Tradename | Company | Number | Date | Products |
---|---|---|---|---|
EVOMELA | Acrotech Biopharma | N-207155 RX | 2016-03-10 | 1 products, RLD, RS |
IVRA | Apotex | N-217110 RX | 2023-08-18 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
evomela | New Drug Application | 2023-06-13 |
hepzato kit | New Drug Application | 2024-11-22 |
ivra | New Drug Application | 2025-03-23 |
melphalan | ANDA | 2025-03-31 |
melphalan hydrochloride | ANDA | 2025-03-28 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
breast neoplasms | EFO_0003869 | D001943 | C50 |
ovarian neoplasms | EFO_0003893 | D010051 | C56 |
multiple myeloma | — | D009101 | C90.0 |
neuroblastoma | EFO_0000621 | D009447 | — |
rhabdomyosarcoma | — | D012208 | — |
Expiration | Code | ||
---|---|---|---|
MELPHALAN HYDROCHLORIDE, HEPZATO, DELCATH SYSTEMS INC | |||
2030-08-14 | ODE-438 | ||
2026-08-14 | NP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Melphalan Hydrochloride, Melphalan Hydrochloride, Apotex | |||
10537520 | 2036-06-29 | DP | |
Melphalan Hydrochloride, Hepzato, Delcath Systems Inc | |||
9707331 | 2034-09-17 | DP | |
9314561 | 2034-02-07 | DP | |
10195334 | 2033-01-16 | DP | |
11083831 | 2032-12-30 | DP | |
11833286 | 2032-12-30 | DP | |
10098997 | 2032-11-07 | DP | |
10369264 | 2032-11-07 | DP | |
10569004 | 2032-11-07 | U-3680, U-3683 | |
11241522 | 2032-11-07 | DP | |
11633528 | 2032-11-07 | U-3675 | |
Melphalan Hydrochloride, Evomela, Acrotech Biopharma | |||
10040872 | 2034-01-30 | DP | |
9493582 | 2033-02-27 | DP | |
10940128 | 2030-06-14 | DP | U-3086 |
10864183 | 2030-05-28 | DP | |
11020363 | 2030-05-28 | DP | |
8410077 | 2029-03-13 | DP | |
9200088 | 2029-03-13 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Multiple myeloma | D009101 | — | C90.0 | 95 | 230 | 81 | 7 | 37 | 392 |
Plasma cell neoplasms | D054219 | — | — | 84 | 202 | 77 | 7 | 27 | 342 |
Lymphoma | D008223 | — | C85.9 | 64 | 152 | 19 | 2 | 26 | 233 |
Leukemia | D007938 | — | C95 | 56 | 122 | 11 | 1 | 22 | 184 |
Myeloid leukemia acute | D015470 | — | C92.0 | 28 | 62 | 8 | 1 | 11 | 97 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 31 | 61 | 4 | 2 | 9 | 92 |
Myeloid leukemia | D007951 | — | C92 | 26 | 56 | 8 | 1 | 11 | 89 |
Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 8 | 18 | 4 | 1 | 4 | 32 |
B-cell lymphoma | D016393 | — | — | 14 | 15 | 3 | 1 | 4 | 32 |
Mucositis | D052016 | EFO_1001898 | — | 1 | 2 | 1 | 1 | 6 | 11 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myelodysplastic syndromes | D009190 | — | D46 | 34 | 77 | 7 | — | 10 | 112 |
Neoplasms | D009369 | — | C80 | 38 | 58 | 4 | — | 10 | 95 |
Preleukemia | D011289 | — | — | 26 | 56 | 6 | — | 5 | 79 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 19 | 47 | 2 | — | 11 | 72 |
Plasmacytoma | D010954 | — | C90.3 | 15 | 47 | 11 | — | 5 | 69 |
Syndrome | D013577 | — | — | 20 | 43 | 6 | — | 7 | 66 |
Hodgkin disease | D006689 | — | C81 | 19 | 47 | 1 | — | 9 | 65 |
Hematologic neoplasms | D019337 | — | — | 19 | 40 | 1 | — | 4 | 55 |
Neuroblastoma | D009447 | EFO_0000621 | — | 16 | 20 | 13 | — | 4 | 49 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 13 | 35 | 1 | — | 4 | 45 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Recurrence | D012008 | — | — | 19 | 20 | — | — | 8 | 38 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 7 | 28 | — | — | 5 | 36 |
Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 6 | 20 | — | — | 2 | 25 |
Graft vs host disease | D006086 | — | D89.81 | 9 | 20 | — | — | 1 | 25 |
Primary myelofibrosis | D055728 | — | D47.4 | 7 | 12 | — | — | 2 | 21 |
Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 5 | 14 | — | — | 1 | 18 |
Carcinoma | D002277 | — | C80.0 | 5 | 7 | — | — | 2 | 14 |
Immunologic deficiency syndromes | D007153 | — | D84.9 | 6 | 9 | — | — | 2 | 14 |
Germ cell and embryonal neoplasms | D009373 | — | — | 7 | 6 | — | — | 1 | 12 |
Plasma cell leukemia | D007952 | — | C90.1 | 4 | 8 | — | — | 1 | 11 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Paraproteinemias | D010265 | — | D47.2 | 1 | — | — | — | 1 | 2 |
Ependymoma | D004806 | — | — | 2 | — | — | — | — | 2 |
Choroid plexus neoplasms | D016545 | EFO_0007206 | — | 2 | — | — | — | — | 2 |
Phenylketonurias | D010661 | — | E70.0 | 1 | — | — | — | 1 | 2 |
Fallopian tube neoplasms | D005185 | — | — | 2 | — | — | — | — | 2 |
Leukemia myeloid chronic atypical bcr-abl negative | D054438 | — | C92.2 | 1 | — | — | — | 1 | 2 |
Lysosomal storage diseases | D016464 | — | — | 1 | — | — | — | 1 | 2 |
Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | — | 1 |
Thyroid neoplasms | D013964 | EFO_0003841 | — | 1 | — | — | — | — | 1 |
Papillary thyroid cancer | D000077273 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Skin neoplasms | D012878 | EFO_0004198 | C44 | — | — | — | — | 2 | 2 |
Intraocular lymphoma | D064090 | — | — | — | — | — | — | 2 | 2 |
Abnormal karyotype | D059786 | — | — | — | — | — | — | 1 | 1 |
Basal cell carcinoma | D002280 | — | — | — | — | — | — | 1 | 1 |
Squamous cell carcinoma | D002294 | — | — | — | — | — | — | 1 | 1 |
Eccrine porocarcinoma | D057090 | — | — | — | — | — | — | 1 | 1 |
Neutrophilic leukemia chronic | D015467 | — | D47.1 | — | — | — | — | 1 | 1 |
Hypereosinophilic syndrome | D017681 | EFO_1001467 | D72.11 | — | — | — | — | 1 | 1 |
Eosinophilic leukemia acute | D015472 | — | — | — | — | — | — | 1 | 1 |
Cryotherapy | D017679 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Melphalan |
INN | melphalan |
Description | Melphalan is a phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring. It has a role as an antineoplastic agent, a carcinogenic agent, an alkylating agent, an immunosuppressive agent and a drug allergen. It is an organochlorine compound, a nitrogen mustard, a L-phenylalanine derivative and a non-proteinogenic L-alpha-amino acid. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O |
PDB | — |
CAS-ID | 148-82-3 |
RxCUI | — |
ChEMBL ID | CHEMBL852 |
ChEBI ID | 28876 |
PubChem CID | 460612 |
DrugBank | DB01042 |
UNII ID | Q41OR9510P (ChemIDplus, GSRS) |