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Drug ReportsMetformin
Glucophage, Avandamet(metformin)
/ Metformin, Actoplus Met, Avandamet, Competact, Ebymect, Efficib, Eucreas, Fortamet, Glumetza, Icandra, Invokamet, Janumet, Jentadueto, Kazano, Komboglyze, Metformin, Metformin /, Prandimet, Qternmet, Qtrilmet, Ristfor, Segluromet, Sitagliptin / Metformin, Synjardy, Trijardy, Velmetia, Vipdomet, Vokanamet, Xigduo, Zituvimet, Zomarist (metformin) is a small molecule pharmaceutical. Metformin was first approved as Glucophage on 1995-03-03. It is used to treat type 2 diabetes mellitus in the USA. It has been approved in Europe to treat type 2 diabetes mellitus. It is known to target multidrug and toxin extrusion protein 1 and multidrug and toxin extrusion protein 2.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Glumetza, Metformin (discontinued: Fortamet, Glucophage, Metformin, Riomet)
Combinations
Actoplus met, Glipizide metformin, Glyburide metformin, Invokamet, Janumet, Jentadueto, Kazano, Linagliptin metformin, Pioglitazone metformin, Saxagliptin metformin, Segluromet, Synjardy, Trijardy, Xigduo, Zituvimet (discontinued: Actoplus met, Avandamet, Empagliflozin metformin, Glipizide metformin, Glucovance, Glyburide metformin, Kombiglyze, Metaglip, Pioglitazone metformin, Prandimet, Qternmet, Repaglinide metformin, Rosiglitazone metformin, Saxagliptin metformin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metformin hydrochloride
Tradename
Company
Number
Date
Products
GLUMETZASantarusN-021748 RX2005-06-03
2 products, RLD, RS
Show 5 discontinued
Metformin hydrochloride
+
Pioglitazone hydrochloride
Tradename
Company
Number
Date
Products
ACTOPLUS METTakedaN-021842 RX2005-08-29
1 products, RLD, RS
Show 2 discontinued
Canagliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
INVOKAMET XRJohnson & JohnsonN-205879 RX2016-09-20
4 products, RLD, RS
INVOKAMETJohnson & JohnsonN-204353 RX2014-08-08
4 products, RLD, RS
Metformin hydrochloride
+
Sitagliptin phosphate
Tradename
Company
Number
Date
Products
JANUMET XRMerck & CoN-202270 RX2012-02-02
3 products, RLD, RS
JANUMETMerck & CoN-022044 RX2007-03-30
2 products, RLD, RS
Linagliptin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
JENTADUETO XRBoehringer IngelheimN-208026 RX2016-05-27
2 products, RLD, RS
JENTADUETOBoehringer IngelheimN-201281 RX2012-01-30
3 products, RLD, RS
Metformin hydrochloride
+
Saxagliptin hydrochloride
Tradename
Company
Number
Date
Products
KOMBIGLYZE XRAstraZenecaN-200678 DISCN2010-11-05
3 products, RLD
Hide discontinued
Dapagliflozin
+
Metformin hydrochloride
+
Saxagliptin hydrochloride
Tradename
Company
Number
Date
Products
QTERNMET XRAstraZenecaN-210874 DISCN2019-05-02
4 products, RLD
Hide discontinued
Empagliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
SYNJARDY XRBoehringer IngelheimN-208658 RX2016-12-09
4 products, RLD, RS
SYNJARDYBoehringer IngelheimN-206111 RX2015-08-26
4 products, RLD, RS
Empagliflozin
+
Linagliptin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
TRIJARDY XRBoehringer IngelheimN-212614 RX2020-01-27
4 products, RLD, RS
Dapagliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
XIGDUO XRAstraZenecaN-205649 RX2014-10-29
5 products, RLD, RS
Metformin hydrochloride
+
Sitagliptin
Tradename
Company
Number
Date
Products
ZITUVIMET XRZydus TherapeuticsN-216778 RX2024-07-18
3 products, RLD, RS
ZITUVIMETZydus TherapeuticsN-216743 RX2023-11-03
2 products, RLD, RS
Metformin hydrochloride
+
Rosiglitazone maleate
Tradename
Company
Number
Date
Products
AVANDAMETSB PharmcoN-021410 DISCN2002-10-10
5 products, RLD
Hide discontinued
Glyburide
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
GLUCOVANCEBristol Myers SquibbN-021178 DISCN2000-07-31
3 products, RLD
Hide discontinued
Alogliptin benzoate
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
KAZANOTakedaN-203414 RX2013-01-25
2 products, RLD, RS
Glipizide
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
METAGLIPBristol Myers SquibbN-021460 DISCN2002-10-21
3 products, RLD
