Merrem, Vaborem(meropenem)
Meropenem, Merrem, Vabomere, Vaborem (meropenem) is a small molecule pharmaceutical. Meropenem was first approved as Merrem on 1996-06-21. It is used to treat appendicitis, bacterial infections, bacteroides infections, escherichia coli infections, and fever amongst others in the USA. It has been approved in Europe to treat bacteremia, bacterial infections, pneumonia, respiratory tract infections, and urinary tract infections amongst others.
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Commercial
Trade Name
FDA
EMA
Merrem (generic drugs available since 2011-10-26)
CombinationsVabomere
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meropenem
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MEROPENEM AND SODIUM CHLORIDE IN DUPLEX CONTAINER | B. Braun Medical | N-202106 RX | 2015-04-30 | 2 products |
| MEROPENEM | HQ Specialty Pharma | N-215212 RX | 2023-07-26 | 1 products, RLD, RS |
| MERREM | Mylan | N-050706 RX | 1996-06-21 | 2 products, RLD, RS |
Meropenem
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Vaborbactam
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VABOMERE | REMPEX | N-209776 RX | 2017-08-29 | 1 products, RLD, RS |
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Indications
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EMA
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
MEROPENEM / VABORBACTAM, VABOMERE, REMPEX | |||
| 2027-08-29 | GAIN | ||
| 2022-08-29 | NCE | ||
Clinical
Clinical Trials
223 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | 1 | 4 | 6 | 5 | 11 | 23 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | 1 | 2 | 11 | 2 | 1 | 17 |
| Infections | D007239 | EFO_0000544 | — | 1 | 2 | 3 | 3 | 6 | 14 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 1 | 4 | 2 | 6 | 13 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | 1 | 10 | 2 | 1 | 13 |
| Bacterial infections | D001424 | — | A49 | 5 | 1 | 1 | 3 | 4 | 13 |
| Intraabdominal infections | D059413 | — | — | 1 | 5 | 6 | 1 | — | 12 |
| Septic shock | D012772 | — | A48.3 | 3 | 3 | 3 | 2 | 4 | 12 |
| Critical illness | D016638 | — | — | — | 1 | — | 1 | 9 | 11 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | 2 | 8 | 1 | — | 11 |
Show 24 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | 2 | — | 1 | 3 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | 1 | — | 1 | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | 1 | — | 1 | 2 |
| Neonatal sepsis | D000071074 | HP_0040187 | — | — | — | 1 | — | 1 | 2 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 1 | 1 | — | — | 2 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | 1 | — | 1 | 2 |
| Ascites | D001201 | HP_0001541 | R18 | — | 1 | 1 | — | — | 1 |
| Iatrogenic disease | D007049 | — | — | — | — | 1 | — | — | 1 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | — | 1 | — | — | 1 |
| Abscess | D000038 | EFO_0003030 | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | 3 | — | — | — | 3 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | — | — | — | 2 |
| Melioidosis | D008554 | — | A24.9 | — | 1 | — | — | 1 | 2 |
| Cross infection | D003428 | — | — | — | 1 | — | — | 1 | 2 |
| Communicable diseases | D003141 | — | — | — | 1 | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | — | 1 | — | — | — | 1 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 1 | — | — | — | 1 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | 1 | 1 | — | — | — | 1 |
| Meningitis | D008581 | HP_0001287 | G03 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | — | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | — | — | — | — | 6 | 6 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 4 | 4 |
| Drug monitoring | D016903 | — | — | — | — | — | — | 3 | 3 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 2 | 2 |
| Renal replacement therapy | D017582 | — | — | — | — | — | — | 2 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
Show 36 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Meropenem |
| INN | meropenem |
| Description | Meropenem is a carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively. It has a role as an antibacterial drug, an antibacterial agent and a drug allergen. It is a carbapenemcarboxylic acid, a pyrrolidinecarboxamide, an alpha,beta-unsaturated monocarboxylic acid and an organic sulfide. |
| Classification | Small molecule |
| Drug class | antibacterial antibiotics, carbapenem derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)N(C)C)C3)[C@H](C)[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 96036-03-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL127 |
| ChEBI ID | 43968 |
| PubChem CID | 441130 |
| DrugBank | DB00760 |
| UNII ID | YOP6PX0BAO (ChemIDplus, GSRS) |
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Merrem – AstraZeneca
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Meropenem
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Safety
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10,577 adverse events reported
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