Mechlorethamine
Ledaga, Valchlor (mechlorethamine) is a small molecule pharmaceutical. Mechlorethamine was first approved as Mustargen on 1982-01-01. It is used to treat hodgkin disease, malignant pleural effusion, mycosis fungoides, and neoplasm metastasis in the USA. It has been approved in Europe to treat mycosis fungoides.
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Commercial
Trade Name
FDA
EMA
Valchlor (discontinued: Mustargen)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mechlorethamine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VALCHLOR | Helsinn Birex Pharmaceuticals | N-202317 RX | 2013-08-23 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| valchlor | New Drug Application | 2024-05-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hodgkin disease | — | D006689 | C81 |
| mycosis fungoides | — | D009182 | C84.0 |
| neoplasm metastasis | EFO_0009708 | D009362 | — |
| malignant pleural effusion | — | D016066 | J91.0 |
Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| J9230 | Injection, mechlorethamine hydrochloride, (nitrogen mustard), 10 mg |
Clinical
Clinical Trials
312 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 28 | 45 | 10 | 2 | 6 | 80 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 15 | 25 | 2 | 1 | 4 | 38 |
| B-cell lymphoma | D016393 | — | — | 13 | 11 | 2 | 1 | 4 | 26 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 11 | 10 | 2 | 1 | 4 | 25 |
| T-cell lymphoma | D016399 | — | — | 4 | 7 | — | 1 | 4 | 14 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 5 | 8 | — | 1 | — | 13 |
| T-cell lymphoma peripheral | D016411 | — | — | 1 | 3 | — | 1 | 4 | 9 |
| Burkitt lymphoma | D002051 | — | C83.7 | 2 | 2 | — | 1 | 3 | 7 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | 1 | 3 | — | 1 | 1 | 6 |
| Bronchiolitis | D001988 | HP_0011950 | — | — | 1 | 4 | 1 | — | 5 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 18 | 32 | 4 | — | 2 | 47 |
| Leukemia | D007938 | — | C95 | 15 | 24 | 5 | — | 4 | 44 |
| Plasma cell neoplasms | D054219 | — | — | 17 | 27 | 4 | — | 1 | 40 |
| Recurrence | D012008 | — | — | 20 | 22 | 1 | — | 5 | 38 |
| Hodgkin disease | D006689 | — | C81 | 11 | 23 | 3 | — | 3 | 34 |
| Sarcoma | D012509 | — | — | 7 | 12 | 10 | — | 6 | 32 |
| Neoplasms | D009369 | — | C80 | 13 | 17 | 2 | — | 2 | 31 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 12 | 13 | 4 | — | 3 | 30 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 12 | 12 | 2 | — | 2 | 26 |
| Myeloid leukemia | D007951 | — | C92 | 11 | 12 | 1 | — | 2 | 24 |
Show 63 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 2 | 12 | — | — | 1 | 15 |
| Mycoses | D009181 | — | B35-B49 | 1 | 8 | — | — | 6 | 15 |
| Mycosis fungoides | D009182 | — | C84.0 | 1 | 8 | — | — | 6 | 15 |
| Mantle-cell lymphoma | D020522 | — | — | 7 | 8 | — | — | 3 | 14 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 4 | 10 | — | — | 1 | 13 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 6 | 6 | — | — | 1 | 13 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 5 | 7 | — | — | 3 | 13 |
| Follicular lymphoma | D008224 | — | C82 | 4 | 7 | — | — | 4 | 12 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 2 | 8 | — | — | 1 | 11 |
| Primary myelofibrosis | D055728 | — | D47.4 | 4 | 6 | — | — | 1 | 11 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rhabdoid tumor | D018335 | — | — | 3 | — | — | — | — | 3 |
| Ependymoma | D004806 | — | — | 2 | — | — | — | — | 2 |
| Barrett esophagus | D001471 | EFO_0000280 | K22.7 | 2 | — | — | — | — | 2 |
| Triple negative breast neoplasms | D064726 | — | — | 2 | — | — | — | — | 2 |
| Choroid plexus neoplasms | D016545 | EFO_0007206 | — | 1 | — | — | — | — | 1 |
| Phenylketonurias | D010661 | — | E70.0 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 1 | — | — | — | — | 1 |
| Neuroendocrine carcinoma | D018278 | — | — | 1 | — | — | — | — | 1 |
| Papillary thyroid cancer | D000077273 | — | — | 1 | — | — | — | — | 1 |
Show 28 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 4 | 4 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | — | 3 | 3 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 2 | 2 |
| Dysmenorrhea | D004412 | HP_0100607 | N94.6 | — | — | — | — | 2 | 2 |
| Intraocular lymphoma | D064090 | — | — | — | — | — | — | 2 | 2 |
| Blood circulation | D001775 | — | — | — | — | — | — | 2 | 2 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 1 | 1 |
| Glucose metabolism disorders | D044882 | — | — | — | — | — | — | 1 | 1 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
Show 44 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mechlorethamine |
| INN | chlormethine |
| Description | Mechlorethamine is a nitrogen mustard and an organochlorine compound. It has a role as an alkylating agent. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(CCCl)CCCl |
Identifiers
| PDB | — |
| CAS-ID | 51-75-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL427 |
| ChEBI ID | 28925 |
| PubChem CID | 4033 |
| DrugBank | DB00888 |
| UNII ID | 50D9XSG0VR (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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2,699 adverse events reported
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