Methamphetamine
Desoxyn, Methamphetamine (methamphetamine) is a small molecule pharmaceutical. Methamphetamine was first approved as Desoxyn on 1982-01-01. It is used to treat attention deficit disorder with hyperactivity, narcolepsy, and obesity in the USA.
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Trade Name
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Desoxyn, Methamphetamine (discontinued: Desoxyn, Methampex, Methamphetamine)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methamphetamine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DESOXYN | Key Therapeutics | N-005378 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| methamphetamine hydrochloride | ANDA | 2024-12-10 |
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Clinical
Clinical Trials
390 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 14 | 19 | 3 | 3 | 26 | 61 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 8 | — | 2 | 10 | 20 |
| Depression | D003863 | — | F33.9 | 1 | — | 1 | 3 | 4 | 9 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 1 | — | — | 3 | 4 | 8 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | 1 | — | 1 | 4 | 6 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | 1 | 4 | 5 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | 1 | 2 | 3 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | — | 2 | 1 | 3 |
| Problem behavior | D000066553 | — | — | — | — | — | 1 | 2 | 3 |
| Recurrence | D012008 | — | — | — | 1 | — | 1 | 1 | 3 |
Show 17 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 1 | 1 | — | 2 | 4 |
| Drug overdose | D062787 | — | — | — | 2 | 1 | — | 1 | 3 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 1 | 1 | — | 1 | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 1 | — | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | 1 | — | — | 1 |
| Substance withdrawal syndrome | D013375 | EFO_0005800 | — | — | 1 | 1 | — | — | 1 |
| Critical illness | D016638 | — | — | — | — | 1 | — | — | 1 |
| Acute kidney injury | D058186 | — | N17 | — | — | 1 | — | — | 1 |
| Pain management | D059408 | — | — | — | — | 1 | — | — | 1 |
| Periodontal diseases | D010510 | — | K05.6 | — | 1 | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 11 | 13 | — | — | 14 | 36 |
| Addictive behavior | D016739 | EFO_0004347 | — | 2 | 5 | — | — | 9 | 16 |
| Hiv | D006678 | — | O98.7 | 2 | 4 | — | — | 8 | 12 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 1 | — | — | 5 | 7 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | 5 | 6 |
| Sexually transmitted diseases | D012749 | — | A50-A64 | 1 | 2 | — | — | 1 | 4 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 2 | — | — | 1 | 3 |
| Hiv seropositivity | D006679 | — | — | — | 1 | — | — | 1 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | 1 | 2 |
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | — | — | 1 | 2 |
Show 14 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental caries | D003731 | EFO_0003819 | K02 | 2 | — | — | — | 16 | 18 |
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | 3 | 7 |
| Root caries | D017213 | EFO_1001163 | — | 1 | — | — | — | 2 | 3 |
| Dental restoration failure | D019232 | — | — | 1 | — | — | — | 1 | 2 |
| Affect | D000339 | — | — | 1 | — | — | — | 1 | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Second primary neoplasms | D016609 | — | — | 1 | — | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
| Rectal neoplasms | D012004 | — | — | 1 | — | — | — | — | 1 |
Show 9 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fatigue | D005221 | — | R53.83 | — | — | — | — | 4 | 4 |
| Sleep wake disorders | D012893 | — | G47 | — | — | — | — | 4 | 4 |
| Cocaine-related disorders | D019970 | — | F14 | — | — | — | — | 4 | 4 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 4 | 4 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 4 | 4 |
| Parasomnias | D020447 | — | G47.5 | — | — | — | — | 3 | 3 |
| Medication adherence | D055118 | EFO_0006344 | — | — | — | — | — | 3 | 3 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 3 | 3 |
| Amblyopia | D000550 | — | H53.00 | — | — | — | — | 3 | 3 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methamphetamine |
| INN | metamfetamine |
| Description | Methamphetamine[note 1] (contracted from N-methylamphetamine) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine.[note 2] Methamphetamine properly refers to a specific chemical substance, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms, but the hydrochloride salt, commonly called crystal meth, is widely used. Methamphetamine is rarely prescribed over concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy such as Adderall and Vyvanse. Dextromethamphetamine is a stronger CNS stimulant than levomethamphetamine.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN[C@@H](C)Cc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 537-46-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201201 |
| ChEBI ID | 6809 |
| PubChem CID | 1206 |
| DrugBank | DB01577 |
| UNII ID | 44RAL3456C (ChemIDplus, GSRS) |
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Methamphetamine
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Safety
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10,204 adverse events reported
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