MECLOFENAMIC ACID
Meclofenamate (meclofenamic acid) is a small molecule pharmaceutical. Meclofenamic acid was first approved as Meclomen on 1982-01-01. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Meclofenamate (discontinued: Meclofenamate, Meclomen)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| meclofenamate sodium | ANDA | 2024-07-15 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AG: Fenamates, antiinflammatory and antirheumatic drugs
— M01AG04: Meclofenamic acid
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA18: Meclofenamic acid
HCPCS
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | — | — | — | 1 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | — | — | — | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | — | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | — | — | — | 1 | 1 |
| Second primary neoplasms | D016609 | — | — | — | — | — | — | 1 | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MECLOFENAMIC ACID |
| INN | meclofenamic acid |
| Description | Meclofenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis. It has a role as a non-steroidal anti-inflammatory drug, an antirheumatic drug, an antineoplastic agent, an anticonvulsant, an analgesic, an antipyretic, an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is an aminobenzoic acid, a secondary amino compound and an organochlorine compound. It is a conjugate acid of a meclofenamic acid(1-). |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (anthranilic acid derivatives) and their salts or esters |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl |
Identifiers
| PDB | — |
| CAS-ID | 644-62-2 |
| RxCUI | 588003 |
| ChEMBL ID | CHEMBL509 |
| ChEBI ID | 6710 |
| PubChem CID | 4037 |
| DrugBank | DB00939 |
| UNII ID | 48I5LU4ZWD (ChemIDplus, GSRS) |
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
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Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Meclofenamic acid
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Meclofenamate
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,100 documents
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Safety
Black-box Warning
Black-box warning for: Meclofenamate sodium
Adverse Events
Top Adverse Reactions
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20 adverse events reported
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