Hide discontinued
Metformin hydrochloride
+
Repaglinide
Tradename
Company
Number
Date
Products
PRANDIMETNovo NordiskN-022386 DISCN2008-06-23
2 products, RLD
Hide discontinued
Ertugliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
SEGLUROMETMerck & CoN-209806 RX2017-12-19
4 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
actoplus metNew Drug Application2025-03-27
alogliptin and metformin hydrochlorideNDA authorized generic2025-04-11
appforminunapproved drug other2011-08-08
appformin-dunapproved drug other2011-08-08
avandametNew Drug Application2012-08-30
dapagliflozin and metformin hydrochlorideNDA authorized generic2024-12-20
fortametNew Drug Application2010-03-15
glipizide and metformin hydrochlorideANDA2018-12-11
glipizide and metformin hydrochloride glipizide and metformin hydrochlorideANDA2024-12-04
glipizide and metformin hclANDA2025-05-22
Show 41 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
type 2 diabetes mellitusEFO_0001360D003924E11
Agency Specific
FDA
EMA
Expiration
Code
EMPAGLIFLOZIN / METFORMIN HYDROCHLORIDE, SYNJARDY, BOEHRINGER INGELHEIM
2026-12-20PED
2026-06-20NPP
EMPAGLIFLOZIN / METFORMIN HYDROCHLORIDE, SYNJARDY XR, BOEHRINGER INGELHEIM
2026-12-20PED
2026-06-20M-296
LINAGLIPTIN / METFORMIN HYDROCHLORIDE, JENTADUETO, BOEHRINGER INGELHEIM
2026-12-20PED
2026-06-20M-295
2023-03-30M-252
LINAGLIPTIN / METFORMIN HYDROCHLORIDE, JENTADUETO XR, BOEHRINGER INGELHEIM
2026-12-20PED
2026-06-20M-295
2023-03-30M-252
ERTUGLIFLOZIN / METFORMIN HYDROCHLORIDE, SEGLUROMET, MSD SUB MERCK
2024-09-17M-275
METFORMIN HYDROCHLORIDE / SITAGLIPTIN PHOSPHATE, JANUMET, MSD SUB MERCK
2024-06-04PED
2023-12-04M-187
2023-02-12PED
METFORMIN HYDROCHLORIDE / SITAGLIPTIN PHOSPHATE, JANUMET XR, MERCK SHARP DOHME
2024-06-04PED
2023-12-04M-187
2023-02-12PED
Patent Expiration
Patent
Expires
Flag
FDA Information
Metformin Hydrochloride, Riomet Er, Sun Pharm
99623362035-05-01DP
Empagliflozin / Linagliptin / Metformin Hydrochloride, Trijardy Xr, Boehringer Ingelheim
99499982034-06-11U-2290, U-2731
102586372034-04-03U-2290, U-2731
110903232034-04-03U-3192, U-3193
105961202032-03-07DPU-2775, U-2776, U-2790, U-2792
115648862032-03-07DPU-3531
104061722030-06-15DPU-2733
91557052030-05-21DP
85519572029-10-14DPU-2730
94150162029-04-02DP
100223792029-04-02U-2339, U-2732
75794492028-08-01DP
77139382027-04-15DS, DP
88838052025-11-26DP
74079552025-05-02DS, DP
81196482023-08-12U-802, U-1652
81785412023-08-12DPU-775, U-1652, U-1853
Empagliflozin / Metformin Hydrochloride, Synjardy, Boehringer Ingelheim
99499972034-05-17U-3532, U-3533
106104892030-09-30DP
Linagliptin / Metformin Hydrochloride, Jentadueto Xr, Boehringer Ingelheim
95550012033-03-06DPU-1967, U-1968
91738592027-05-04DPU-1503
Dapagliflozin / Metformin Hydrochloride, Xigduo Xr, Astrazeneca Ab
96160282030-11-12DP
86859342030-05-26U-1522
79195982029-12-16DP
85016982027-06-20DPU-493
65151172025-10-04DS, DPU-493
Ertugliflozin / Metformin Hydrochloride, Segluromet, Msd Sub Merck
93082042030-10-21DP
94399022030-10-21U-2214
80805802030-07-13DS, DPU-2214
Canagliflozin / Metformin Hydrochloride, Invokamet, Janssen Pharms
115768942030-07-06DP
79435822029-02-26DS, DPU-493, U-2441, U-2632
85132022027-12-03DS, DPU-493, U-2441, U-2632
79437882027-07-14DS, DP
82222192025-04-11U-493, U-2441, U-2632
87854032024-07-30DP
Linagliptin / Metformin Hydrochloride, Jentadueto, Boehringer Ingelheim
88466952030-06-04U-1503
109738272029-04-02DP
86739272027-05-04U-1503
Alogliptin Benzoate / Metformin Hydrochloride, Kazano, Takeda Pharms Usa
89006382029-05-24DP
78076892028-06-27DS, DPU-1337
82885392025-06-24DP
81736632025-03-15U-1338
Metformin Hydrochloride / Pioglitazone Hydrochloride, Actoplus Met, Takeda Pharms Usa
93207142029-02-03DP
91016602027-01-22DP
Show 5 more
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BA: Biguanide blood glucose lower drugs
— A10BA02: Metformin
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD02: Metformin and sulfonylureas
— A10BD03: Metformin and rosiglitazone
— A10BD05: Metformin and pioglitazone
