Metergoline
Metergoline is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1D, and 5-hydroxytryptamine receptor 1E.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
67 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | 1 | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | 1 | — | 1 |
| Hiv-2 | D015498 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 5 | 4 | — | — | 11 |
| Myeloid leukemia | D007951 | — | C92 | 5 | 5 | 1 | — | — | 10 |
| Leukemia | D007938 | — | C95 | 5 | 3 | 1 | — | — | 8 |
| Stomach diseases | D013272 | — | — | — | — | 1 | — | 3 | 4 |
| Recurrence | D012008 | — | — | — | — | 1 | — | 1 | 2 |
| Febrile neutropenia | D064147 | — | — | — | 1 | 1 | — | — | 1 |
| Coronary disease | D003327 | — | — | — | — | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 1 | — | — | 1 |
| Stomach ulcer | D013276 | — | K25 | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | — | — | 1 | 2 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | 1 | — | — | — | 1 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | — | 1 | — | — | — | 1 |
| Monocytic leukemia acute | D007948 | — | — | — | 1 | — | — | — | 1 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | — | 1 | — | — | — | 1 |
| Erythroblastic leukemia acute | D004915 | EFO_1001257 | C94.0 | — | 1 | — | — | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | — | — | — | 1 |
| Anterior wall myocardial infarction | D056988 | EFO_1000812 | — | — | 1 | — | — | — | 1 |
| Infarction | D007238 | EFO_0009463 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking | D012907 | EFO_0004318 | — | 1 | — | — | — | — | 1 |
| Ischemia | D007511 | EFO_0000556 | — | 1 | — | — | — | — | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Capsule endoscopy | D053704 | — | — | — | — | — | — | 8 | 8 |
| Low back pain | D017116 | — | M54.5 | — | — | — | — | 4 | 4 |
| Gastrointestinal diseases | D005767 | — | — | — | — | — | — | 3 | 3 |
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | — | — | — | — | 3 | 3 |
| Intestinal diseases | D007410 | — | K63.9 | — | — | — | — | 3 | 3 |
| Back pain | D001416 | — | M54 | — | — | — | — | 3 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 2 | 2 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 2 | 2 |
Show 50 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Metergoline |
| INN | metergoline |
| Description | Metergoline is an ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7. It has a role as a serotonergic antagonist, a dopamine agonist and a geroprotector. It is an ergoline alkaloid and a carbamate ester. |
| Classification | Small molecule |
| Drug class | ergot alkaloid deriviatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 17692-51-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19215 |
| ChEBI ID | 64216 |
| PubChem CID | 28693 |
| DrugBank | — |
| UNII ID | 1501393LY5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HTR7
HTR7
HTR5A
HTR5A
HTR1F
HTR1F
HTR2A
HTR2A
HTR6
HTR6
HTR2B
HTR2B
HTR1B
HTR1B
HTR2C
HTR2C
HTR1D
HTR1D
HTR1E
HTR1E
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 23,055 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
1,348 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use