Mestranol
Enovid, Norethin 1/50m, Norinyl, Ortho-novum, Ovulen (mestranol) is a small molecule pharmaceutical. Mestranol was first approved as Ovulen on 1982-01-01.
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Mestranol
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Norethindrone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NORINYL 1+50 21-DAY | Allergan | N-013625 DISCN | 1982-01-01 | 1 products |
| NORINYL | Allergan | N-013625 DISCN | 1982-01-01 | 1 products |
| NORINYL 1+50 28-DAY | Allergan | N-016659 DISCN | 1982-01-01 | 1 products, RLD |
| NORINYL 1+80 21-DAY | G.D. Searle | N-016724 DISCN | 1982-01-01 | 1 products |
| NORINYL 1+80 28-DAY | G.D. Searle | N-016725 DISCN | 1982-01-01 | 1 products |
| ORTHO-NOVUM 1/50 28 | Johnson & Johnson | N-016709 DISCN | 1982-01-01 | 1 products |
| ORTHO-NOVUM 10-21 | Johnson & Johnson | N-012728 DISCN | 1982-01-01 | 1 products |
| ORTHO-NOVUM 1/50 21 | Johnson & Johnson | N-012728 DISCN | 1982-01-01 | 1 products |
| ORTHO-NOVUM 2-21 | Johnson & Johnson | N-012728 DISCN | 1982-01-01 | 1 products |
| ORTHO-NOVUM 1/80 21 | Johnson & Johnson | N-016715 DISCN | 1982-01-01 | 1 products |
| ORTHO-NOVUM 1/80 28 | Johnson & Johnson | N-016715 DISCN | 1982-01-01 | 1 products |
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Mestranol
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Norethynodrel
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ENOVID | G.D. Searle | N-010976 DISCN | 1982-01-01 | 2 products |
| ENOVID-E | G.D. Searle | N-010976 DISCN | 1982-01-01 | 1 products |
| ENOVID-E 21 | G.D. Searle | N-010976 DISCN | 1982-01-01 | 1 products |
| ENOVID | G.D. Searle | N-010976 DISCN | 1982-01-01 | 1 products |
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Ethynodiol diacetate
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Mestranol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| OVULEN | G.D. Searle | N-016029 DISCN | 1982-01-01 | 1 products |
| OVULEN-21 | G.D. Searle | N-016029 DISCN | 1982-01-01 | 1 products |
| OVULEN-28 | G.D. Searle | N-016705 DISCN | 1982-01-01 | 1 products |
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50 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometriosis | D004715 | EFO_0001065 | N80 | — | — | — | 1 | 1 | 2 |
| Pelvic pain | D017699 | — | — | — | — | — | 1 | 1 | 2 |
| Dysmenorrhea | D004412 | HP_0100607 | N94.6 | — | — | 1 | 1 | — | 2 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | 1 | — | 1 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | — | — | — | 1 | — | 1 |
| Premature menopause | D008594 | HP_0008209 | E28.31 | — | — | — | 1 | — | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | 1 | — | 1 |
| Chronic pain | D059350 | HP_0012532 | — | — | — | — | 1 | — | 1 |
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | — | — | — | 1 | — | 1 |
| Visceral pain | D059265 | — | — | — | — | — | 1 | — | 1 |
Show 1 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 9 | — | 2 | — | 1 | 12 |
| Contraception | D003267 | — | — | — | — | 4 | — | — | 4 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 2 | — | 1 | — | — | 3 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | 1 | — | — | 2 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | 1 | — | 1 | — | — | 2 |
| Ovulation | D010060 | — | — | — | — | 1 | — | — | 1 |
| Covid-19 | D000086382 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 1 | — | — | 1 | 5 |
| Hyperandrogenism | D017588 | — | — | — | 2 | — | — | — | 2 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | 1 | — | — | — | 1 |
| Insulin resistance | D007333 | HP_0000855 | — | — | 1 | — | — | — | 1 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | — | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | 1 | — | — | — | — | 1 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | — | — | — | — | 1 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | 1 | — | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pituitary diseases | D010900 | — | E23.7 | — | — | — | — | 1 | 1 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | — | 1 | 1 |
| Thrombosis | D013927 | — | — | — | — | — | — | 1 | 1 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | — | — | — | 1 | 1 |
| Pulmonary embolism | D011655 | HP_0002204 | I26 | — | — | — | — | 1 | 1 |
| Embolism | D004617 | — | — | — | — | — | — | 1 | 1 |
| Intracranial thrombosis | D020767 | — | — | — | — | — | — | 1 | 1 |
| Thromboembolism | D013923 | HP_0001907 | — | — | — | — | — | 1 | 1 |
| Intracranial sinus thrombosis | D012851 | — | — | — | — | — | — | 1 | 1 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mestranol |
| INN | mestranol |
| Description | Mestranol is a terminal acetylenic compound that is (17alpha)-17-ethynylestra-1(10),2,4-triene substituted by a methoxy group at position 3 and a hydroxy group at position 17. It has a role as a prodrug and a xenoestrogen. It is a 17beta-hydroxy steroid, a terminal acetylenic compound and an aromatic ether. It is functionally related to a 17beta-estradiol. |
| Classification | Small molecule |
| Drug class | estrogens |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(OC)ccc4[C@H]3CC[C@@]21C |
Identifiers
| PDB | — |
| CAS-ID | 72-33-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201151 |
| ChEBI ID | 6784 |
| PubChem CID | 6291 |
| DrugBank | DB01357 |
| UNII ID | B2V233XGE7 (ChemIDplus, GSRS) |
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Mestranol
+
Norethindrone
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Safety
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357 adverse events reported
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