Methocarbamol
Methocarbamol, Robaxin, Robaxisal (methocarbamol) is a small molecule pharmaceutical. Methocarbamol was first approved as Robaxisal on 1982-01-01. It is used to treat muscle cramp, muscle rigidity, myositis, pain, and spasm amongst others in the USA. It is known to target carbonic anhydrase 1.
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Commercial
Trade Name
FDA
EMA
Robaxin (generic drugs available since 1982-01-01, discontinued: Delaxin, Forbaxin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
+
Methocarbamol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ROBAXISAL | A.H. Robins Company | N-012281 DISCN | 1982-01-01 | 1 products, RLD |
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Methocarbamol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ROBAXIN | Hikma Pharmaceuticals | N-011790 RX | 1982-01-01 | 1 products, RLD, RS |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| methocarbamol and aspirin | ANDA | 2021-03-11 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M03: Muscle relaxants
— M03B: Muscle relaxants, centrally acting agents
— M03BA: Carbamic acid esters, centrally acting muscle relaxants
— M03BA03: Methocarbamol
— M03BA53: Methocarbamol, combinations excl. psycholeptics
— M03BA73: Methocarbamol, combinations with psycholeptics
HCPCS
Code | Description |
|---|---|
| J2800 | Injection, methocarbamol, up to 10 ml |
Clinical
Clinical Trials
30 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | 1 | 2 | 1 | 4 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | 1 | 1 | 2 |
| Rib fractures | D012253 | — | — | — | — | — | 1 | 1 | 2 |
| Postoperative pain | D010149 | — | G89.18 | — | — | 1 | 1 | — | 2 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | — | 1 | — | 1 |
| Chronic pain | D059350 | HP_0012532 | — | — | — | — | 1 | — | 1 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | 1 | — | 1 |
| Spinal diseases | D013122 | — | M45-M49 | — | — | — | 1 | — | 1 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | — | — | 1 | — | 1 |
| Ventral hernia | D006555 | EFO_1001866 | K43 | — | — | — | 1 | — | 1 |
Show 4 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | — | 4 | 1 | — | — | 4 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | 1 | 1 | — | — | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | 1 | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | — | — | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | — | — | — | 1 |
| Induced labor | D007751 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Assisted reproductive techniques | D027724 | — | — | — | — | — | — | 1 | 1 |
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 1 | 1 |
| Multiple trauma | D009104 | — | T07 | — | — | — | — | 1 | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
| Nephrolithiasis | D053040 | — | N20.0 | — | — | — | — | 1 | 1 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | — | — | 1 | 1 |
| Urolithiasis | D052878 | — | N20-N23 | — | — | — | — | 1 | 1 |
| Ureteral calculi | D014514 | — | — | — | — | — | — | 1 | 1 |
| Ureteral diseases | D014515 | — | — | — | — | — | — | 1 | 1 |
Show 1 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methocarbamol |
| INN | methocarbamol |
| Description | 2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate is a carbamate ester that is glycerol in which one of the primary alcohol groups has been converted to its 2-methoxyphenyl ether while the other has been converted to the corresponding carbamate ester. It is a carbamate ester, a secondary alcohol and an aromatic ether. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccccc1OCC(O)COC(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 108914-10-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201117 |
| ChEBI ID | 77498 |
| PubChem CID | 4107 |
| DrugBank | DB00423 |
| UNII ID | 125OD7737X (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CA1
CA1
Organism
Homo sapiens
Gene name
CA1
Gene synonyms
NCBI Gene ID
Protein name
carbonic anhydrase 1
Protein synonyms
CA-I, CAB, Carbonate dehydratase I, Carbonic anhydrase B, Carbonic anhydrase I, Cyanamide hydratase CA1, epididymis secretory protein Li 11, epididymis secretory sperm binding protein
Uniprot ID
Mouse ortholog
Car1 (12346)
carbonic anhydrase 1 (Q9DC84)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Methocarbamol
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Aspirin
Total medical expenditures per year (USD, in millions)
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Methocarbamol
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 859 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,924 adverse events reported
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