Namenda, Ebixa(memantine)
Axura, Ebixa, Marixino, Maruxa, Memantine, Namenda, Namzaric, Nemdatine (memantine) is a small molecule pharmaceutical. Memantine was first approved as Ebixa on 2002-05-15. It is used to treat alzheimer disease in the USA. It has been approved in Europe to treat alzheimer disease. It is known to target glutamate receptor ionotropic, NMDA 2C.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Namenda (generic drugs available since 2010-04-14)
CombinationsNamzaric (generic drugs available since 2010-04-14)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Donepezil hydrochloride
+
Memantine hydrochloride
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| generic drug | unapproved drug other | 2019-05-07 |
| ibuprofen | ANDA | 2014-12-05 |
| memantine | ANDA | 2024-09-26 |
| memantine and donepezil hydrochlorides extended-release | ANDA | 2020-12-29 |
| memantine hcl | ANDA | 2024-02-29 |
| memantine hydrochloride | ANDA | 2024-09-05 |
| memantine hydrochloride memantine hydrochloride | ANDA | 2021-12-22 |
| namenda | New Drug Application | 2019-11-30 |
| namenda namenda xr | New Drug Application | 2017-12-28 |
| namzaric | New Drug Application | 2024-05-13 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alzheimer disease | EFO_0000249 | D000544 | F03 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Donepezil Hydrochloride / Memantine Hydrochloride, Namzaric, Abbvie | |||
| 8058291 | 2029-12-05 | U-1641 | |
| 8039009 | 2029-03-24 | U-539, U-1641 | |
| 8168209 | 2025-11-22 | DP | |
| 8173708 | 2025-11-22 | U-1641 | |
| 8283379 | 2025-11-22 | U-1641 | |
| 8293794 | 2025-11-22 | DP | |
| 8329752 | 2025-11-22 | DP | |
| 8338485 | 2025-11-22 | DP | |
| 8338486 | 2025-11-22 | U-1641 | |
| 8362085 | 2025-11-22 | U-1641 | |
| 8580858 | 2025-11-22 | U-1641 | |
| 8598233 | 2025-11-22 | DP | |
HCPCS
No data
Clinical
Clinical Trials
252 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 5 | 12 | 15 | 25 | 14 | 70 |
| Dementia | D003704 | EFO_0003862 | F03 | — | 4 | 4 | 7 | 9 | 24 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 2 | 8 | 9 | 4 | 3 | 23 |
| Healthy volunteers/patients | — | — | — | 10 | 1 | — | 2 | — | 13 |
| Autistic disorder | D001321 | HP_0000717 | F84.0 | 1 | 6 | 2 | 1 | 2 | 12 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 4 | 5 | 2 | 1 | 11 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | 1 | 4 | 2 | 1 | 3 | 11 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | 1 | 5 | 3 | 10 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 1 | 2 | 5 | 2 | 10 |
| Sclerosis | D012598 | — | — | — | 7 | 3 | 1 | — | 9 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | 2 | 4 | — | — | 7 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | 1 | 3 | 2 | — | 1 | 6 |
| Compulsive personality disorder | D003193 | — | F60.5 | 1 | 3 | 2 | — | 1 | 6 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | — | 5 | 2 | — | — | 5 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 5 | 2 | — | — | 5 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | 2 | — | 2 | 5 |
| Neuralgia | D009437 | EFO_0009430 | — | — | 3 | 1 | — | — | 4 |
| Cognition disorders | D003072 | — | — | — | 1 | 3 | — | 1 | 4 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 3 | 1 | — | — | 4 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 3 | 2 | — | — | 3 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Developmental disabilities | D002658 | EFO_0003852 | F89 | — | 3 | — | — | 1 | 4 |
| Asperger syndrome | D020817 | EFO_0003757 | F84.5 | — | 3 | — | — | 1 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 2 | — | — | — | 3 |
| Tobacco use disorder | D014029 | — | F17 | 2 | 1 | — | — | — | 3 |
| Dyslexia | D004410 | EFO_0005424 | F81.0 | — | 3 | — | — | — | 3 |
| Fragile x syndrome | D005600 | — | Q99.2 | — | 1 | — | — | 2 | 3 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 2 | — | — | — | 2 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | 1 | — | — | 1 | 2 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | 2 | — | — | — | 2 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | — | — | — | 1 |
Show 23 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central nervous system diseases | D002493 | HP_0002011 | G96.9 | 1 | — | — | — | 1 | 2 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 1 | — | — | — | 1 | 2 |
| Gliosarcoma | D018316 | — | — | 1 | — | — | — | — | 1 |
| Crush injuries | D000071576 | — | T14.8 | 1 | — | — | — | — | 1 |
| Sleep deprivation | D012892 | — | F51.12 | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Subdural hematoma | D006408 | HP_0100309 | — | 1 | — | — | — | — | 1 |
| Hematoma | D006406 | EFO_0010680 | — | 1 | — | — | — | — | 1 |
| Subdural hematoma chronic | D020200 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | — | — | — | 3 | 3 |
| Tauopathies | D024801 | — | — | — | — | — | — | 2 | 2 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | — | — | — | 1 | 1 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | — | — | — | — | 1 | 1 |
| Hyperhomocysteinemia | D020138 | — | — | — | — | — | — | 1 | 1 |
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | — | — | — | — | 1 | 1 |
| Tdp-43 proteinopathies | D057177 | — | — | — | — | — | — | 1 | 1 |
| Iron deficiencies | D000090463 | — | — | — | — | — | — | 1 | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 1 | 1 |
| Deep brain stimulation | D046690 | — | — | — | — | — | — | 1 | 1 |
Show 9 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Memantine |
| INN | memantine |
| Description | Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. It has a role as a dopaminergic agent, an antiparkinson drug, a NMDA receptor antagonist, a neuroprotective agent and an antidepressant. It is a member of adamantanes and a primary aliphatic amine. It is a conjugate base of a memantinium(1+). It derives from a hydride of an adamantane. |
| Classification | Small molecule |
| Drug class | antivirals/antiparkinsonians (adamantane derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC12CC3CC(C)(C1)CC(N)(C3)C2 |
Identifiers
| PDB | — |
| CAS-ID | 19982-08-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL807 |
| ChEBI ID | 64312 |
| PubChem CID | 4054 |
| DrugBank | DB01043 |
| UNII ID | W8O17SJF3T (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GRIN2C
GRIN2C
Organism
Homo sapiens
Gene name
GRIN2C
Gene synonyms
NMDAR2C
NCBI Gene ID
Protein name
glutamate receptor ionotropic, NMDA 2C
Protein synonyms
GluN2C(alt_5'UTR_77nt), GluN2C(alt_5'UTR_87nt), GluN2C(del_e2), GluN2C-b alternative isoform, Glutamate [NMDA] receptor subunit epsilon-3, glutamate receptor, ionotropic, N-methyl D-aspartate 2C, N-methyl D-aspartate receptor subtype 2C, N-methyl-D-aspartate receptor subunit 2C, NMDAR2C, NR2C, putative NMDtranscript(altAcc_e11), putative NMDtranscript(altDon_e4), putative NMDtranscript(del_e4)
Uniprot ID
Mouse ortholog
Grin2c (14813)
glutamate receptor ionotropic, NMDA 2C (Q01098)
Variants
No data
Financial
Revenue by drug
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Namenda – Allergan
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Namenda – Warner Chilcott
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Namzaric – Allergan
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Namzaric – Warner Chilcott
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Estimated US medical usage
Memantine
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Ibuprofen
Adverse Events
Top Adverse Reactions
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13,191 adverse events reported
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