1349, U-1699 | |
10610485 | 2033-01-02 | DP | |
11116724 | 2033-01-02 | U-1349, U-1699 | |
Methotrexate, Otrexup, Otter Pharms | |||
8814834 | 2031-05-27 | DP | |
8480631 | 2030-03-19 | DP | U-1442 |
8579865 | 2030-03-19 | DP | U-1442 |
8945063 | 2030-03-19 | DP | U-1442 |
9421333 | 2030-03-19 | DP | U-1442 |
11497753 | 2030-03-19 | DP | |
9867949 | 2029-03-10 | DP | |
10709844 | 2029-03-10 | DP | |
8021335 | 2026-10-04 | DP | |
8562564 | 2026-01-24 | DP | |
9533102 | 2026-01-24 | DP | |
9629959 | 2026-01-24 | DP | |
11446441 | 2026-01-24 | DP | |
Methotrexate, Rasuvo, Medexus | |||
8664231 | 2029-06-01 | U-1442 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 72 | 232 | 215 | 126 | 86 | 702 |
Arthritis | D001168 | EFO_0005856 | M05-M14 | 65 | 187 | 144 | 71 | 81 | 523 |
Leukemia | D007938 | — | C95 | 70 | 224 | 94 | 19 | 34 | 387 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 67 | 183 | 84 | 21 | 35 | 348 |
Lymphoma | D008223 | — | C85.9 | 48 | 178 | 54 | 11 | 29 | 287 |
Lymphoid leukemia | D007945 | — | C91 | 31 | 97 | 44 | 15 | 17 | 188 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 22 | 65 | 29 | 3 | 8 | 114 |
Graft vs host disease | D006086 | — | D89.81 | 18 | 57 | 22 | 3 | 6 | 92 |
Psoriasis | D011565 | EFO_0000676 | L40 | 6 | 6 | 14 | 23 | 31 | 77 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 6 | 28 | 32 | 1 | 8 | 72 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myelodysplastic syndromes | D009190 | — | D46 | 31 | 72 | 19 | — | 7 | 113 |
Myeloid leukemia acute | D015470 | — | C92.0 | 33 | 61 | 25 | — | 5 | 111 |
Myeloid leukemia | D007951 | — | C92 | 13 | 32 | 14 | — | 4 | 57 |
Neoplasms | D009369 | — | C80 | 14 | 32 | 6 | — | 13 | 56 |
Myeloproliferative disorders | D009196 | — | D47.1 | 9 | 40 | 4 | — | 4 | 50 |
Preleukemia | D011289 | — | — | 10 | 32 | 10 | — | 4 | 48 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 7 | 31 | 7 | — | 2 | 44 |
Multiple myeloma | D009101 | — | C90.0 | 12 | 31 | 2 | — | 4 | 43 |
Osteosarcoma | D012516 | — | — | 8 | 22 | 7 | — | 10 | 43 |
Hodgkin disease | D006689 | — | C81 | 8 | 23 | 6 | — | 3 | 37 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Blast crisis | D001752 | — | — | 4 | 22 | — | — | 1 | 24 |
Primary myelofibrosis | D055728 | — | D47.4 | 5 | 13 | — | — | 3 | 20 |
Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 3 | 12 | — | — | 2 | 15 |
Plasmacytoma | D010954 | — | C90.3 | 2 | 12 | — | — | 2 | 14 |
Healthy volunteers/patients | — | — | — | 11 | 1 | — | — | 1 | 13 |
Waldenstrom macroglobulinemia | D008258 | — | C88.0 | 4 | 7 | — | — | 2 | 11 |
Sezary syndrome | D012751 | — | C84.1 | 2 | 7 | — | — | 2 | 10 |
Neurotoxicity syndromes | D020258 | — | G92 | 2 | 3 | — | — | 5 | 9 |
Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 1 | 5 | — | — | 2 | 8 |
Invasive hydatidiform mole | D002820 | — | D39.2 | 2 | 4 | — | — | 1 | 7 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Dermatitis | D003872 | — | L30.9 | 1 | — | — | — | 2 | 3 |
Drug interactions | D004347 | — | — | 3 | — | — | — | — | 3 |
Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
Photosensitivity disorders | D010787 | — | L57.1 | 1 | — | — | — | 1 | 2 |
Male breast neoplasms | D018567 | — | — | 1 | — | — | — | — | 1 |
Headache | D006261 | — | R51 | 1 | — | — | — | — | 1 |
Neck pain | D019547 | — | M54.2 | 1 | — | — | — | — | 1 |
Sleep wake disorders | D012893 | — | G47 | 1 | — | — | — | — | 1 |
Plasma cell leukemia | D007952 | — | C90.1 | 1 | — | — | — | — | 1 |
Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Alopecia | D000505 | — | L64 | — | — | — | — | 6 | 6 |
Eczema | D004485 | — | L30.9 | — | — | — | — | 2 | 2 |
Rheumatic fever | D012213 | EFO_1001160 | I00-I02 | — | — | — | — | 2 | 2 |
Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 2 | 2 |
Chediak-higashi syndrome | D002609 | Orphanet_167 | D72.0 | — | — | — | — | 2 | 2 |
Hair diseases | D006201 | — | — | — | — | — | — | 2 | 2 |
Localized scleroderma | D012594 | EFO_1001361 | L94.0 | — | — | — | — | 1 | 1 |
Papillomaviridae | D027383 | — | — | — | — | — | — | 1 | 1 |
Osteomyelitis | D010019 | EFO_0003102 | M86 | — | — | — | — | 1 | 1 |
Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 1 | 1 |
Drug common name | Methotrexate |
INN | methotrexate |
Description | Methotrexate is a member of pteridines, a monocarboxylic acid amide and a dicarboxylic acid. It has a role as an antineoplastic agent, an antirheumatic drug, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, a DNA synthesis inhibitor, an abortifacient, a dermatologic drug, an antimetabolite and an immunosuppressive agent. It is functionally related to a L-glutamic acid. It is a conjugate acid of a methotrexate(1-). |
Classification | Small molecule |
Drug class | antimetabolites (folic acid derivatives) |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 |
PDB | — |
CAS-ID | 59-05-2 |
RxCUI | — |
ChEMBL ID | CHEMBL34259 |
ChEBI ID | 44185 |
PubChem CID | 126941 |
DrugBank | DB00563 |
UNII ID | YL5FZ2Y5U1 (ChemIDplus, GSRS) |