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Drug ReportsMechlorethamine
Mustargen, Ledaga(mechlorethamine)
Ledaga, Valchlor (mechlorethamine) is a small molecule pharmaceutical. Mechlorethamine was first approved as Mustargen on 1982-01-01. It is used to treat hodgkin disease, malignant pleural effusion, mycosis fungoides, and neoplasm metastasis in the USA. It has been approved in Europe to treat mycosis fungoides.
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Events Timeline
5D
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FDA approval date
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Study first post date
Last update post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
respiratory tract diseasesD012140
hemic and lymphatic diseasesD006425
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Valchlor (discontinued: Mustargen)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mechlorethamine hydrochloride
Tradename
Company
Number
Date
Products
VALCHLORHelsinn Birex PharmaceuticalsN-202317 RX2013-08-23
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
valchlorNew Drug Application2024-11-20
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
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FDA Information
Mechlorethamine Hydrochloride, Valchlor, Helsinn
78720502029-07-08U-1427
78385642026-03-07DP
84503752026-03-07DP
85018182026-03-07DP
85018192026-03-07U-1427
93821912026-03-07DP
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01A: Alkylating agents
L01AA: Nitrogen mustard analogues
L01AA05: Chlormethine
HCPCS
Code
Description
J9230
Injection, mechlorethamine hydrochloride, (nitrogen mustard), 10 mg
Clinical
Clinical Trials
4835 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.937779119514541249
LeukemiaD007938C952855041361843859
Breast neoplasmsD001943EFO_0003869C501103601761344637
Multiple myelomaD009101C90.020036065824567
Non-hodgkin lymphomaD008228C85.918331568321499
Plasma cell neoplasmsD05421915527855718442
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0143241671720425
Lymphoid leukemiaD007945C91132227771716415
B-cell lymphomaD01639316220933312344
Large b-cell lymphoma diffuseD016403C83.312020448311329
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C802301862520384
Myeloid leukemia acuteD015470C92.0971543112258
Myeloid leukemiaD007951C92761372611218
RecurrenceD012008799096153
MelanomaD008545878266150
Hematologic neoplasmsD019337598678136
Ovarian neoplasmsD010051EFO_0003893C566870102121
Myeloproliferative disordersD009196D47.13482411120
NeuroblastomaD009447EFO_00006214846227115
CarcinomaD002277C80.0665964113
Show 224 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver neoplasmsD008113EFO_1001513C22.02617237
Mycosis fungoidesD009182C84.01219937
T-cell lymphoma cutaneousD016410C84.A1319836
MycosesD009181B35-B491018530
Skin neoplasmsD012878EFO_0004198C441119328
Hepatocellular carcinomaD006528C22.01612122
Myeloid leukemia accelerated phaseD015465517121
Adult t-cell leukemia-lymphomaD015459C91.5913221
MesotheliomaD008654C451712121
Prolymphocytic leukemiaD015463515120
Show 267 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PinealomaD01087155
Muscular diseasesD009135EFO_0002970G72.944
Adrenocortical carcinomaD01826833
Papillary thyroid cancerD00007727322
Barrett esophagusD001471EFO_0000280K22.722
Neuroepithelial neoplasmsD01830222
Optic nerve gliomaD02033922
Lysosomal storage diseasesD016464112
Ductal carcinomaD04458422
Lymphomatoid papulosisD017731C86.6112
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMechlorethamine
INNchlormethine
Description
Mechlorethamine is a nitrogen mustard and an organochlorine compound. It has a role as an alkylating agent.
Classification
Small molecule
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(CCCl)CCCl
Identifiers
PDB
CAS-ID51-75-2
RxCUI
ChEMBL IDCHEMBL427
ChEBI ID28925
PubChem CID4033
DrugBankDB00888
UNII ID50D9XSG0VR (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,426 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,807 adverse events reported
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