Tradename | Company | Number | Date | Products |
---|---|---|---|---|
EVOMELA | Acrotech Biopharma | N-207155 RX | 2016-03-10 | 1 products, RLD, RS |
MELPHALAN HYDROCHLORIDE | Apotex | N-217110 RX | 2023-08-18 | 1 products, RLD, RS |
HEPZATO | DELCATH SYSTEMS INC | N-201848 RX | 2023-08-14 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
hepzato kit | New Drug Application | 2023-12-05 |
melphalan hydrochloride | ANDA | 2020-09-16 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
breast neoplasms | EFO_0003869 | D001943 | C50 |
multiple myeloma | — | D009101 | C90.0 |
neuroblastoma | EFO_0000621 | D009447 | — |
ovarian neoplasms | EFO_0003893 | D010051 | C56 |
rhabdomyosarcoma | — | D012208 | — |
Expiration | Code | ||
---|---|---|---|
MELPHALAN HYDROCHLORIDE, HEPZATO, DELCATH SYSTEMS INC | |||
2030-08-14 | ODE-438 | ||
2026-08-14 | NP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Melphalan Hydrochloride, Melphalan Hydrochloride, Apotex | |||
10537520 | 2036-06-29 | DP | |
Melphalan Hydrochloride, Hepzato, Delcath Systems Inc | |||
9707331 | 2034-09-17 | DP | |
9314561 | 2034-02-07 | DP | |
10195334 | 2033-01-16 | DP | |
11083831 | 2032-12-30 | DP | |
11833286 | 2032-12-30 | DP | |
10098997 | 2032-11-07 | DP | |
10369264 | 2032-11-07 | DP | |
10569004 | 2032-11-07 | U-3680, U-3683 | |
11241522 | 2032-11-07 | DP | |
11633528 | 2032-11-07 | U-3675 | |
Melphalan Hydrochloride, Evomela, Acrotech Biopharma | |||
10040872 | 2034-01-30 | DP | |
9493582 | 2033-02-27 | DP | |
10940128 | 2030-06-14 | DP | U-3086 |
10864183 | 2030-05-28 | DP | |
11020363 | 2030-05-28 | DP | |
8410077 | 2029-03-13 | DP | |
9200088 | 2029-03-13 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Multiple myeloma | D009101 | — | C90.0 | 67 | 171 | 65 | 6 | 28 | 294 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 25 | 51 | 1 | 2 | 8 | 73 |
Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 6 | 14 | 4 | 1 | 3 | 26 |
Burkitt lymphoma | D002051 | — | C83.7 | 2 | 5 | — | 1 | 3 | 10 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Lymphoma | D008223 | — | C85.9 | 33 | 81 | 12 | — | 15 | 127 |
Myelodysplastic syndromes | D009190 | — | D46 | 31 | 67 | 6 | — | 9 | 98 |
Myeloid leukemia acute | D015470 | — | C92.0 | 23 | 53 | 5 | — | 10 | 82 |
Leukemia | D007938 | — | C95 | 26 | 51 | 5 | — | 8 | 75 |
Plasma cell neoplasms | D054219 | — | — | 15 | 45 | 11 | — | 4 | 66 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 14 | 42 | 2 | — | 9 | 62 |
Neuroblastoma | D009447 | EFO_0000621 | — | 16 | 20 | 13 | — | 4 | 49 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 9 | 29 | 1 | — | 4 | 36 |
Neoplasms | D009369 | — | C80 | 14 | 16 | 3 | — | 4 | 31 |
Sarcoma | D012509 | — | — | 8 | 13 | 1 | — | 4 | 24 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hodgkin disease | D006689 | — | C81 | 17 | 40 | — | — | 9 | 56 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 6 | 24 | — | — | 5 | 32 |
Hematologic neoplasms | D019337 | — | — | 9 | 17 | — | — | 2 | 24 |
Graft vs host disease | D006086 | — | D89.81 | 7 | 16 | — | — | 1 | 20 |
Primary myelofibrosis | D055728 | — | D47.4 | 5 | 9 | — | — | 2 | 16 |
Aplastic anemia | D000741 | HP_0001915 | D61.9 | 4 | 8 | — | — | 5 | 15 |
Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 2 | 11 | — | — | 1 | 12 |
Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 3 | 9 | — | — | 1 | 12 |
Plasma cell leukemia | D007952 | — | C90.1 | 4 | 7 | — | — | 1 | 10 |
Paroxysmal hemoglobinuria | D006457 | Orphanet_447 | D59.12 | — | 6 | — | — | 3 | 9 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Wilms tumor | D009396 | EFO_0000212 | — | 2 | — | — | — | 1 | 3 |
Ependymoma | D004806 | — | — | 2 | — | — | — | — | 2 |
Choroid plexus neoplasms | D016545 | EFO_0007206 | — | 2 | — | — | — | — | 2 |
Phenylketonurias | D010661 | — | E70.0 | 1 | — | — | — | 1 | 2 |
Fallopian tube neoplasms | D005185 | — | — | 2 | — | — | — | — | 2 |
Neuroectodermal tumors | D017599 | — | — | 1 | — | — | — | 1 | 2 |
Lysosomal storage diseases | D016464 | — | — | 1 | — | — | — | 1 | 2 |
Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | 1 | 2 |
Papillary thyroid cancer | D000077273 | — | — | 1 | — | — | — | — | 1 |
Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Intraocular lymphoma | D064090 | — | — | — | — | — | — | 2 | 2 |
Paraproteinemias | D010265 | — | D47.2 | — | — | — | — | 1 | 1 |
Basal cell carcinoma | D002280 | — | — | — | — | — | — | 1 | 1 |
Skin neoplasms | D012878 | EFO_0004198 | C44 | — | — | — | — | 1 | 1 |
Squamous cell carcinoma | D002294 | — | — | — | — | — | — | 1 | 1 |
Eccrine porocarcinoma | D057090 | — | — | — | — | — | — | 1 | 1 |
Thymoma | D013945 | — | — | — | — | — | — | 1 | 1 |
Leukemia myeloid chronic atypical bcr-abl negative | D054438 | — | C92.2 | — | — | — | — | 1 | 1 |
Neutrophilic leukemia chronic | D015467 | — | D47.1 | — | — | — | — | 1 | 1 |
Stomatitis | D013280 | EFO_1001904 | K12.1 | — | — | — | — | 1 | 1 |
Drug common name | Melphalan |
INN | melphalan |
Description | Melphalan is a phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring. It has a role as an antineoplastic agent, a carcinogenic agent, an alkylating agent, an immunosuppressive agent and a drug allergen. It is an organochlorine compound, a nitrogen mustard, a L-phenylalanine derivative and a non-proteinogenic L-alpha-amino acid. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O |
PDB | — |
CAS-ID | 148-82-3 |
RxCUI | — |
ChEMBL ID | CHEMBL852 |
ChEBI ID | 28876 |
PubChem CID | 460612 |
DrugBank | DB01042 |
UNII ID | Q41OR9510P (ChemIDplus, GSRS) |