Metaproterenol
Metaproterenol (metaproterenol) is a small molecule pharmaceutical. Metaproterenol was first approved as Alupent on 1982-01-01. It is used to treat asthma, bronchial spasm, chronic bronchitis, and pulmonary emphysema in the USA. The pharmaceutical is active against beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Metaproterenol (discontinued: Alupent, Metaproterenol, Prometa)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metaproterenol sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ALUPENT | Boehringer Ingelheim | N-015874 DISCN | 1982-01-01 | 2 products |
| ALUPENT | Boehringer Ingelheim | N-016402 DISCN | 1982-01-01 | 1 products |
| ALUPENT | Boehringer Ingelheim | N-017571 DISCN | 1982-01-01 | 1 products |
| ALUPENT | Boehringer Ingelheim | N-017659 DISCN | 1982-01-01 | 1 products |
| ALUPENT | Boehringer Ingelheim | N-018761 DISCN | 1983-06-30 | 2 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| prenatryl | unapproved drug other | 2021-02-19 |
| prenatryl prometa | unapproved drug other | 2024-10-08 |
| prometa | unapproved drug other | 2021-02-23 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| chronic bronchitis | — | D029481 | J42 |
| asthma | EFO_0000270 | D001249 | J45 |
| pulmonary emphysema | — | D011656 | J43 |
| bronchial spasm | — | D001986 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03A: Adrenergics, inhalants
— R03AB: Non-selective beta-adrenoreceptor agonist inhalants
— R03AB03: Orciprenaline
— R03C: Adrenergics for systemic use
— R03CB: Non-selective beta-adrenoreceptor agonists for systemic use
— R03CB03: Orciprenaline
— R03CB53: Orciprenaline, combinations
HCPCS
Code | Description |
|---|---|
| J7667 | Metaproterenol sulfate, inhalation solution, compounded product, concentrated form, per 10 milligrams |
| J7668 | Metaproterenol sulfate, inhalation solution, fda-approved final product, non-compounded, administered through dme, concentrated form, per 10 milligrams |
| J7669 | Metaproterenol sulfate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 10 milligrams |
| J7670 | Metaproterenol sulfate, inhalation solution, compounded product, administered through dme, unit dose form, per 10 milligrams |
Clinical
No data
Drug
General
| Drug common name | Metaproterenol |
| INN | orciprenaline |
| Description | Metaproterenol is a member of phenylethanolamines. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)NCC(O)c1cc(O)cc(O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 586-06-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL776 |
| ChEBI ID | 6792 |
| PubChem CID | 4086 |
| DrugBank | DB00816 |
| UNII ID | 53QOG569E0 (ChemIDplus, GSRS) |
Target
Agency Approved
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Alternate
No data
Variants
No data
Financial
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Estimated US medical usage
Metaproterenol
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
No data
Safety
Black-box Warning
Black-box warning for: Prenatryl, Prenatryl prometa, Prometa
Adverse Events
0 adverse events reported
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