Methimazole
Methimazole (methimazole) is a small molecule pharmaceutical. Methimazole was first approved as Tapazole on 1982-01-01. It is used to treat goiter and thyroid crisis in the USA. The pharmaceutical is active against thyroid peroxidase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
Methimazole (discontinued: Methimazole, Tapazole)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methimazole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TAPAZOLE | King Pharmaceuticals | N-007517 DISCN | 1982-01-01 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| methimazole | ANDA | 2024-09-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| goiter | HP_0000853 | D006042 | E04.9 |
| thyroid crisis | EFO_1001212 | D013958 | E05.5 |
Agency Specific
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Clinical
Clinical Trials
36 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graves disease | D006111 | EFO_0004237 | E05.0 | 1 | 3 | 3 | 5 | 9 | 19 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | — | 1 | 1 | 2 | 1 | 1 | 5 |
| Recurrence | D012008 | — | — | 1 | 1 | — | 2 | — | 4 |
| Eye diseases | D005128 | EFO_0003966 | H44 | 1 | 1 | 1 | 1 | 1 | 4 |
| Goiter | D006042 | HP_0000853 | E04.9 | — | — | — | 2 | 1 | 3 |
| Nodular goiter | D006044 | EFO_1001062 | — | — | — | — | 2 | — | 2 |
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | — | 1 |
| Substance withdrawal syndrome | D013375 | EFO_0005800 | — | — | — | — | 1 | — | 1 |
| Therapeutics | D013812 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperthyroidism | D006980 | — | E05.9 | 1 | — | 2 | — | 8 | 11 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 1 | — | — | 1 |
| Pathologic processes | D010335 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | — | 3 |
| Thyrotoxicosis | D013971 | — | E05.9 | — | 1 | — | — | 1 | 2 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | 1 | — | — | 1 | 2 |
| Dermatomyositis | D003882 | EFO_0000398 | M33 | — | 1 | — | — | — | 1 |
| Polymyositis | D017285 | EFO_0003063 | M33.2 | — | 1 | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanosis | D008548 | HP_0001480 | L81.1 | 1 | — | — | — | — | 1 |
| Gliosarcoma | D018316 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Microbiota | D064307 | — | — | — | — | — | — | 2 | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Autoimmune thyroiditis | D013967 | EFO_0006812 | E06.3 | — | — | — | — | 1 | 1 |
| Thyroiditis | D013966 | — | E06 | — | — | — | — | 1 | 1 |
| Hashimoto disease | D050031 | EFO_0003779 | E06.3 | — | — | — | — | 1 | 1 |
| Gastrointestinal microbiome | D000069196 | — | — | — | — | — | — | 1 | 1 |
| Patient acceptance of health care | D010342 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methimazole |
| INN | thiamazole |
| Description | Methimazole is a member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen. It has a role as an antithyroid drug. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1ccnc1S |
Identifiers
| PDB | — |
| CAS-ID | 60-56-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1515 |
| ChEBI ID | 50673 |
| PubChem CID | 1349907 |
| DrugBank | DB00763 |
| UNII ID | 554Z48XN5E (ChemIDplus, GSRS) |
Target
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Estimated US medical usage
Methimazole
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Safety
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2,876 adverse events reported
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