Methamphetamine
Desoxyn, Methamphetamine (methamphetamine) is a small molecule pharmaceutical. Methamphetamine was first approved as Desoxyn on 1982-01-01. It is used to treat attention deficit disorder with hyperactivity, narcolepsy, and obesity in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Desoxyn, Methamphetamine (discontinued: Desoxyn, Methampex, Methamphetamine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methamphetamine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DESOXYN | Key Therapeutics | N-005378 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| methamphetamine hydrochloride | ANDA | 2024-12-10 |
Indications
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
258 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 14 | 20 | 4 | 3 | 25 | 61 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 8 | — | 2 | 10 | 20 |
| Depression | D003863 | — | F33.9 | 1 | — | 1 | 3 | 3 | 8 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 1 | — | — | 3 | 2 | 6 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | 1 | — | 1 | 4 | 6 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | — | 2 | 1 | 3 |
| Recurrence | D012008 | — | — | — | 1 | — | 1 | 1 | 3 |
| Dual (psychiatry) diagnosis | D017831 | — | — | — | — | — | 2 | 1 | 3 |
| Hyperkinesis | D006948 | — | — | — | — | — | 1 | 1 | 2 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | — | — | 1 | 1 | 2 |
Show 8 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug overdose | D062787 | — | — | — | 2 | 1 | — | 1 | 3 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 1 | 1 | — | — | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 1 | — | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 10 | 13 | — | — | 14 | 35 |
| Addictive behavior | D016739 | EFO_0004347 | — | 3 | 5 | — | — | 9 | 17 |
| Hiv | D006678 | — | O98.7 | 2 | 4 | — | — | 8 | 12 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | 4 | 5 |
| Sexually transmitted diseases | D012749 | — | A50-A64 | 1 | 2 | — | — | 1 | 4 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 2 | — | — | 1 | 3 |
| Hiv seropositivity | D006679 | — | — | — | 1 | — | — | 1 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | 1 | 2 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | 1 | — | — | 1 | 2 |
| Pharmacogenomic testing | D000071185 | — | — | — | 1 | — | — | — | 1 |
Show 7 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | 2 | 6 |
| Cognition | D003071 | EFO_0003925 | — | 1 | — | — | — | — | 1 |
| Cardiovascular abnormalities | D018376 | EFO_0003848 | — | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Homosexuality | D006716 | — | — | 1 | — | — | — | — | 1 |
| Affect | D000339 | — | — | 1 | — | — | — | — | 1 |
| Sexual abstinence | D012746 | — | — | 1 | — | — | — | — | 1 |
| Chemically-induced disorders | D064419 | — | — | 1 | — | — | — | — | 1 |
| Motivation | D009042 | — | — | 1 | — | — | — | — | 1 |
| Social behavior | D012919 | — | STY/T054 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | — | — | — | — | 4 | 4 |
| Medication adherence | D055118 | EFO_0006344 | — | — | — | — | — | 3 | 3 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | — | 2 | 2 |
| Recreational drug use | D000084783 | — | — | — | — | — | — | 2 | 2 |
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 2 | 2 |
| Craving | D066249 | — | — | — | — | — | — | 2 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 1 | 1 |
| Familial primary pulmonary hypertension | D065627 | — | I27.0 | — | — | — | — | 1 | 1 |
| Mobility limitation | D051346 | — | — | — | — | — | — | 1 | 1 |
| Humans | D006801 | — | STY/T016 | — | — | — | — | 1 | 1 |
Show 21 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methamphetamine |
| INN | metamfetamine |
| Description | Methamphetamine[note 1] (contracted from N-methylamphetamine) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine.[note 2] Methamphetamine properly refers to a specific chemical substance, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms, but the hydrochloride salt, commonly called crystal meth, is widely used. Methamphetamine is rarely prescribed over concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy such as Adderall and Vyvanse. Dextromethamphetamine is a stronger CNS stimulant than levomethamphetamine.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN[C@@H](C)Cc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 537-46-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201201 |
| ChEBI ID | 6809 |
| PubChem CID | 1206 |
| DrugBank | DB01577 |
| UNII ID | 44RAL3456C (ChemIDplus, GSRS) |
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Estimated US medical usage
Methamphetamine
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Trends
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Safety
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10,204 adverse events reported
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