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Drug ReportsMemantine
Namenda, Ebixa(memantine)
Axura, Ebixa, Marixino, Maruxa, Memantine, Namenda, Namzaric, Nemdatine (memantine) is a small molecule pharmaceutical. Memantine was first approved as Ebixa on 2002-05-15. It is used to treat alzheimer disease in the USA. It has been approved in Europe to treat alzheimer disease. It is known to target glutamate receptor ionotropic, NMDA 2C.
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Drug
Target
Variants
Financial
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Events Timeline
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3M
6M
YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
mental disordersD001523
Trade Name
FDA
EMA
Memantine, Namenda (discontinued: Memantine, Namenda)
Combinations
Memantine donepezil, Namzaric
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Memantine hydrochloride
Tradename
Company
Number
Date
Products
NAMENDAAbbVieN-021487 RX2003-10-16
2 products, RLD, RS
Show 2 discontinued
Donepezil hydrochloride
+
Memantine hydrochloride
Tradename
Company
Number
Date
Products
NAMZARICAbbVieN-206439 RX2014-12-23
4 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
generic drugunapproved drug other2019-05-07
ibuprofenANDA2014-12-05
memantineANDA2024-09-26
memantine and donepezil hydrochloridesANDA2025-01-01
memantine and donepezil hydrochlorides extended-releaseANDA2025-02-06
memantine hclANDA2024-02-29
memantine hydrochlorideANDA2025-02-04
memantine hydrochloride memantine hydrochlorideANDA2021-12-22
namendaNew Drug Application2019-11-30
namenda namenda xrNew Drug Application2017-12-28
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
alzheimer diseaseEFO_0000249D000544F03
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Donepezil Hydrochloride / Memantine Hydrochloride, Namzaric, Abbvie
80582912029-12-05U-1641
80390092029-03-24U-539, U-1641
81682092025-11-22DP
81737082025-11-22U-1641
82833792025-11-22U-1641
82937942025-11-22DP
83297522025-11-22DP
83384852025-11-22DP
83384862025-11-22U-1641
83620852025-11-22U-1641
85808582025-11-22U-1641
85982332025-11-22DP
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06D: Anti-dementia drugs
— N06DA: Anticholinesterase anti-dementia drugs
— N06DA52: Donepezil and memantine
— N06DA53: Donepezil, memantine and ginkgo folium
— N06DX: Other anti-dementia drugs in atc
— N06DX01: Memantine
HCPCS
No data
Clinical
Clinical Trials
255 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlaucomaD005901EFO_0000516H40——2——2
Open-angle glaucomaD005902EFO_0004190H40.1——2——2
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F031————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMemantine
INNmemantine
Description
Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. It has a role as a dopaminergic agent, an antiparkinson drug, a NMDA receptor antagonist, a neuroprotective agent and an antidepressant. It is a member of adamantanes and a primary aliphatic amine. It is a conjugate base of a memantinium(1+). It derives from a hydride of an adamantane.
Classification
Small molecule
Drug classantivirals/antiparkinsonians (adamantane derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC12CC3CC(C)(C1)CC(N)(C3)C2
Identifiers
PDB—
CAS-ID19982-08-2
RxCUI—
ChEMBL IDCHEMBL807
ChEBI ID64312
PubChem CID4054
DrugBankDB01043
UNII IDW8O17SJF3T (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GRIN2C
GRIN2C
Organism
Homo sapiens
Gene name
GRIN2C
Gene synonyms
NMDAR2C
NCBI Gene ID
2905
Protein name
glutamate receptor ionotropic, NMDA 2C
Protein synonyms
GluN2C(alt_5'UTR_77nt), GluN2C(alt_5'UTR_87nt), GluN2C(del_e2), GluN2C-b alternative isoform, Glutamate [NMDA] receptor subunit epsilon-3, glutamate receptor, ionotropic, N-methyl D-aspartate 2C, N-methyl D-aspartate receptor subtype 2C, N-methyl-D-aspartate receptor subunit 2C, NMDAR2C, NR2C, putative NMDtranscript(altAcc_e11), putative NMDtranscript(altDon_e4), putative NMDtranscript(del_e4)
Uniprot ID
Q14957
Mouse ortholog
Grin2c (14813)
glutamate receptor ionotropic, NMDA 2C (Q01098)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Namenda – Allergan
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Namenda – Warner Chilcott
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Namzaric – Allergan
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Namzaric – Warner Chilcott
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Tabular view
Estimated US medical usage
Memantine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20,469 documents
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Safety
Black-box Warning
Black-box warning for: Ibuprofen
Adverse Events
Top Adverse Reactions
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13,424 adverse events reported
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