Methenamine
Hiprex, Methenamine Hippurate, Urex (methenamine) is a small molecule pharmaceutical. Methenamine was first approved as Urex on 1982-01-01. It is used to treat bacteriuria, cystitis, escherichia coli infections, and staphylococcal infections in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| all-in-one uti emergency kit | unapproved drug other | 2025-11-10 |
| azo urinary tract defense | unapproved drug other | 2020-12-12 |
| cvs antibacterial plus urinary pain relief | unapproved drug other | 2024-12-18 |
| cvs dual action pain relief | unapproved drug other | 2024-12-18 |
| cystex | C200263 | 2024-12-20 |
| good neighbor antibacterial plus urinary pain relief | unapproved drug other | 2024-12-18 |
| hiprex | New Drug Application | 2022-02-02 |
| hyophen | unapproved drug other | 2017-01-05 |
| mb caps | unapproved drug other | 2025-02-25 |
| meijer antibacterial plus urinary pain relief | unapproved drug other | 2024-12-18 |
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Indications
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Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | 1 | 2 | — | 6 | 4 | 13 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | 3 | 4 | 8 |
| Communicable diseases | D003141 | — | — | — | — | — | 1 | 3 | 4 |
| Recurrence | D012008 | — | — | — | — | — | 2 | 1 | 3 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 1 | — | — | 1 | — | 2 |
| Reinfection | D000084063 | — | — | — | — | — | 1 | — | 1 |
| Female urogenital diseases | D052776 | — | — | — | — | — | 1 | — | 1 |
| Urogenital diseases | D000091642 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dysuria | D053159 | EFO_0003901 | R30 | — | — | 1 | — | — | 1 |
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary retention | D016055 | — | R33 | — | 1 | — | — | — | 1 |
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | — | 1 | — | — | — | 1 |
| Prolapse | D011391 | — | — | — | 1 | — | — | — | 1 |
| Spinal dysraphism | D016135 | EFO_1001210 | Q05 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Bacteriuria | D001437 | — | R82.71 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 1 | 1 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 1 | 1 |
| Catheter-related infections | D055499 | — | — | — | — | — | — | 1 | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 1 | 1 |
| Hypercholesterolemia | D006937 | — | — | — | — | — | — | 1 | 1 |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | — | — | — | — | 1 | 1 |
| Hyperlipoproteinemia type ii | D006938 | EFO_0004911 | E78.00 | — | — | — | — | 1 | 1 |
| Bone diseases | D001847 | — | M89.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methenamine |
| INN | methenamine |
| Description | Hexamethylenetetramine is a polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms. It has a role as an antibacterial drug. It is a polycyclic cage, a polyazaalkane and a tetramine. |
| Classification | Small molecule |
| Drug class | Antiseptic; Antibacterial |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C1N2CN3CN1CN(C2)C3 |
Identifiers
| PDB | — |
| CAS-ID | 100-97-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201270 |
| ChEBI ID | 6824 |
| PubChem CID | 4101 |
| DrugBank | DB06799 |
| UNII ID | J50OIX95QV (ChemIDplus, GSRS) |
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Methenamine
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Safety
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453 adverse events reported
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