— A10BD07: Metformin and sitagliptin
— A10BD08: Metformin and vildagliptin
— A10BD10: Metformin and saxagliptin
— A10BD11: Metformin and linagliptin
— A10BD13: Metformin and alogliptin
— A10BD14: Metformin and repaglinide
— A10BD15: Metformin and dapagliflozin
— A10BD16: Metformin and canagliflozin
— A10BD17: Metformin and acarbose
— A10BD18: Metformin and gemigliptin
— A10BD20: Metformin and empagliflozin
— A10BD22: Metformin and evogliptin
— A10BD23: Metformin and ertugliflozin
— A10BD25: Metformin, saxagliptin and dapagliflozin
— A10BD26: Metformin and lobeglitazone
— A10BD27: Metformin, linagliptin and empagliflozin
HCPCS
No data
Clinical
Clinical Trials
2944 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———9————9
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMetformin
INNmetformin
Description
Metformin is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. It has a role as a hypoglycemic agent, a xenobiotic, an environmental contaminant and a geroprotector. It is functionally related to a biguanide. It is a conjugate base of a metformin(1+).
Classification
Small molecule
Drug classhypoglycemics (phenformin type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)C(=N)NC(=N)N
Identifiers
PDB—
CAS-ID657-24-9
RxCUI—
ChEMBL IDCHEMBL1431
ChEBI ID6801
PubChem CID4091
DrugBankDB00331
UNII ID9100L32L2N (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SLC47A1
SLC47A1
SLC47A2
SLC47A2
Organism
Homo sapiens
Gene name
SLC47A1
Gene synonyms
MATE1
NCBI Gene ID
55244
Protein name
multidrug and toxin extrusion protein 1
Protein synonyms
hMATE-1, MATE-1, multidrug and toxin extrusion 1, solute carrier family 47 (multidrug and toxin extrusion), member 1, Solute carrier family 47 member 1
Uniprot ID
Q9NVA3
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Metformin – Amneal Pharmaceuticals
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Janumet – Merck & Co
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Estimated US medical usage
Metformin
+
Empagliflozin
Total medical expenditures per year (USD, in millions)
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Metformin
+
Glipizide
Total medical expenditures per year (USD, in millions)
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Metformin
+
Glyburide
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Metformin
+
Linagliptin
Total medical expenditures per year (USD, in millions)
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Metformin
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Metformin
+
Pioglitazone
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Metformin
+
Rosiglitazone
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Metformin
+
Saxagliptin
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Metformin
+
Sitagliptin
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 36,958 documents
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Safety
Black-box Warning
Black-box warning for: Actoplus met, Alogliptin and metformin hydrochloride, Appformin, Appformin-d, Avandamet, Dapagliflozin and metformin hydrochloride, Fortamet, Glumetza, Glyburide and metformin hydrochloride, Glyburide-metformin hydrochloride, Invokamet, Invokamet invokamet xr, Janumet, Jentadueto, Jentadueto xr, Kazano, Kombiglyze, Metformin, Metformin er 500 mg metformin er 750 mg, Metformin hydrochloride, Metformin hydrochloride extended-release, Metformin hydrochloride metformin hydrochloride, Metformin hydrochloride oral solution, Pioglitazole and metformin hydrochloride, Pioglitazone and metformin, Pioglitazone hcl and metformin hcl, Pioglitazone hydrochloride and metformin hydrochloride, Saxagliptin and metformin, Saxagliptin and metformin hydrochloride, Segluromet, Sitagliptin and metformin hydrochloride, Synjardy, Synjardy synjardy, Trijardy xr, Xigduo, Zituvimet, Zituvimet xr
Adverse Events
Top Adverse Reactions
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135,637 adverse events reported
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