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AboutPricing
Drug ReportsMethadone
Methadone
Methadone, Methadose (methadone) is a small molecule pharmaceutical. Methadone was first approved as Dolophine hydrochloride on 1982-01-01. It is used to treat intractable pain and opioid-related disorders in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target kappa-type opioid receptor and delta-type opioid receptor.
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Target
Variants
Financial
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Safety
Events Timeline
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1Y
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FDA approval date
EMA approval date
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Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Methadone, Methadose (discontinued: Dolophine, Methadone, Methadose, Westadone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methadone hydrochloride
Tradename
Company
Number
Date
Products
METHADONE HYDROCHLORIDEHikma PharmaceuticalsN-017058 RX1982-01-01
1 products, RLD, RS
METHADONE HYDROCHLORIDEMylanN-021624 RX1982-01-01
1 products, RLD, RS
METHADOSESPECGXN-017116 RX1982-01-01
1 products, RLD, RS
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Labels
FDA
EMA
Brand Name
Status
Last Update
2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w...Biologic Licensing Application2011-03-11
a mold mixture absidia ramosa acrothecium robustum alternaria alternata aspergillus flavus aspergillus fumigatus aspergillus mixture aspergillus ni...Biologic Licensing Application2009-11-17
all physical sunscreen broad spectrum spf 50OTC monograph not final2021-10-15
animi-3unapproved drug other2013-02-06
anticholiumunapproved drug for use in drug shortage2024-11-08
attitude oceanly phyto-sun kit spf 30C2002632024-04-01
attitude oceanly phyto-sun lip balm spf 30 baby roseC2002632024-04-01
attitude oceanly phyto-sun lip balm spf 30 peachy shellC2002632024-04-01
attitude oceanly phyto-sun lip balm spf 30 terracottaC2002632024-04-01
attitude oceanly phyto-sun tinted - spf 15 - broad spectrum sunscreenC2002632025-01-08
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
opioid-related disordersEFO_0005611D009293F11
intractable pain—D010148—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AC: Diphenylpropylamine derivative analgesics
— N02AC52: Methadone, combinations excl. psycholeptics
— N07: Other nervous system drugs in atc
— N07B: Drugs used in addictive disorders
— N07BC: Drugs used in opioid dependence
— N07BC02: Methadone
HCPCS
Code
Description
G2067
Medication assisted treatment, methadone; weekly bundle including dispensing and/or administration, substance use counseling, individual and group therapy, and toxicology testing, if performed (provision of the services by a medicare-enrolled opioid treatment program)
G2078
Take-home supply of methadone; up to 7 additional day supply (provision of the services by a medicare-enrolled opioid treatment program); list separately in addition to code for primary procedure
H0020
Alcohol and/or drug services; methadone administration and/or service (provision of the drug by a licensed program)
J1230
Injection, methadone hcl, up to 10 mg
S0109
Methadone, oral, 5 mg
Clinical
Clinical Trials
557 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Substance withdrawal syndromeD013375EFO_0005800———1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMethadone
INNmethadone
Description
Methadone is a racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction. It has a role as an opioid analgesic, a mu-opioid receptor agonist, a xenobiotic, an environmental contaminant, a NMDA receptor antagonist and a serotonin uptake inhibitor. It contains a levomethadone and a dextromethadone.
Classification
Small molecule
Drug classOpioid
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1
Identifiers
PDB—
CAS-ID76-99-3
RxCUI—
ChEMBL IDCHEMBL651
ChEBI ID6807
PubChem CID4095
DrugBankDB00333
UNII IDUC6VBE7V1Z (ChemIDplus, GSRS)
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
4988
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Q9UN57
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (Q9R1M0)
Alternate
OPRK1
OPRK1
OPRD1
OPRD1
Organism
Homo sapiens
Gene name
OPRK1
Gene synonyms
OPRK
NCBI Gene ID
4986
Protein name
kappa-type opioid receptor
Protein synonyms
kappa opioid receptor, Opiate receptor, kappa-1
Uniprot ID
Q499G4
Mouse ortholog
Oprk1 (18387)
kappa-type opioid receptor (P33534)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Phytonadione – Amphastar Pharmaceuticals
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Estimated US medical usage
Methadone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 67,318 documents
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Safety
Black-box Warning
Black-box warning for: 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w..., A mold mixture absidia ramosa acrothecium robustum alternaria alternata aspergillus flavus aspergillus fumigatus aspergillus mixture aspergillus ni..., Diskets, Methadone, Methadone hydrochloride, Methadone hydrochloride methadose, Methadone hydrochloride methadose dispersible, Methadone hydrocloride, Methadose, Methadose methadose, Methadose methadose sugar-free, Physicians ez use m-pred, Phytonadione, Vitamin k1, Vitamin k1 - phytonadione, Vitamin k1 phytonadione
Adverse Events
Top Adverse Reactions
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51,838 adverse events reported
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