Mustargen, Ledaga(mechlorethamine)
Ledaga, Valchlor (mechlorethamine) is a small molecule pharmaceutical. Mechlorethamine was first approved as Mustargen on 1982-01-01. It is used to treat hodgkin disease, malignant pleural effusion, mycosis fungoides, and neoplasm metastasis in the USA. It has been approved in Europe to treat mycosis fungoides.
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Commercial
Trade Name
FDA
EMA
Valchlor (discontinued: Mustargen)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mechlorethamine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VALCHLOR | Helsinn Birex Pharmaceuticals | N-202317 RX | 2013-08-23 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| valchlor | New Drug Application | 2024-11-20 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| J9230 | Injection, mechlorethamine hydrochloride, (nitrogen mustard), 10 mg |
Clinical
Clinical Trials
4883 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 348 | 744 | 176 | 14 | 54 | 1166 |
| Leukemia | D007938 | — | C95 | 262 | 480 | 128 | 18 | 43 | 814 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 108 | 354 | 176 | 13 | 44 | 631 |
| Multiple myeloma | D009101 | — | C90.0 | 199 | 361 | 65 | 8 | 25 | 569 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 181 | 310 | 67 | 3 | 21 | 491 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 143 | 246 | 67 | 17 | 20 | 429 |
| Plasma cell neoplasms | D054219 | — | — | 145 | 270 | 53 | 6 | 18 | 421 |
| Lymphoid leukemia | D007945 | — | C91 | 121 | 210 | 67 | 17 | 15 | 380 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 122 | 202 | 48 | 3 | 11 | 327 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 107 | 182 | 60 | 4 | 12 | 323 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 222 | 178 | 25 | — | 21 | 370 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 98 | 155 | 31 | — | 12 | 260 |
| Myeloid leukemia | D007951 | — | C92 | 62 | 125 | 26 | — | 10 | 197 |
| Recurrence | D012008 | — | — | 80 | 91 | 12 | — | 6 | 157 |
| Melanoma | D008545 | — | — | 87 | 82 | 6 | — | 6 | 150 |
| Hematologic neoplasms | D019337 | — | — | 61 | 85 | 7 | — | 8 | 136 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 34 | 84 | 4 | — | 11 | 122 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 68 | 70 | 10 | — | 2 | 121 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 49 | 46 | 22 | — | 7 | 116 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 24 | 86 | 8 | — | 6 | 111 |
Show 231 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 26 | 17 | — | — | 2 | 37 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 13 | 20 | — | — | 8 | 37 |
| Mycosis fungoides | D009182 | — | C84.0 | 12 | 19 | — | — | 9 | 37 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 9 | 21 | — | — | 3 | 28 |
| Mycoses | D009181 | — | B35-B49 | 8 | 18 | — | — | 5 | 28 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 18 | 12 | — | — | 1 | 24 |
| Myeloid leukemia accelerated phase | D015465 | — | — | 5 | 17 | — | — | 1 | 21 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 9 | 13 | — | — | 2 | 21 |
| Mesothelioma | D008654 | — | C45 | 17 | 11 | — | — | 1 | 20 |
| Sezary syndrome | D012751 | — | C84.1 | 8 | 11 | — | — | 3 | 20 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pinealoma | D010871 | — | — | 5 | — | — | — | — | 5 |
| Adrenocortical carcinoma | D018268 | — | — | 3 | — | — | — | — | 3 |
| Papillary thyroid cancer | D000077273 | — | — | 2 | — | — | — | — | 2 |
| Barrett esophagus | D001471 | EFO_0000280 | K22.7 | 2 | — | — | — | — | 2 |
| Neuroepithelial neoplasms | D018302 | — | — | 2 | — | — | — | — | 2 |
| Optic nerve glioma | D020339 | — | — | 2 | — | — | — | — | 2 |
| Lysosomal storage diseases | D016464 | — | — | 1 | — | — | — | 1 | 2 |
| Ductal carcinoma | D044584 | — | — | 2 | — | — | — | — | 2 |
| Muscular diseases | D009135 | EFO_0002970 | G72.9 | 2 | — | — | — | — | 2 |
| Lymphomatoid papulosis | D017731 | — | C86.6 | 1 | — | — | — | 1 | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 4 | 4 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 4 | 4 |
| Hemoglobin sc disease | D006450 | EFO_1001797 | D57.2 | — | — | — | — | 2 | 2 |
| Dysmenorrhea | D004412 | — | N94.6 | — | — | — | — | 2 | 2 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | — | — | — | 2 | 2 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 2 | 2 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 2 | 2 |
| Iga vasculitis | D011695 | EFO_1000965 | D69.0 | — | — | — | — | 2 | 2 |
| Blood circulation | D001775 | — | — | — | — | — | — | 2 | 2 |
| Chronic pain | D059350 | — | — | — | — | — | — | 2 | 2 |
Show 76 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mechlorethamine |
| INN | chlormethine |
| Description | Mechlorethamine is a nitrogen mustard and an organochlorine compound. It has a role as an alkylating agent. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(CCCl)CCCl |
Identifiers
| PDB | — |
| CAS-ID | 51-75-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL427 |
| ChEBI ID | 28925 |
| PubChem CID | 4033 |
| DrugBank | DB00888 |
| UNII ID | 50D9XSG0VR (ChemIDplus, GSRS) |
Target
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Safety
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Adverse Events
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2,827 adverse events reported
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