Metergoline
Metergoline is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1D, and 5-hydroxytryptamine receptor 1E.
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Clinical Trials
68 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | 1 | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | 1 | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | 1 | — | 1 |
| Hiv-2 | D015498 | — | — | — | — | — | 1 | — | 1 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia | D007951 | — | C92 | 5 | 6 | 5 | — | 1 | 15 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 5 | 5 | — | 1 | 13 |
| Leukemia | D007938 | — | C95 | 5 | 4 | 4 | — | — | 12 |
| Stomach diseases | D013272 | — | — | — | — | 1 | — | 3 | 4 |
| Recurrence | D012008 | — | — | — | — | 1 | — | 1 | 2 |
| Coronary disease | D003327 | — | — | — | — | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 1 | — | — | 1 |
| Stomach ulcer | D013276 | — | K25 | — | — | 1 | — | — | 1 |
| Gastritis | D005756 | EFO_0000217 | K29.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | — | — | 1 | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | — | 1 | — | — | — | 1 |
| Monocytic leukemia acute | D007948 | — | — | — | 1 | — | — | — | 1 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | — | 1 | — | — | — | 1 |
| Erythroblastic leukemia acute | D004915 | EFO_1001257 | C94.0 | — | 1 | — | — | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | — | — | — | 1 |
| Anterior wall myocardial infarction | D056988 | EFO_1000812 | — | — | 1 | — | — | — | 1 |
| Infarction | D007238 | EFO_0009463 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | — | 1 |
| Ischemia | D007511 | EFO_0000556 | — | 1 | — | — | — | — | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Capsule endoscopy | D053704 | — | — | — | — | — | — | 8 | 8 |
| Low back pain | D017116 | — | M54.5 | — | — | — | — | 4 | 4 |
| Back pain | D001416 | — | M54 | — | — | — | — | 4 | 4 |
| Gastrointestinal diseases | D005767 | — | — | — | — | — | — | 3 | 3 |
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | — | — | — | — | 3 | 3 |
| Intestinal diseases | D007410 | — | K63.9 | — | — | — | — | 3 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 2 | 2 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Metergoline |
| INN | metergoline |
| Description | Metergoline is an ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7. It has a role as a serotonergic antagonist, a dopamine agonist and a geroprotector. It is an ergoline alkaloid and a carbamate ester. |
| Classification | Small molecule |
| Drug class | ergot alkaloid deriviatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 17692-51-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19215 |
| ChEBI ID | 64216 |
| PubChem CID | 28693 |
| DrugBank | — |
| UNII ID | 1501393LY5 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
HTR7
HTR7
HTR5A
HTR5A
HTR1F
HTR1F
HTR2A
HTR2A
HTR6
HTR6
HTR2B
HTR2B
HTR1B
HTR1B
HTR2C
HTR2C
HTR1D
HTR1D
HTR1E
HTR1E
Variants
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Trends
PubMed Central
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Safety
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Adverse Events
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1,336 adverse events reported
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