Metergoline
Metergoline is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1D, and 5-hydroxytryptamine receptor 1E.
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69 clinical trials
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Indications Phases 4
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 1 | 1 |
| Hyperglycemia | D006943 | — | R73.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Metergoline |
| INN | metergoline |
| Description | Metergoline is an ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7. It has a role as a serotonergic antagonist, a dopamine agonist and a geroprotector. It is an ergoline alkaloid and a carbamate ester. |
| Classification | Small molecule |
| Drug class | ergot alkaloid deriviatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 17692-51-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19215 |
| ChEBI ID | 64216 |
| PubChem CID | 28693 |
| DrugBank | — |
| UNII ID | 1501393LY5 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
HTR7
HTR7
HTR5A
HTR5A
HTR1F
HTR1F
HTR2A
HTR2A
HTR6
HTR6
HTR2B
HTR2B
HTR1B
HTR1B
HTR2C
HTR2C
HTR1D
HTR1D
HTR1E
HTR1E
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Safety
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1,334 adverse events reported
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