Nucala(mepolizumab)
Nucala (mepolizumab) is an antibody pharmaceutical. Mepolizumab was first approved as Nucala on 2015-11-04. It is used to treat asthma in the USA. It has been approved in Europe to treat asthma. The pharmaceutical is active against interleukin-5.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| respiratory tract diseases | D012140 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Nucala
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nucala | Biologic Licensing Application | 2023-03-08 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| asthma | EFO_0000270 | D001249 | J45 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
mepolizumab, Nucala, GlaxoSmithKline LLC | |||
| 2027-09-25 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2182 | Injection, mepolizumab, 1 mg |
Clinical
Clinical Trials
133 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | 2 | 5 | 15 | 13 | 42 | 77 |
| Pulmonary eosinophilia | D011657 | EFO_0007257 | J82.81 | — | — | 3 | 6 | 20 | 29 |
| Nasal polyps | D009298 | — | J33 | 1 | 1 | 2 | 8 | 10 | 22 |
| Rhinosinusitis | D000096825 | — | — | 1 | — | 1 | 8 | 10 | 20 |
| Eosinophilia | D004802 | — | D72.1 | 1 | 2 | 2 | 3 | 8 | 15 |
| Polyps | D011127 | EFO_0000662 | — | — | — | 2 | 1 | 4 | 7 |
| Sinusitis | D012852 | EFO_0007486 | J32 | 1 | — | — | 3 | 3 | 7 |
| Inflammation | D007249 | MP_0001845 | — | — | — | 1 | 2 | 1 | 4 |
| Bronchitis | D001991 | — | J40 | — | — | 1 | 1 | — | 2 |
| Aspirin-induced asthma | D055963 | — | — | — | — | — | 1 | — | 1 |
Show 3 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Churg-strauss syndrome | D015267 | EFO_0007208 | M30.1 | 2 | 3 | 5 | — | 4 | 12 |
| Syndrome | D013577 | — | — | 2 | 4 | 5 | — | 1 | 10 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 2 | 6 | — | 2 | 9 |
| Hypereosinophilic syndrome | D017681 | EFO_1001467 | D72.11 | 1 | 2 | 5 | — | 1 | 8 |
| Granulomatosis with polyangiitis | D014890 | EFO_0005297 | M31.3 | 1 | — | 4 | — | 3 | 8 |
| Systemic vasculitis | D056647 | — | — | — | — | 4 | — | 2 | 6 |
| Eosinophilic granuloma | D004803 | — | C96.6 | — | — | 3 | — | 2 | 5 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | 3 | — | 2 | 5 |
| Vasculitis | D014657 | EFO_0006803 | M31 | — | — | 1 | — | — | 1 |
| Virus diseases | D014777 | — | B34 | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | 1 | 4 | — | — | — | 4 |
| Esophagitis | D004941 | HP_0100633 | K20 | 1 | 4 | — | — | — | 4 |
| Angioedema | D000799 | EFO_0005532 | T78.3 | — | 1 | — | — | — | 1 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 1 | — | — | — | 1 |
| Eczema | D004485 | — | L30.9 | — | 1 | — | — | — | 1 |
| Dermatitis | D003872 | — | L30.9 | — | 1 | — | — | — | 1 |
| Bullous pemphigoid | D010391 | EFO_0007187 | L12 | — | 1 | — | — | — | 1 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | 1 | 1 | — | — | — | 1 |
| Coronary disease | D003327 | — | — | — | 1 | — | — | — | 1 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | — | — | — | 1 |
Show 1 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Pharmacological phenomena | D000069437 | — | — | 1 | — | — | — | — | 1 |
| Fasciitis | D005208 | HP_0100537 | M72.9 | 1 | — | — | — | — | 1 |
| Chronic urticaria | D000080223 | — | L50.8 | 1 | — | — | — | — | 1 |
| Urticaria | D014581 | EFO_0005531 | L50 | 1 | — | — | — | — | 1 |
| Hemophagocytic lymphohistiocytosis | D051359 | — | D76.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | — | — | 1 | 1 |
| Psychological stress | D013315 | — | — | — | — | — | — | 1 | 1 |
| Emotions | D004644 | — | — | — | — | — | — | 1 | 1 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 1 | 1 |
| Psychological adaptation | D000223 | — | — | — | — | — | — | 1 | 1 |
| Psychological distress | D000079225 | — | — | — | — | — | — | 1 | 1 |
| Emotional adjustment | D000066498 | — | — | — | — | — | — | 1 | 1 |
| Psychosocial functioning | D000083623 | — | — | — | — | — | — | 1 | 1 |
| Airway remodeling | D056151 | — | — | — | — | — | — | 1 | 1 |
Show 3 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Mepolizumab |
| INN | mepolizumab |
| Description | Mepolizumab, sold under the brand name Nucala, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis, and hypereosinophilic syndrome (HES). It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108429 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB06612 |
| UNII ID | 90Z2UF0E52 (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 5,309 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
39,394 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use