Merrem iv, Vaborem(meropenem)
Meropenem, Merrem, Vabomere, Vaborem (meropenem) is a small molecule pharmaceutical. Meropenem was first approved as Merrem iv on 1996-06-21. It is used to treat appendicitis, bacterial infections, bacteroides infections, escherichia coli infections, and fever amongst others in the USA. It has been approved in Europe to treat bacteremia, bacterial infections, pneumonia, respiratory tract infections, and urinary tract infections amongst others.
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Commercial
Trade Name
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Meropenem (discontinued: Meropenem, Merrem)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meropenem
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MEROPENEM AND SODIUM CHLORIDE IN DUPLEX CONTAINER | B. Braun Medical | N-202106 RX | 2015-04-30 | 2 products |
| MEROPENEM | HQ Specialty Pharma | N-215212 RX | 2023-07-26 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| meropenem | ANDA | 2025-09-16 |
| meropenem and sodium chloride | New Drug Application | 2025-08-05 |
| meropenem meropenem | ANDA | 2019-05-24 |
| vabomere | New Drug Application | 2025-03-25 |
Indications
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EMA
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
MEROPENEM / VABORBACTAM, VABOMERE, REMPEX | |||
| 2027-08-29 | GAIN | ||
| 2022-08-29 | NCE | ||
Clinical
Clinical Trials
251 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | 9 | 13 | 13 | 18 | 53 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | 2 | 7 | 10 | 11 | 17 | 40 |
| Communicable diseases | D003141 | — | — | — | 5 | 10 | 7 | 8 | 30 |
| Pneumonia | D011014 | EFO_0003106 | J18 | 1 | 2 | 11 | 7 | 7 | 28 |
| Bacterial infections | D001424 | — | A49 | 5 | 1 | 3 | 8 | 6 | 22 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | 1 | 3 | 12 | 2 | 2 | 20 |
| Intraabdominal infections | D059413 | — | — | 1 | 7 | 11 | 1 | — | 18 |
| Critical illness | D016638 | — | — | — | 1 | — | 4 | 11 | 16 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | 4 | 4 | 7 | 15 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | 2 | 10 | 2 | 1 | 14 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | — | 1 | 1 | — | 7 | 8 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | 3 | 3 | — | 1 | 5 |
| Cross infection | D003428 | — | — | — | 2 | 1 | — | 2 | 4 |
| Appendicitis | D001064 | EFO_0007149 | K37 | — | 1 | 3 | — | 1 | 4 |
| Shock | D012769 | — | R57.1 | 1 | 1 | 1 | — | 1 | 3 |
| Abscess | D000038 | EFO_0003030 | — | — | 1 | 2 | — | — | 3 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | 1 | — | 1 | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | 1 | — | 1 | 2 |
| Neonatal sepsis | D000071074 | — | — | — | — | 1 | — | 1 | 2 |
| Iatrogenic disease | D007049 | — | — | — | 1 | 1 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | 3 | — | — | — | 3 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | — | — | — | 2 |
| Meningitis | D008581 | EFO_0000584 | G03 | 1 | 1 | — | — | 1 | 2 |
| Melioidosis | D008554 | — | A24.9 | — | 1 | — | — | 1 | 2 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | — | 1 | — | — | — | 1 |
| Respiratory insufficiency | D012131 | — | J96.9 | 1 | 1 | — | — | — | 1 |
| Necrotizing enterocolitis | D020345 | EFO_0003928 | K55.3 | 1 | 1 | — | — | — | 1 |
| Burns | D002056 | — | T30.0 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | — | N19 | 2 | — | — | — | 3 | 5 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | 1 | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | — | — | — | — | 1 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute kidney injury | D058186 | — | N17 | — | — | — | — | 4 | 4 |
| Drug monitoring | D016903 | — | — | — | — | — | — | 3 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 2 | 2 |
| Enterococcus | D016983 | — | — | — | — | — | — | 2 | 2 |
| Renal replacement therapy | D017582 | — | — | — | — | — | — | 2 | 2 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | — | — | — | — | 2 | 2 |
| Liver failure | D017093 | — | K72.9 | — | — | — | — | 2 | 2 |
| Acute-on-chronic liver failure | D065290 | — | — | — | — | — | — | 2 | 2 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Meropenem |
| INN | meropenem |
| Description | Meropenem is a carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively. It has a role as an antibacterial drug, an antibacterial agent and a drug allergen. It is a carbapenemcarboxylic acid, a pyrrolidinecarboxamide, an alpha,beta-unsaturated monocarboxylic acid and an organic sulfide. |
| Classification | Small molecule |
| Drug class | antibacterial antibiotics, carbapenem derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)N(C)C)C3)[C@H](C)[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 96036-03-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL127 |
| ChEBI ID | 43968 |
| PubChem CID | 441130 |
| DrugBank | DB00760 |
| UNII ID | YOP6PX0BAO (ChemIDplus, GSRS) |
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Merrem – AstraZeneca
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Meropenem
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16,828 adverse events reported
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