Menatetrenone
Menatetrenone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
162 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 2 | 2 | 10 | 14 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | — | — | 1 | 1 | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | — | 1 | 3 |
| Rheumatic heart disease | D012214 | EFO_1001161 | I09.9 | — | — | 1 | — | — | 1 |
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | 1 | — | — | 1 |
| Thromboembolism | D013923 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Venous thrombosis | D020246 | — | I82.40 | 1 | 1 | — | — | 1 | 3 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | 1 | — | — | 1 | 2 |
| Thrombosis | D013927 | — | — | 1 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Embolism | D004617 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 1 | 1 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | — | — | 1 | 1 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 1 | 1 |
| Gastrointestinal hemorrhage | D006471 | — | K92.2 | — | — | — | — | 1 | 1 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Menatetrenone |
| INN | menatetrenone |
| Description | Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent. |
| Classification | Small molecule |
| Drug class | aldosterone antagonists (spironolactone type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)c2ccccc2C1=O |
Identifiers
| PDB | — |
| CAS-ID | 863-61-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL259223 |
| ChEBI ID | 78277 |
| PubChem CID | 5282367 |
| DrugBank | DB12148 |
| UNII ID | 27Y876D139 (ChemIDplus, GSRS) |
Target
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Trends
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Safety
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Adverse Events
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52 adverse events reported
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