Purinethol, Xaluprine (previously mercaptopurine nova laboratories)(mercaptopurine)
Mercaptopurine, Purinethol, Purixan, Xaluprine (mercaptopurine) is a small molecule pharmaceutical. Mercaptopurine was first approved as Purinethol on 1982-01-01. It is used to treat b-cell chronic lymphocytic leukemia, non-hodgkin lymphoma, and precursor cell lymphoblastic leukemia-lymphoma in the USA. It has been approved in Europe to treat lymphoid leukemia.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Mercaptopurine, Purinethol, Purixan
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mercaptopurine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PURIXAN | Nova Laboratories | N-205919 RX | 2014-04-28 | 1 products, RLD, RS |
| PURINETHOL | Stason Pharmaceuticals | N-009053 RX | 1982-01-01 | 1 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| mercaptopurine | ANDA | 2025-02-21 |
| purixan | New Drug Application | 2024-10-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| non-hodgkin lymphoma | — | D008228 | C85.9 |
| precursor cell lymphoblastic leukemia-lymphoma | — | D054198 | C91.0 |
| b-cell chronic lymphocytic leukemia | — | D015451 | C91.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| S0108 | Mercaptopurine, oral, 50 mg |
Clinical
Clinical Trials
268 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mercaptopurine |
| INN | mercaptopurine |
| Description | Purine-6-thiol is a thiol that is the tautomer of mercaptopurine. It has a role as an antineoplastic agent and an antimetabolite. It is a tautomer of a mercaptopurine. It derives from a hydride of a 7H-purine. |
| Classification | Small molecule |
| Drug class | aptamers, classical and mirror |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O.S=c1[nH]cnc2nc[nH]c12 |
Identifiers
| PDB | — |
| CAS-ID | 6112-76-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200751 |
| ChEBI ID | 31822 |
| PubChem CID | 667490 |
| DrugBank | DB01033 |
| UNII ID | PKK6MUZ20G (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Mercaptopurine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14,929 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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13,841 adverse events reported
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